A Strategy to Achieve Sub-Parts-per-Million Mass Measurement Accuracy of N-Linked Glycans Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization [0.03%]
一种实现N连接聚糖红外基质辅助激光解吸电喷雾离子化的亚 ppm 质量测量准确度的策略
Adeleke A Adepoju,Tana V Palomino,Alexandria L Sohn et al.
Adeleke A Adepoju et al.
Mass calibration techniques are vital in achieving high mass measurement accuracy (MMA) of large biomolecules. Variable ion populations that shift the axial frequencies due to space charge effects have been a significant challenge in achiev...
Influence of Filters, Solid to Fluid Ratios and Matrices on the Bioaccessibility of Potentially Toxic Elements in Airborne PM [0.03%]
过滤器、固液比和基质对空气中PM潜在有毒元素生物可利用度的影响
Jawad Ali Hussein Alpofead,Christine M Davidson
Jawad Ali Hussein Alpofead
Determination of bioaccessibility of potentially toxic elements in inhaled airborne particulate matter has brought the attention of researchers. In this study, the effect of filters and solid-to-fluid ratios on the bioaccessible fraction of...
Mass Spectrometric Assessment of the Reactivity and Target Sites of 3-Aminopropanal and 3-Aminopropanal-Released Acrolein in Peptides and Proteins [0.03%]
3-氨基丙醛及其释放的丙烯醛与肽和蛋白质反应性的质量测定及靶位点分析
Michaela Rašková,Vlastimil Dorčák,Jan Vacek et al.
Michaela Rašková et al.
Living cells are frequently exposed to aldehydes, as these compounds are produced during metabolism, found in natural dietary sources, and present as contaminants, drugs, and pollutants. For instance, acrolein is well-known as a toxic pollu...
Deciphering the Pharmacodynamic Basis of Biyan Qingdu Granules: Integrated key Pharmacodynamic Components Identification, Multi-Tissue Distribution, and Metabolic Profiling [0.03%]
鼻炎清毒颗粒的药效物质基础研究：整合指标活性成分筛选、多组织分布及代谢组学 profiling 分析
Na Zhang,Xiang Fan,Fengyi Lv et al.
Na Zhang et al.
Biyan Qingdu Granules (BYQD) is a traditional Chinese medicine (TCM) formulation used to treat symptoms associated with increased secretion during nasopharyngeal carcinoma (NPC) radiotherapy. However, a comprehensive investigation into its ...
Stress Degradation Study of Bosutinib and Structural Elucidation of Its Degradation Impurities by Using LC-Q-TOF-MS/MS and NMR [0.03%]
基于LC-Q-TOF-MS/MS及NMR技术的博舒替尼应力降解研究及其降解杂质结构解析
Sowmya Chaganti,Usha Chauhan,Dharipally Harini et al.
Sowmya Chaganti et al.
Bosutinib monohydrate (BST) is an anticancer medicine used to treat Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia. The present research focuses on the separation and structural elucidation of degradation impurities of BST ...
Analysis of Acyl Solamines in Tuber Periderm of Cultivated and Wild Potatoes Using Liquid Chromatography Coupled With Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry [0.03%]
液相色谱-电喷雾四极杆飞行时间质谱分析栽培和野生马铃薯块茎周皮中酰胺类小分子化合物
Christoph Böttcher,Karin Gorzolka,Paul Himmighofen et al.
Christoph Böttcher et al.
Acyl solamines are a poorly investigated class of alkaloids found in several solanaceous plants. A general screening approach on the basis of all-ion fragmentation is proposed for this compound class using reversed-phase ultra-high performa...
Quantitative UHPLC-MS/MS Analysis of Gemcitabine and Its Active and Inactive Metabolites in Pig Plasma and Lung Tissue in Preparation of Locoregional Therapies for Non-Small Cell Lung Cancer [0.03%]
猪血浆和肺组织中吉西他滨及其活性代谢物和非活性代谢物的定量UHPLC-MS/MS分析为非小细胞肺癌的局部治疗做准备
Erik Claes,Jeroen M H Hendriks,Thérèse S Lapperre et al.
Erik Claes et al.
Gemcitabine (dFdC), an effective chemotherapeutic for non-small cell lung cancer (NSCLC), acts through its active metabolite, dFdCTP. Its current pharmacokinetics (PK) knowledge is based on intravenous infusion, which does not represent loc...
Evaluation of the Chemical Profile by Paper Spray Mass Spectrometry of Eugenia uniflora Pulp, Peel, Seeds, and Jelly [0.03%]
基于纸喷离子源质谱的杯葛果肉、皮、籽和果冻化学轮廓分析评价
Viviane D M Silva,Laiza A Nogueira,Ana Luiza C C Ramos et al.
Viviane D M Silva et al.
Pitangueira (Eugenia uniflora) is a fruit tree found in the Cerrado, Caatinga, and Atlantic Forest Brazilian biomes. Due to its intense and characteristic aroma and flavor, its fruits (Brazilian cherry) can be consumed raw and as an ingredi...
A Sensitive and Comprehensive LC-MS/MS Method for the Analysis of Hallucinogens, Synthetic Cathinones, and Synthetic Cannabinoids in Urine Samples [0.03%]
一种用于分析尿样中致幻剂、合成卡西酮和合成大麻素的灵敏且全面的LC-MS/MS方法
Bruno Pereira Dos Santos,Letícia Birk,Vítor Camargo Pôrto et al.
Bruno Pereira Dos Santos et al.
The laboratory analysis of new psychoactive substances and related drugs is crucial for accurate clinical and forensic diagnosis of poisonings. Given this, a new LC-MS/MS method for analyzing hallucinogens, synthetic cathinones, and synthet...