Clonal dynamics on the road to hematological malignancy (MBL, MGUS, CH) [0.03%]
向血液系统恶性肿瘤（MBL，MGUS，CH）演变过程中的克隆动态学
Xie Zhuoer,Sekar Aswin,Ghia Paolo et al.
Xie Zhuoer et al.
Monoclonal gammopathy of undetermined significance (MGUS), monoclonal B-cell lymphocytosis (MBL), and clonal hematopoiesis (CH) of indeterminate potential represent highly prevalent, age-associated precursor states characterized by detectab...
Evolutionary and resistance dynamics in oligometastatic and oligoprogressive cancer treated with stereotactic radiotherapy and systemic therapies: a systematic review and focused meta-analysis [0.03%]
立体定向放射治疗和系统性治疗寡转移和寡进展癌症的进化和抵抗动态：系统评价和集中型meta分析
Marilina García-Aranda,Juan Zafra-Martín,Alba Rodríguez-Martínez et al.
Marilina García-Aranda et al.
Background: Oligometastatic and oligoprogressive disease treated with stereotactic ablative radiotherapy (SABR) represents a clinically heterogeneous entity. Increasing evidence suggests that anatomical definitions alone ...
Beyond the traditional dish: advanced 3D ex vivo culture platforms for tumor modelling [0.03%]
超越传统方法：肿瘤建模的先进体外三维培养平台
Konstantina Strepi,Roos F Koppenol,Jos Jonkers et al.
Konstantina Strepi et al.
The tumor microenvironment (TME) and its complex, dynamic interactions play a pivotal role in cancer development, progression and therapy response. However, faithful recapitulation of the diverse cellular and structural components of the TM...
Interplay between DNA and RNA methylation shapes cancer cell plasticity [0.03%]
DNA和RNA甲基化互作调控肿瘤细胞的可塑性
Guglielmo Bove,Ugo Chianese,Antonio Beato et al.
Guglielmo Bove et al.
Cellular plasticity refers to the ability of healthy cells to shift between phenotypic states and modify their characteristics to maintain tissue homeostasis and integrity. In the tumor context, cancer stem cells (CSCs) exploit this flexibi...
Lin-Lin Bu,Quanyin Hu
Lin-Lin Bu
Wafa Khalil,Haicheng Song,Ziwei Li et al.
Wafa Khalil et al.
The oral microbiome is comparable to the gut microbiome in ecological complexity and is now recognized as a contributor to anticancer immune responses. Although the relationship between the gut microbiome and anticancer immunity is well est...
Unveiling tumor heterogeneity by single cell RNA-sequencing: From basic considerations to clinical applications [0.03%]
单细胞RNA测序揭示肿瘤异质性：从基本考虑至临床应用
Tina Fuchs,Michael Menzel,Katharina Mößinger et al.
Tina Fuchs et al.
Tumor heterogeneity-encompassing diverse cellular phenotypes, genomic alterations, and microenvironmental contexts-is a principal barrier to effective cancer therapy. Single-cell RNA sequencing (scRNA-seq) has transformed our ability to res...
Hidden Architecture of Resistance: The Extracellular Matrix in Melanoma's Immune Landscape [0.03%]
隐秘的抵抗架构：黑色素瘤免疫景观中的细胞外基质
Yimeng Guan,Gisella Edny,Janin Chandra et al.
Yimeng Guan et al.
Tumor heterogeneity in cutaneous melanoma (CM) is attributed to the functional and structural diversity of tumor cells, immune cells, and the tumor stroma, and determines patients' response to therapy. The tumor immune microenvironment (TIM...
Microfluidic Technologies for Extracellular Vesicle Isolation and Analysis: Implications for Translational Applications in Cancer Therapy [0.03%]
微流体技术在细胞外囊泡分离和分析中的应用及对癌症治疗的转化意义
Fabrizio Mattei,Adriana Rosa Gambardella,Francesco Noto et al.
Fabrizio Mattei et al.
Extracellular vesicles (EVs) are emerging as pivotal mediators of tumor progression, metastasis, and therapy resistance, reflecting the dynamic complexity of the tumor microenvironment. Their stability in biofluids makes EVs promising candi...
Exploring glioblastoma microenvironment using organoids: opportunities, limitations, and emerging concepts [0.03%]
类器官在胶质母细胞瘤微环境研究中的应用：机遇、局限性和新兴概念
Anuja Lipsa,Gaëlle Triballier,Anna Golebiewska
Anuja Lipsa
Glioblastoma (GBM) remains the most lethal primary brain tumor in adults. These aggressive tumors evolve as dynamic, spatially organized ecosystems in which tumor cells continuously interact with the surrounding brain parenchyma and systemi...