George Xie,Sho Okuda,Jing-Yan Gao et al.
George Xie et al.
The prolyl-isomerase Pin1 is a unique enzyme that catalyzes cis-trans isomerization of phosphorylated Ser/Thr-Pro motifs. These motifs are present in many proteins, where isomerization of the typically rigid prolyl-peptide bond can lead to ...
Impact of obesity on postoperative complications in colorectal cancer surgery: A systematic review and meta-analysis [0.03%]
肥胖对结直肠癌术后并发症影响的系统评价和 Meta 分析
Gerardo Sarno,Daniel Simancas-Racines,Antonio Gargiulo et al.
Gerardo Sarno et al.
Background: Obesity has been increasingly recognized as a factor that influences postoperative outcomes in colorectal cancer surgery. However, its impact on surgical complications, mortality, and oncological outcomes rema...
The intricate role of adipokines in cancer-related signaling and the tumor microenvironment: Insights for future research [0.03%]
脂肪细胞因子在癌症相关信号传导和肿瘤微环境中的复杂作用：未来研究的新见解
Dimitris Kounatidis,Natalia G Vallianou,Irene Karampela et al.
Dimitris Kounatidis et al.
Obesity represents a global health challenge, with adipose tissue acting as a highly active endocrine organ that synthesizes and secretes a diverse array of bioactive proteins, known as adipokines. These cell signaling molecules regulate me...
T-Cell Senescence: Unlocking the Tumor Immune "Dark Box" - A Multidimensional Analysis from Mechanism to Tumor Immunotherapeutic Intervention [0.03%]
T细胞衰老：解锁肿瘤免疫“暗箱”——从机制到肿瘤免疫干预的多维度分析
Jia Cheng,Jian Zheng,Chen Ma et al.
Jia Cheng et al.
Immunosenescence is the dysfunction of the immune system that occurs with age, a process that is complex and characterized by several features, of which T-cell senescence is one of the key manifestations. In the tumor microenvironment, sene...
Genomic instability, DNA damage response and telomere homeostasis in pancreatic cancer [0.03%]
胰腺癌的基因组不稳定、DNA损伤反应及端粒动态平衡
Saba Selvi,Carmen Macías Real,Manuel Gentiluomo et al.
Saba Selvi et al.
Pancreatic cancer (PC) is becoming one of the most serious health problems at present, but its causes and risk factors are still unclear. One of the drivers in pancreatic carcinogenesis is altered genomic (DNA) integrity with subsequent gen...
The potential application of stroma modulation in targeting tumor cells: focus on pancreatic cancer and breast cancer models [0.03%]
肿瘤间质调控在肿瘤细胞靶向治疗中的潜在应用：重点研究胰腺癌和乳腺癌模型
Giuseppina Roscigno,Sacha Jacobs,Belen Toledo et al.
Giuseppina Roscigno et al.
The tumor microenvironment (TME) plays a crucial role in cancer development and spreading being considered as "the dark side of the tumor". Within this term tumor cells, immune components, supporting cells, extracellular matrix and a myriad...
The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC [0.03%]
暴露组学与胰腺癌、PDAC的生活方式及环境风险因素
Giulia Peduzzi,Livia Archibugi,Riccardo Farinella et al.
Giulia Peduzzi et al.
Pancreatic cancer (PC), particularly pancreatic ductal adenocarcinoma (PDAC), is a significant global health issue with high mortality rates. PDAC, though only 3% of cancer diagnoses, causes 7% of cancer deaths due to its severity and asymp...
HDAC inhibitors: Cardiotoxicity and paradoxical cardioprotective effect in ischemia-reperfusion myocardiocyte injury [0.03%]
组蛋白去乙酰化酶抑制剂与缺血/再灌注损伤心肌细胞的护心和伤心作用
Kenneth K W To,Seda Tolu,Longling Wang et al.
Kenneth K W To et al.
Histone deacetylase inhibitors (HDACIs) are epigenetic drugs that regulate the acetylation status of histones and non-histone proteins, thereby leading to chromatin remodeling and transcriptional regulation of key apoptotic and cell cycle r...
Metabolic Reprogramming in Cancer Therapy-Related Cardiovascular Toxicity: Mechanisms and Intervention Strategies [0.03%]
癌症治疗相关心血管毒性的代谢重构：机制和干预策略
Cheng Zeng,Ying Gao,Bo Lan et al.
Cheng Zeng et al.
Cancer therapy-related cardiovascular toxicity (CTR-CVT) poses a major challenge in managing cancer patients, contributing significantly to morbidity and mortality among survivors. CTR-CVT includes various cardiovascular issues, such as car...
Yinglin Huang,Yuhong Zhan,Yuhua Zhan
Yinglin Huang
Diagnosis and treatment of cancer constitute a deeply stressful experience that involves unique and common problems and generates uncertainty, fear and emotional distress. Furthermore, there are reciprocal interactions between psychological...