Comprehensive Strategy Analysis of Chemical Constituents of Xiaoliu Powder Based on GC-MS and UPLC-Q-Exactive Orbitrap MS [0.03%]
基于GC-MS和UPLC-Q-Exactive Orbitrap MS的消瘤散化学成分综合策略分析
Jinyuan Bai,Yatong Wang,Na Zhang et al.
Jinyuan Bai et al.
Few studies on Xiaoliu Powder (XLP) have been reported; it is necessary to clarify the material basis of XLP to lay a foundation for further clarifying its mechanism of action and supporting rational drug use. This study aims to comprehensi...
Spatial Mapping of Gangliosides and Proteins in Amyloid Beta Plaques at Cellular Resolution Using Mass Spectrometry Imaging and MALDI-IHC [0.03%]
基于质谱成像和基质辅助激光解析电离免疫组织化学的细胞分辨率级淀粉样蛋白斑块中神经节苷脂和蛋白质的空间分布映射研究
Christopher J Good,Andrew P Bowman,Corinna Klein et al.
Christopher J Good et al.
In pharmaceutical research and development, technologies like mass spectrometry imaging (MSI) offer spatially resolved compound distributions to aid in the discovery of drug targets and development of drug candidates. Through traditional an...
Transfer-Based Thin-Section-Free MALDI Mass Spectrometry Imaging Using a Platinum-Coated Porous Plate Formed of Glass Beads [0.03%]
基于转移的薄片无矩阵辅助激光解吸/电离质谱成像铂金涂层玻璃珠多孔板法
Takamasa Ikeda
Takamasa Ikeda
Matrix- and surface-assisted laser desorption/ionization mass spectrometry imaging (MALDI- and SALDI-MSI) are widely used for visualizing molecular distributions not only in medical and pharmaceutical applications but also in plant and food...
Real-Time Proton Transfer Reaction Mass Spectrometry for Pesticide Detection: A DFT-Based Feasibility Evaluation [0.03%]
基于DFT的农药检测实时质子转移反应气质联用法可行性研究
Yuliang Huang,Tong Yang,Chunguang Xie et al.
Yuliang Huang et al.
This feasibility study evaluates the application of proton transfer reaction mass spectrometry (PTR-MS) for the online measurement of pesticides. Although PTR-MS has established its efficacy in detecting volatile organic compounds, its pote...
Development and Validation of an UPLC-MS/MS Method for Simultaneous Quantification of Bisoprolol and Hydrochlorothiazide in Human Plasma [0.03%]
超高效液相色谱-串联质谱法测定人血浆中培洛尔和氢氯噻嗪的浓度及其验证
Asmaa Al-Asmar,Naim Kittana,Abdallatif Mayyala et al.
Asmaa Al-Asmar et al.
Bioanalytical method development and validation are essential for reliable quantification of drugs in biological matrices. This research focuses on developing and validating a UPLC-MS/MS method for the simultaneous determination of bisoprol...
Improved Annotation of Internal Fragments via Trapped-Ion Mobility Enhanced Top-Down Sequencing of Protein Ions [0.03%]
通过捕集离子淌度增强的顶部-down蛋白质离子序列改进内部片段注释
Katherine A Graham,Charles F Lawlor,Rachitha S Reddy et al.
Katherine A Graham et al.
Analysis of intact protein ions allows for valuable insights into complex biological processes. However, top-down mass spectrometry data is often convoluted and frequently results in numerous overlapping product ions. Ion mobility spectrome...
The Future of a Myriad of Accelerated Biodiscoveries Lies in AI-Powered Mass Spectrometry and Multiomics Integration [0.03%]
人工智能驱动的质谱及多组学整合将带来千万量级的生物发现机遇
Aivett Bilbao
Aivett Bilbao
The intersection of modern artificial intelligence (AI) and mass spectrometry (MS) is set to transform the MS-based "omics" research fields, particularly proteomics, metabolomics, lipidomics, and glycomics, enabling advancements across a wi...
MALDI-MS Analysis of Carbohydrates Using Ionic Liquid Matrices: Insights Into Ionization Efficiency and Sample Homogeneity [0.03%]
基于离子液体基质的MALDI-MS分析糖类：关于离子化效率和样品均一性的研究
Tobías Schmidt De León,María L Salum,Rosa Erra-Balsells
Tobías Schmidt De León
Since the introduction of ionic liquids matrices (ILMs) in MALDI-MS, they have demonstrated several advantages over crystalline matrices, including improved desorption/ionization efficiency and enhanced sample optical homogeneity. This stud...
GC/MS Investigation of the Reaction Products of Nitrogen Mustards and N,N-Dialkylaminoethyl-2-Chlorides With Phenol [0.03%]
氮芥和N,N-二烷基氨基乙基-2-氯化物与苯酚反应产物的GC/MS研究
K G Harsha,M Nikita Singh,A Veeresham et al.
K G Harsha et al.
The Chemical Weapons Convention (CWC)-scheduled chemicals that contain chlorine atom (e.g., mustards, aminoethyl-2-chlorides, and phosphorylchlorides) are highly reactive in environmental matrices, especially when they are in contact with p...
Fingerprint Analysis of Buriti (Mauritia flexuosa) Using Paper Spray Mass Spectrometry [0.03%]
采用纸喷雾质谱法分析buriti（ Mauritia flexuosa）指纹图谱
Bruna V Nunes,Ana Luiza C C Ramos,Talvane Coelho et al.
Bruna V Nunes et al.
A straightforward and efficient approach using paper spray ionization mass spectrometry (PS-MS) was employed to detect fixed constituents in all anatomical parts of buriti, a native Brazilian fruit. This ambient mass spectrometry technique ...