Autoimmune disease and cancer comorbidity: Current understandings of immune-mediated pathogenesis and treatment [0.03%]
自身免疫性疾病与癌症共病：当前介导免疫病理和治疗的理解
Md Asiful Islam,Mohammad Amjad Kamal,Siew Hua Gan et al.
Md Asiful Islam et al.
Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy [0.03%]
抗癌治疗脂质体递送系统开发中的挑战与陷阱分析
Seyedeh Alia Moosavian,Vanessa Bianconi,Matteo Pirro et al.
Seyedeh Alia Moosavian et al.
Despite considerable advances in the application of liposomal drug delivery systems in cancer treatment, the clinical application of liposomal formulations has been limited by many factors. It seems that there is a wide gap between results ...
The molecular biology of pancreatic neuroendocrine neoplasms: Challenges and translational opportunities [0.03%]
胰腺神经内分泌肿瘤的分子生物学：挑战与转化机遇
Kate Young,Naureen Starling,Anguraj Sadanandam
Kate Young
Pancreatic neuroendocrine neoplasms (PanNENs) are rare, highly heterogeneous tumours. There have been significant recent advances in our knowledge of genomic events underlying their pathogenesis. However, treatment decisions remain largely ...
Systems biology based drug repositioning for development of cancer therapy [0.03%]
基于系统生物学的药物再定位在癌症治疗中的应用与发展
Beste Turanli,Ozlem Altay,Jan Borén et al.
Beste Turanli et al.
Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication. The first examples of repurposed drugs were discovered ...
Exploiting epigenetic vulnerabilities in solid tumors: Novel therapeutic opportunities in the treatment of SWI/SNF-defective cancers [0.03%]
利用表观遗传易感性治疗实体瘤：SWI/SNF缺陷型癌症治疗中的新机遇
Roman M Chabanon,Daphné Morel,Sophie Postel-Vinay
Roman M Chabanon
Mammalian switch/sucrose non-fermentable (mSWI/SNF) family complexes are pivotal elements of the chromatin remodeling machinery, which contribute to the regulation of several major cellular functions. Large-scale exome-wide sequencing studi...
New insights in melanoma biology: Running fast towards precision medicine [0.03%]
黑色素瘤研究新进展：走向精准医疗的路上奋勇向前
Patrizia Limonta,Paola Queirolo
Patrizia Limonta
Computer-aided drug repurposing for cancer therapy: Approaches and opportunities to challenge anticancer targets [0.03%]
计算辅助药物再定位在癌症治疗中的应用：对抗癌症靶点的挑战与机遇
Carla Mottini,Francesco Napolitano,Zhongxiao Li et al.
Carla Mottini et al.
Despite huge efforts made in academic and pharmaceutical worldwide research, current anticancer therapies achieve effective treatment in a limited number of neoplasia cases only. Oncology terms such as big killers - to identify tumours with...
Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer [0.03%]
非小细胞肺癌中罕见的表皮生长因子受体(EGFR)突变
Peter T Harrison,Simon Vyse,Paul H Huang
Peter T Harrison
Epidermal growth factor receptor (EGFR) mutations are the second most common oncogenic driver event in non-small cell lung cancer (NSCLC). Classical activating mutations (exon 19 deletions and the L858R point mutation) comprise the vast maj...
Derek B Oien,Christopher L Pathoulas,Upasana Ray et al.
Derek B Oien et al.
Quinacrine, also known as mepacrine, has originally been used as an antimalarial drug for close to a century, but was recently rediscovered as an anticancer agent. The mechanisms of anticancer effects of quinacrine are not well understood. ...
Nanotechnological based miRNA intervention in the therapeutic management of neuroblastoma [0.03%]
基于纳米技术的miRNA干预在神经母细胞瘤治疗中的作用
Faheem Hyder Pottoo,Md Abul Barkat,Harshita et al.
Faheem Hyder Pottoo et al.
Neuroblastoma (NB) is a widely diagnosed cancer in children, characterized by amplification of the gene encoding the MYCN transcription factor, which is highly predictive of poor clinical outcome and metastatic disease. microRNAs (a class o...