Cancer therapy-related cardiovascular toxicity: Current progress and future perspectives [0.03%]
癌症治疗相关心血管毒性：当前进展与未来展望
Hongcai Shang,William Cho,Yanwei Xing
Hongcai Shang
Microbiome-modulated immunotherapy in oncology: Current applications and future prospects [0.03%]
肿瘤学中的微生物组调节免疫疗法：当前应用和未来前景
Yu Liu,Keyan Miao,Xi Yang
Yu Liu
Cancer immunotherapy has transformed oncology, yet therapeutic efficacy remains heterogeneous and frequently limited by primary or acquired resistance. Increasing evidence demonstrates that both intra- and extratumoral microbiota critically...
Lipid metabolic alterations in cancer: common pathophysiology with cardiovascular disease [0.03%]
癌症中的脂质代谢改变：与心血管疾病的共同病理生理学
Maria Llena-Meler,Alberto Canfran-Duque,Julio Madrigal-Matute et al.
Maria Llena-Meler et al.
Obesity-induced chronic inflammation and lipid metabolic imbalance form a pivotal nexus linking cardiovascular disease and cancer. Dysfunctional adipose tissue establishes a pro-inflammatory environment through hypoxia-driven macrophage pol...
Integrative spatial omics and artificial intelligence: transforming cancer research with omics data and AI [0.03%]
整合型空间组学与人工智能：利用组学数据和AI变革癌症研究
Maddison McKenzie,Sergio Erdel Irac,Zhian Chen et al.
Maddison McKenzie et al.
The integration of multi-omics data, including genomics, transcriptomics, proteomics, epigenomics, and metabolomics, coupled with histological spatial data has transformed biomedical research, offering unprecedented insights into cellular f...
Lipid Dysregulation in Renal Cancer: Drivers of Tumor Growth and Determinants of Treatment-Induced Toxicity [0.03%]
脂质失调在肾癌中的作用：促进肿瘤生长和决定治疗诱导的毒性的因素
Mohammed Alnukhali,Alessia Fornoni,Alan Pollack et al.
Mohammed Alnukhali et al.
Background: Clear cell renal cell carcinoma (ccRCC) exhibits a distinctive metabolic signature marked by the excessive buildup of cholesterol and neutral lipids. This phenotype stems largely from the loss of the von Hippe...
Spatial Multi-Omics in Precision Medicine: Integrating Biological Insights Through Multidisciplinary Collaboration [0.03%]
精准医学中的空间多组学：通过跨学科合作整合生物学见解
Da Yeon Kim,Jeeyong Lee,Jiwon Choi et al.
Da Yeon Kim et al.
Spatial multi-omics has emerged as a transformative approach in biomedical research, enabling the integration of diverse molecular modalities while preserving their native spatial contexts. This review provides an overview of spatial multi-...
Hiroyuki Inuzuka,Wenyi Wei
Hiroyuki Inuzuka
Celestina Agyemang-Dua,Charles S Chung,Cristina Espinosa-Diez
Celestina Agyemang-Dua
Cancer therapies save lives but often "break hearts" by damaging the cardiovascular system. As survival improves, therapy-induced cardiotoxicity has become a defining challenge of modern oncology. Recent discoveries reveal that long non-cod...
Immune checkpoint inhibitor-induced myocarditis: focus on the downstream pathogenic components and potential therapeutics [0.03%]
免疫检查点抑制剂诱导的心肌炎：下游病原成分及潜在治疗方法:focus on the downstream pathogenic components and potential therapeutics
Yifan Chen,Xuejun Wang,Yihui Shen et al.
Yifan Chen et al.
Advent of immune checkpoint inhibitors (ICIs) has renovated onco-immunotherapy, with around 50% of cancer patients suitable for the treatment. However, patients treated by ICIs are in jeopardy for immune-related adverse events (irAEs) that ...
M Boschetti,I Hasballa,I Patelli et al.
M Boschetti et al.
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) comprise a heterogeneous group of tumors differing according to the primary lesion site, histological features, clinical status and prognosis. The etiopathogenesis of GEP-NEN is not ...