Yusha Wang,Jing Huang,Huan Tong et al.
Yusha Wang et al.
The gut microbiota is essential in colorectal cancer (CRC) development, progression, and therapeutic responsiveness through its metabolic acquisitions and immunomodulatory functions. The composition of gut microbiota is shaped by habitat fi...
Emmanuel Jacobo-Tovar,Andrea Medel-Sánchez,Cosette Durán-Castillo et al.
Emmanuel Jacobo-Tovar et al.
Obesity-associated insulin resistance (IR) is characterized by a chronic low-grade inflammatory state driven by adipocyte dysfunction, elevated free fatty acids, and proinflammatory cytokines. These factors activate signaling pathways-inclu...
Navigating the Paradox of Senescence and Chemoresistance in Pancreatic Cancer [0.03%]
胰腺癌中衰老与化疗耐药性的悖论及应对策略
Amal Jeiroshi,Juan Deng,Ziyao Xu et al.
Amal Jeiroshi et al.
Cellular senescence, described as a mechanism of irreversible cell cycle arrest, has emerged as a complex and multifaceted process with significant implications in cancer biology, particularly in pancreatic ductal adenocarcinoma (PDAC). Thi...
The Converging Roles of microRNAs and Lipid Metabolism in Atherosclerotic Cardiovascular Disease and Cancer [0.03%]
microRNA与脂质代谢在动脉粥样硬化性心血管疾病和癌症中作用的汇聚
Sandra Vladimirov,Marija Tomaševic,Nemanja Popov et al.
Sandra Vladimirov et al.
Cancer and atherosclerotic cardiovascular disease (ASCVD) are the main causes of mortality worldwide. The complex relationship between these two diseases has long puzzled scientists, with lipid metabolism emerging as a promising area for re...
"Weighty Matters: Unraveling the Impact of Obesity on Colorectal Cancer and Nutritional Interventions" [0.03%]
"肥胖与结直肠癌的影响及营养干预的研究"
Daniel Simancas-Racines,Claudia Reytor-González,Evelyn Frias-Toral et al.
Daniel Simancas-Racines et al.
This narrative review explores the influence of obesity on colorectal cancer, focusing on obesity-related factors, including chronic inflammation, metabolic dysregulation, and gut microbiota imbalance, which collectively create a pro-carcin...
"Time" for obesity-related cancers: the role of chrononutrition in cancer prevention and treatment [0.03%]
时间与肥胖相关癌症：营养定时在癌症预防和治疗中的作用
Ludovica Verde,Martina Galasso,Silvia Savastano et al.
Ludovica Verde et al.
Obesity-related cancers are increasing globally, driven by metabolic disturbances and circadian rhythm disruptions. Circadian rhythms regulate physiological processes, and their misalignment has been linked to increased cancer risk. Chronon...
Long-term recurrence of PDAC after resection for IPMN: a narrative review of the literature on clinical and biologic predictors [0.03%]
IPMN术后胰腺导管腺癌长期复发：临床和生物学预测因素的文献综述
Annalisa Comandatore,Gregorio Di Franco,Ingrid Garajová et al.
Annalisa Comandatore et al.
Recurrence of IPMNs after surgical resection is defined as the reappearance of new cystic lesions, invasive carcinoma, or metastases, either in the remnant pancreas or other distant sites. The median 5-year cumulative incidence of residual ...
George Xie,Sho Okuda,Jing-Yan Gao et al.
George Xie et al.
The prolyl-isomerase Pin1 is a unique enzyme that catalyzes cis-trans isomerization of phosphorylated Ser/Thr-Pro motifs. These motifs are present in many proteins, where isomerization of the typically rigid prolyl-peptide bond can lead to ...
Impact of obesity on postoperative complications in colorectal cancer surgery: A systematic review and meta-analysis [0.03%]
肥胖对结直肠癌术后并发症影响的系统评价和 Meta 分析
Gerardo Sarno,Daniel Simancas-Racines,Antonio Gargiulo et al.
Gerardo Sarno et al.
Background: Obesity has been increasingly recognized as a factor that influences postoperative outcomes in colorectal cancer surgery. However, its impact on surgical complications, mortality, and oncological outcomes rema...
The intricate role of adipokines in cancer-related signaling and the tumor microenvironment: Insights for future research [0.03%]
脂肪细胞因子在癌症相关信号传导和肿瘤微环境中的复杂作用：未来研究的新见解
Dimitris Kounatidis,Natalia G Vallianou,Irene Karampela et al.
Dimitris Kounatidis et al.
Obesity represents a global health challenge, with adipose tissue acting as a highly active endocrine organ that synthesizes and secretes a diverse array of bioactive proteins, known as adipokines. These cell signaling molecules regulate me...