Evaluation of a Targeted LC-MS/MS Assay for Clinical Quantification of Urinary Organic Acids [0.03%]
一种临床定量测定尿液有机酸的目标LC-MS/MS分析方法的评估研究
Earnest J P Daniel,Emily Garnett,Deepthi Rajapakshe et al.
Earnest J P Daniel et al.
Gas chromatography-mass spectrometry (GC-MS) is the reference method for urine organic acid analysis but requires complex sample preparation and derivatization, limiting routine clinical use. We developed and validated a targeted Liquid chr...
A Platform for High-Throughput Chemical Analysis of Foods: Characterization of Extra Virgin Olive by Direct Mass Spectrometry and Machine Learning [0.03%]
一种用于食品高通量化学分析的平台：通过直接质谱和机器学习表征初榨橄榄油
Nandhini Sokkalingam,Frances Chu,Joan Zou et al.
Nandhini Sokkalingam et al.
Poor diet is now the leading cause of early death globally. In part, this is because our complex food supply chains are increasingly at risk of overprocessing, contamination, low nutrient content, and economically motivated fraud. Chemical ...
Interactive Software for Interpreting and Curating High-Resolution Electron Ionization Mass Spectra [0.03%]
用于解释和整理高分辨率电子电离质谱的交互式软件
Dmitriy D Matyushin,Anastasia Yu Sholokhova
Dmitriy D Matyushin
Gas chromatography coupled with electron ionization and high-resolution mass spectrometry (GC-EI-HRMS) has been increasingly used in analytical chemistry in recent years. Databases (libraries) of such mass spectra are emerging, and various ...
Mass Spectrometric Characterization of Native Insulin Hexamers and Non-Native Heptamers: Formation and Stability Across Insulin Analogs [0.03%]
原胰岛素六聚体和非天然七聚体的质谱表征：不同胰岛素类似物中的形成与稳定性研究
Emmanuel Dare,Colton G Dixon,Kenneth W Lee
Emmanuel Dare
Insulin aggregation and oligomerization present significant challenges in both therapeutic formulation and fundamental studies of amyloid formation, particularly due to the transient and heterogeneous nature of early-stage oligomers. Here, ...
Determination of Mathieu Stability Plot for Planar Trap With Circular Trapping Region [0.03%]
平面圆阱中的Mathieu稳定性图的确定方法研究
Appala Naidu Kotana,Atanu K Mohanty
Appala Naidu Kotana
Planar toroidal ion traps with circular trapping regions are investigated using a toroidal multipole representation of the electrostatic potential. The multipole expansion coefficients are calculated and employed to model the electric poten...
Evaluating Stabilizers Effects on Aroma Release Dynamics in Ice Cream: A PTR-ToF-MS Analysis [0.03%]
稳定剂对冰淇淋香气释放动力学影响的评估：一项PTR-ToF-MS分析研究
Camila Cossettin Teixeira,Michele Pedrotti,Lorenzo Gennari et al.
Camila Cossettin Teixeira et al.
Capturing the dynamic volatilome of frozen matrices during phase transitions remains an analytical challenge, typically requiring invasive sampling. This study employs proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) a...
Analytical Method Development and Validation for Clofazimine in Human Plasma and Application of LC-MS/MS Based Methods for Clofazimine and Bedaquiline in Indian MDR-TB Patients Stratified by HIV Coinfection [0.03%]
用于人血浆中氯法齐明的分析方法开发和验证及基于LC-MS / MS的方法对印度MDR-TB患者中的氯法齐明和贝达喹啉进行分类(HIV合并感染)
Rohan V Lokhande,Prerna R Arora,Ganesh R Bhagure et al.
Rohan V Lokhande et al.
Multidrug-resistant tuberculosis (MDR-TB) remains a major cause of morbidity and mortality worldwide, with people living with HIV experiencing persistently poor treatment outcomes. Clofazimine and bedaquiline are cornerstone drugs in contem...
The ELVIS Probe: Combining Laser Pointer Desorption, Venturi-Assisted Plume Transport, and Electrospray Ionization in a Simple Handheld Tool for Remote Ambient Mass Spectrometry [0.03%]
结合激光指针解吸、文丘里辅助等离子传输和电喷雾离子化的远程质谱分析简易手持工具——ELVIS探针
Andrea Ferreira Machado,Marcos Fernando Franco,Jorge Jardim Zacca et al.
Andrea Ferreira Machado et al.
Here we introduce the Electrospray Laser Venturi Ionization Sampling (ELVIS) probe, a handheld ambient sampling device that combines desorption performed by a simple laser pointer with Venturi-assisted plume transport for remote mass spectr...
Monitoring the Effect of Tributyltin Salicylate and Propionate, Retinoid X Receptor Ligands, on Heat Shock Protein Expression in MDA-MB-231 Cells by MALDI MS/MS [0.03%]
采用基质辅助激光解析电离串联质谱技术监测MDA-MB-231细胞中端粒酶表达的变化
Dana Strouhalova,Dana Macejova,Julius Brtko et al.
Dana Strouhalova et al.
Organotin (IV) compounds are known to induce apoptosis via the intrinsic mitochondrial pathway, which is a key mechanism of effective anticancer therapy. Their ability to selectively promote apoptotic cell death highlights their potential a...
Application of 2D-Chromatography System for the Determination of Cosmetic Peptides in Skin Homogenates [0.03%]
二维色谱法在皮肤匀浆中化妆品肽类测定中的应用研究
Fosca Errante,Marco Pallecchi,Marta Menicatti et al.
Fosca Errante et al.
Peptides are increasingly employed as active ingredients in both therapeutic and cosmeceutical applications due to their high biological specificity, favorable safety profiles, and expanding market relevance. In topical formulations, peptid...