Unlocking the potential of unique genes in cyanobacterial alkane synthesis [0.03%]
蓝细菌产烷烃独特基因的挖掘与应用研究进展
Humaira Parveen,Vineesha Garg,Piyush Pachauri et al.
Humaira Parveen et al.
Alkanes are considered among the most promising candidates for next-generation biofuels. Amongst various pathways discovered for alkane production, the cyanobacterial AAR (acyl ACP reductase) - ADO (aldehyde deformylating oxygenase) pathway...
Joseph H Lynch,Shaunak Ray,Clint Chapple et al.
Joseph H Lynch et al.
2-Phenylethanol (2-PE) is a natural aromatic compound with properties that make it a potential biological oxygenate for petroleum-derived gasoline. In plants, 2-PE biosynthesis competes with the phenylpropanoid pathway for the common precur...
Elucidating the itaconic acid pathway dynamics in Saccharomyces cerevisiae [0.03%]
阐明酿酒酵母中的柠檬酸循环代谢路径动力学机制
Roy Eerlings,Tobias Karmainski,Andreas Müsgens et al.
Roy Eerlings et al.
Itaconic acid, a versatile platform chemical, has garnered significant attention due to its broad use in polymers, resins, and bio-based materials. Although fungi, especially Aspergillus and Ustilago, are the main producers of itaconic acid...
Engineering amino acid-derived malonyl-CoA pathways to boost polyketide production in Yarrowia lipolytica [0.03%]
工程改造天冬氨酸派和丙酮酸派脂肪酰辅酶A合成途径以提升酿酒酵母汉逊毕赤酵母聚酮体产量
Jinpeng Wang,Yuxiang Hong,Zizhao Wu et al.
Jinpeng Wang et al.
Malonyl-CoA is a central precursor involved in the synthesis of various bio-based chemicals, including polyketides, fatty acids, and flavonoids. However, the production of these chemicals is often limited by the availability of malonyl-CoA....
Metabolic engineering of Corynebacterium glutamicum for vitamin B12-independent production of 3-hydroxypropionic acid [0.03%]
用于独立生产3-羟基丙酸的安琪雅链霉菌代谢工程学研究
Cheon Woo Moon,Mohammad Rifqi Ghiffary,Cindy Pricilia Surya Prabowo et al.
Cheon Woo Moon et al.
3-Hydroxypropionic acid (3-HP) is a versatile platform chemical with broad applications, serving as a precursor for the synthesis of value-added chemicals as well as the biodegradable polymers. However, current industrial production of 3-HP...
Redefining HexR regulatory landscape in Pseudomonas putida KT2440 through integrative systems biology [0.03%]
整合系统生物学重新定义恶臭假单胞菌KT2440的HexR调控景观
Linh Khanh Nong,Chandran Sathesh-Prabu,Sung Kuk Lee et al.
Linh Khanh Nong et al.
Pseudomonas putida strains are prized biocatalysts, renowned for their versatility in degrading diverse chemicals, tolerating organic solvents, and withstanding environmental stressors. Central to their adaptive success is the precise regul...
Corrigendum to "Microbial production of propionic acid through a novel β-alanine route" [Metabol. Eng. (2026) 219-231 93] [0.03%]
关于“通过新型β-丙氨酸途径微生物生产丙酸”一文的勘误(卷93页219-231)[代谢工程(2026) 219-231 93]
Da-Hee Ahn,Yoo-Sung Ko,Cindy Pricilia Surya Prabowo et al.
Da-Hee Ahn et al.
Published Erratum
Metabolic engineering. 2025 Nov 11:94:35. DOI:10.1016/j.ymben.2025.11.008 2025
Engineered plants for the production of the antioxidants arbutin and gallate [0.03%]
用于抗氧化物熊果苷和棓酸生产的工程植物
Sami Kazaz,Yu-Ton Chen,Senri Yamamoto et al.
Sami Kazaz et al.
The shikimate pathway is a crucial metabolic route for the biosynthesis of numerous valuable chemicals. In this study, we engineered the shikimate pathway in plants via expression of microbial enzymes to produce the two important antioxidan...
Advancing arabinose-based bioproduction in Yarrowia lipolytica by integrating metabolic engineering and adaptive laboratory evolution [0.03%]
利用代谢工程和实验进化法在解脂耶氏酵母中推进木糖基生物生产工艺
Razieh Rafieenia,Jing Fu,Piotr Hapeta et al.
Razieh Rafieenia et al.
The oleaginous yeast, Yarrowia lipolytica has gained interest as a biotechnological chassis to produce foods, chemicals, pharmaceuticals, and biofuels. To reduce production costs and sustainability, inexpensive and abundant feedstocks such ...
Predictive CRISPR-mediated gene downregulation for enhanced production of sustainable aviation fuel precursor in Pseudomonas putida [0.03%]
预测性CRISPR介导的基因低表达促进假单胞菌中可持续航空燃料前体的有效产生的方法
Ian S Yunus,David N Carruthers,Yan Chen et al.
Ian S Yunus et al.
CRISPR interference (CRISPRi) has emerged as a valuable tool for redirecting metabolic flux to enhance bioproduction. However, its application is often constrained by two challenges: (i) rationally identifying effective gene targets for dow...