Collision Cross Section Measurements in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS) Based on the Flipping-Filtering Method [0.03%]
基于翻转过滤法的傅立叶变换离子回旋共振质谱碰撞截面测量
Dayu Li,Zhiwei Wang,Yanying Fan et al.
Dayu Li et al.
The ion collision cross section (CCS) is closely related to the structural and physical conformation of compounds, making it an ideal parameter for constructing databases. In recent years, Fourier transform ion cyclotron resonance mass spec...
Prediction of Fragmentation Pathway of Natural Products, Antibiotics, and Pesticides by ChemFrag [0.03%]
利用ChemFrag预测天然产物、抗生素和农药的裂解途径
Jördis-Ann Schüler,Annemarie E Kramell,Antonia Schmidt et al.
Jördis-Ann Schüler et al.
Because the manual interpretation of ESI-MSn fragmentation spectra is time-consuming and usually requires expert knowledge, automated annotation is often sought. The fragmentation software ChemFrag enables the annotation of MSn spectra by c...
Identification of Mitapivat's In Vivo Metabolites in the Rat Model by Quadrupole-Time-of-Flight (Q-TOF) Mass Spectrometry [0.03%]
质谱法识别米塔皮瓦特的体内代谢物
Saurabh Pandurang Bodake,Anjali Mukesh,Akshay Bandgar et al.
Saurabh Pandurang Bodake et al.
Mitapivat is a novel, first-in-class, allosteric activator of pyruvate kinase enzyme. It has been approved by the US FDA in February 2022 for disease modifying treatment of haemolytic anaemia in adults. In the current study, the in vivo met...
Development of High-Throughput Quantitative Imaging Mass Spectrometry for Analysis of Drug Distribution in Tissues [0.03%]
高通量定量成像质谱技术在药物组织分布分析中的发展
Yukari Tanaka
Yukari Tanaka
Matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS) is applied in drug discovery and development. A high-throughput quantitative MALDI-IMS methodology was developed to confirm whether epertinib is superior to l...
Haorong Li,Wan Nur Atiqah Binti Mazli,Ling Hao
Haorong Li
Proximity labeling (PL) proteomics has emerged as a powerful tool to capture both stable and transient protein interactions and subcellular networks. Despite the wide biological applications, PL still faces technical challenges in robustnes...
Determination of the Metabolic Mechanism of the Principal Components From Moringa oleifera (Lam) Seed by MALDI-IMS [0.03%]
MALDI-IMS测定摩拉瓜籽主要成分的代谢机制
Tao Wang,Jinglin Wang,Saifei Yang et al.
Tao Wang et al.
In this study, the components of Moringa oleifera (Lam) seed were extracted using an ultrasonic-assisted extraction technique with 70% methanol solution as the solvent. The antioxidant properties of the extract were evaluated through its sc...
Analysis of Amine Drugs Dissolved in Methanol by High-Resolution Accurate Mass Gas Chromatography Mass Spectrometry, GC-Orbitrap [0.03%]
甲醇中胺类药物的高分辨准确质量气相色谱轨道质谱分析，GC-Orbitrap
Chee-Leong Kee,Xiaowei Ge,Min-Yong Low et al.
Chee-Leong Kee et al.
The fragmentation pathways for amines dissolved in methanol (CH3OH) or deuterated methanol (CD3OD) have been investigated by high-resolution accurate mass gas chromatography mass spectrometry (HRAM-GCMS) or GC-Orbitrap. Primary and secondar...
Development and Validation of a Rapid Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantitation of Vitamin K Metabolites in Different Matrices [0.03%]
用于不同基质中维生素K代谢物定量的快速液相色谱-串联质谱方法的研发与验证
Danchen Wang,Yichen Ma,Honglei Li et al.
Danchen Wang et al.
Adequate vitamin K is crucial for optimal health. Although vitamin K detection methods have been established using liquid chromatography-tandem mass spectrometry (LC-MS/MS), some limitations remain. Therefore, we aimed to establish a stable...
Precursor Resolution via Ion Z-State Manipulation: A Tandem Mass Spectrometry Approach for the Analysis of Mixtures of Multiply-Charged Ions [0.03%]
通过离子Z态操控实现前体离子的分辨：一种用于分析多重荷电离子混合物的串联质谱技术
Nicolas J Pizzala,Hsi-Chun Chao,Boukar K S Faye et al.
Nicolas J Pizzala et al.
Electrospray ionization (ESI) is often the ionization method of choice, particularly for high-mass polar molecules and complexes. However, when analyzing mixtures of analytes, charge state ambiguities and overlap in mass-to-charge (m/z) can...
Fast Nonlinear Damping Identification Method to Determine Size, Mass, and Charge of Lycopodium clavatum Spores in a Paul Trap [0.03%]
用于确定Paul阱中Lycopodium clavatum孢子的尺寸、质量和电荷的快速非线性阻尼识别方法
Shcherbinin D P,Rybin V V,Semynin M S et al.
Shcherbinin D P et al.
In the present work, we have first applied the fast nonlinear damping identification (NDI) method to nondestructively and simultaneously determine the values of mass, size, and charge of biological micro-objects trapped in a quadrupole Paul...