D A Lamabadusuriya,H Jayasena,A K Bopitiya et al.
D A Lamabadusuriya et al.
Obesity is a growing global health challenge, significantly increasing the risk of metabolic diseases and cancer. This review explores the link between obesity-driven inflammation and cancer risk, emphasizing the key biological mechanisms. ...
Xiao-Feng Xu,Jin-Long Cui,Wen-Hua Li et al.
Xiao-Feng Xu et al.
Immunotherapy for genitourinary cancer, including bladder cancer, renal cell carcinoma, and prostate cancer, has made significant progress in recent years; however, it still faces challenges such as low patient response rates, drug resistan...
Landscape of non-coding RNAs in cancer treatment-induced cardiovascular toxicity: from mechanistic insights to clinical implications [0.03%]
癌症治疗诱导的心血管毒性的非编码RNA景观：从机制见解到临床意义
Yayu Chen,Zhishuang Ye,Rong-Quan He et al.
Yayu Chen et al.
Non-coding RNAs (ncRNAs) are increasingly recognized as crucial regulators in the pathophysiology of cancer treatment-induced cardiovascular toxicity, which largely stems from their capacity to orchestrate a wide range of gene expression ne...
Cancer prevention and interception with antidiabetic and anti-obesity drugs: current and future perspectives [0.03%]
抗癌与拦截：抗糖尿病和抗肥胖症药物的当前及未来前景
Adriana Albini,Anna Rita Cantelmo,Lorenzo Mortara et al.
Adriana Albini et al.
Obesity and type 2 diabetes are major risk factors for cardiovascular diseases and multiple malignancies, and epidemiology reveals an increasing burden of obesity-related cancers,in particular liver, pancreatic and endometrial. Obesity is a...
Caterina Miro,Annunziata Gaetana Cicatiello,Monica Dentice et al.
Caterina Miro et al.
Deiodinases are key regulators of Thyroid Hormone (TH) bioavailability, exerting a precise spatial and temporal control over T3 levels in peripheral tissues. By dynamically modulating TH activation and inactivation, deiodinases allow target...
CRISPR/Cas9 genome engineering in PDAC: from preclinical studies to translation and clinical research [0.03%]
基于CRISPR/Cas9的胰腺癌基因组编辑技术：从基础研究到临床转化和应用
Yanxi Lu,Jojanneke Stoof,Yaba Rosette Tanoé et al.
Yanxi Lu et al.
CRISPR/Cas9 technology has emerged as a powerful tool in pancreatic ductal adenocarcinoma cancer (PDAC) research, facilitating the study of genes involved in cell signaling pathways, proliferation, migration, invasion, and chemotherapy resi...
Bahadır Köylü,Cem Sulu,Volkan Demirhan Yumuk et al.
Bahadır Köylü et al.
Sarcopenic obesity is a distinct clinical condition characterized by the coexistence of excess fat and reduced muscle mass. Although the prevalence of sarcopenic obesity varies depending on the definition used, it is increasingly recognized...
Aman Wang,Jiwei Liu
Aman Wang
Cardio-oncology is an emerging interdisciplinary field focused on the intersection of cancer and cardiovascular disease. With the rising incidence of both cancer and cardiovascular disease in China, establishing a strong cardio-oncology fra...
Reopening Pandora's box: is there a role for HDL in breast cancer? [0.03%]
开启潘多拉的盒子：高密度脂蛋白在乳腺癌中有作用吗？
Maria Isabela Alves Caldas Sawada,Monique de Fátima de Mello Santana,Milena Gomes Vancini et al.
Maria Isabela Alves Caldas Sawada et al.
Plasma lipid and lipoprotein profiles are recognized as key modulators in breast cancer (BC) development. Notably, the association between high-density lipoprotein cholesterol (HDLc) and BC remains controversial, with studies reporting posi...
Advances and mechanisms of gut microbiota modulation in enhancing immune checkpoint inhibitor efficacy [0.03%]
调节肠道菌群增强免疫检查点抑制剂疗效的进展与机制研究
Li Chen,Baoyi Li,Menghang Zu et al.
Li Chen et al.
The gut microbiota is crucial for maintaining human health by regulating immune homeostasis and metabolic function. Immune checkpoint inhibitors (ICIs) have emerged as a cornerstone of cancer immunotherapy, yet their effectiveness is often ...