Cancer prevention and interception with antidiabetic and anti-obesity drugs: current and future perspectives [0.03%]
抗癌与拦截：抗糖尿病和抗肥胖症药物的当前及未来前景
Adriana Albini,Anna Rita Cantelmo,Lorenzo Mortara et al.
Adriana Albini et al.
Obesity and type 2 diabetes are major risk factors for cardiovascular diseases and multiple malignancies, and epidemiology reveals an increasing burden of obesity-related cancers,in particular liver, pancreatic and endometrial. Obesity is a...
Caterina Miro,Annunziata Gaetana Cicatiello,Monica Dentice et al.
Caterina Miro et al.
Deiodinases are key regulators of Thyroid Hormone (TH) bioavailability, exerting a precise spatial and temporal control over T3 levels in peripheral tissues. By dynamically modulating TH activation and inactivation, deiodinases allow target...
CRISPR/Cas9 genome engineering in PDAC: from preclinical studies to translation and clinical research [0.03%]
基于CRISPR/Cas9的胰腺癌基因组编辑技术：从基础研究到临床转化和应用
Yanxi Lu,Jojanneke Stoof,Yaba Rosette Tanoé et al.
Yanxi Lu et al.
CRISPR/Cas9 technology has emerged as a powerful tool in pancreatic ductal adenocarcinoma cancer (PDAC) research, facilitating the study of genes involved in cell signaling pathways, proliferation, migration, invasion, and chemotherapy resi...
Bahadır Köylü,Cem Sulu,Volkan Demirhan Yumuk et al.
Bahadır Köylü et al.
Sarcopenic obesity is a distinct clinical condition characterized by the coexistence of excess fat and reduced muscle mass. Although the prevalence of sarcopenic obesity varies depending on the definition used, it is increasingly recognized...
Aman Wang,Jiwei Liu
Aman Wang
Cardio-oncology is an emerging interdisciplinary field focused on the intersection of cancer and cardiovascular disease. With the rising incidence of both cancer and cardiovascular disease in China, establishing a strong cardio-oncology fra...
Reopening Pandora's box: is there a role for HDL in breast cancer? [0.03%]
开启潘多拉的盒子：高密度脂蛋白在乳腺癌中有作用吗？
Maria Isabela Alves Caldas Sawada,Monique de Fátima de Mello Santana,Milena Gomes Vancini et al.
Maria Isabela Alves Caldas Sawada et al.
Plasma lipid and lipoprotein profiles are recognized as key modulators in breast cancer (BC) development. Notably, the association between high-density lipoprotein cholesterol (HDLc) and BC remains controversial, with studies reporting posi...
Advances and mechanisms of gut microbiota modulation in enhancing immune checkpoint inhibitor efficacy [0.03%]
调节肠道菌群增强免疫检查点抑制剂疗效的进展与机制研究
Li Chen,Baoyi Li,Menghang Zu et al.
Li Chen et al.
The gut microbiota is crucial for maintaining human health by regulating immune homeostasis and metabolic function. Immune checkpoint inhibitors (ICIs) have emerged as a cornerstone of cancer immunotherapy, yet their effectiveness is often ...
Navigating the weight: The impact of obesity on gastrointestinal cancer surgery and strategies for improved outcomes [0.03%]
肥胖对胃肠道癌症手术的影响及改善结局的策略分析
Gerardo Sarno,Claudia Reytor-González,Evelyn Frias-Toral et al.
Gerardo Sarno et al.
Obesity significantly affects gastrointestinal cancer surgery outcomes by creating complex challenges throughout the preoperative, intraoperative, and postoperative stages. This narrative review explores the intricate relationship between o...
The microbiome-immune cell interaction network: Advancing tumor immunotherapy [0.03%]
肿瘤免疫治疗中的微生物组-免疫细胞交互网络研究进展
Wei Liu,Zhou Lan,Zhenzi Lin et al.
Wei Liu et al.
Tumor immunotherapy has achieved revolutionary advancements; however, owing to the complex interplay of multiple intrinsic and extrinsic tumor factors, the patient response rate remains suboptimal. Recent research has emphasized the pivotal...
Lipids and lipoproteins in the interstitial tissue fluid regulate the formation of dysfunctional tissue-resident macrophages: implications for atherogenic, tumorigenic, and obesogenic processes [0.03%]
组织间液中的脂质和脂蛋白调节功能失调的驻留巨噬细胞的形成：对动脉粥样硬化、肿瘤发生和肥胖过程的意义
Miriam Lee-Rueckert,Matti Jauhiainen,Petri T Kovanen et al.
Miriam Lee-Rueckert et al.
An inflammatory and lipid-enriched tissue microenvironment is a common characteristic of the extracellular niches of affected tissues in atherosclerosis, cancer, and obesity. These respective interstitial environments appear to be induced b...