Tumor microenvironment evaluation in lung cancer: Spatio-temporal dynamics and clinical implications [0.03%]
肺癌肿瘤微环境评价：时空动态及临床意义
Selma Dizdarević,Oleg Timofeev,Daniel Kazdal et al.
Selma Dizdarević et al.
The treatment of non-small cell lung cancer (NSCLC), a disease known for its aggressiveness and significant global impact, has substantially improved in recent decades. A notable shift from cytotoxic chemotherapy to more personalized approa...
Wencheng Shi,Boyang Song,Shenglong Xia et al.
Wencheng Shi et al.
Obesity is an established risk factor for at least thirteen cancer types, yet the mechanisms by which the gut microbiota participates in obesity-related tumorigenesis remain incompletely understood. In this review, we summarize the role of ...
Larry Mansouri,Thomas Chatzikonstantinou,Lydia Scarfò et al.
Larry Mansouri et al.
Chronic lymphocytic leukemia (CLL) is a paradigmatic malignancy driven by intraclonal diversity and dynamic evolutionary processes. High-resolution genomic profiling has demonstrated that CLL progression rarely follows a linear trajectory; ...
Bridging the gap between tumor evolution and clonality diagnostics in multiple lung carcinomas [0.03%]
多重肺癌中肿瘤进化与克隆诊断之间的联系
Jurriaan Janssen,Michael Allgäuer,Bauke Ylstra et al.
Jurriaan Janssen et al.
Differentiating multiple primary lung carcinomas (MPLCs) from intrapulmonary metastases (IPMs) remains a critical challenge in the management of patients with multiple non-small cell lung carcinomas (NSCLCs). Although the clinical presentat...
Mitochondria in sarcoma and carcinoma: Achilles' heel or Hercules' strength? [0.03%]
线粒体在肉瘤和癌中的作用：阿喀琉斯之踵还是赫拉克勒斯之勇？
Mohammad Reza Ashrafi,Laure Cayrefourcq,Sadegh Rajabi et al.
Mohammad Reza Ashrafi et al.
Sarcomas and carcinomas represent approximately 1% and 80% of all cancer diagnoses, respectively. Despite their very different prevalence, both tumor types share a critical dependence on mitochondrial functions for metabolic adaptation, sur...
Obesity-focused dietary interventions in breast cancer care: A comprehensive review of medical nutrition therapy approaches and efficacy in prevention and treatment [0.03%]
以饮食干预为中心的乳腺癌护理：医学营养治疗在预防和治疗肥胖中的作用及疗效综合评价
Claudia Reytor-González,Evelyn Frias-Toral,Giuseppe Annunziata et al.
Claudia Reytor-González et al.
Obesity is associated with an increased risk of developing breast cancer, particularly in postmenopausal women, through mechanisms such as excessive estrogen production, insulin resistance, and chronic low-grade inflammation, all of which p...
Julio Buñay,Silia Ayadi,Chloe Gressein et al.
Julio Buñay et al.
Oxysterols are enzymatically or non-enzymatically generated cholesterol derivatives that act as metabolic messengers at the interface of lipid homeostasis, nuclear receptor signaling, oxidative stress, and immunity. Their structural diversi...
Simona Cernea,Dana Crişan,Cristina-Mihaela Lăcătuşu et al.
Simona Cernea et al.
Obesity and type 2 diabetes mellitus are increasingly recognized as important risk factors for cancer development and progression, including cancers of the digestive system. Indeed, epidemiologic evidence demonstrated that both conditions i...
The biology and evolution of Richter transformation in chronic lymphocytic leukemia [0.03%]
慢性淋巴细胞白血病中里希特转化的生物学和进化过程
Ferran Nadeu,Dimitar G Efremov
Ferran Nadeu
Richter transformation (RT) is a relatively rare but clinically challenging event in the natural history of chronic lymphocytic leukemia (CLL), characterized by the abrupt transformation of CLL into an aggressive lymphoma, most commonly dif...
Intratumor Heterogeneity and Clonal Evolution in Sarcomas: Molecular, Cellular, and Functional Drivers of Therapy Resistance [0.03%]
软组织肉瘤的肿瘤内异质性和克隆演化：治疗抵抗的分子、细胞和功能驱动因素
Thomas G P Grünewald,Ina Oehme,Johanna Wagner et al.
Thomas G P Grünewald et al.
Sarcomas, malignant neoplasms of mesenchymal origin, comprise more than 100 entities and numerous histologic subtypes. Their relative rarity compared with carcinomas, interpatient diversity, and pronounced intratumor heterogeneity (ITH) mak...