Microbial Metabolites for Cancer Immunotherapy: Current Evidence and Future Directions [0.03%]
微生物代谢产物在癌症免疫治疗中的作用：现有证据及未来发展方向
Xin-Xin Wang,Jia-Jie Liang,Xu Duan et al.
Xin-Xin Wang et al.
Immune checkpoint blockade (ICB) therapy has transformed cancer treatment by activating the body's immune defenses to combat malignancies, offering substantial therapeutic outcomes for patients with advanced cancers. However, its efficacy v...
Microbial Modulation as a Game Changer: Boosting Immunotherapy Efficacy in Breast Cancer [0.03%]
微生物调控作为游戏规则改变者：提高乳腺癌免疫治疗效力
Fada Xia,Qiaoli Yi,Zhijie Xu et al.
Fada Xia et al.
Breast cancer is generally regarded as an immunologically cold tumor, characterized by limited T cell infiltration and poor responsiveness to immune checkpoint inhibitors. Increasing evidence suggests that the human microbiome, including bo...
From the gut to disease: Microbiota-derived short chain fatty acids and their precursors lactate and succinate in atherosclerosis and cancer [0.03%]
从肠道到疾病：短链脂肪酸及其前体乳酸和琥珀酸在动脉粥样硬化和癌症中的作用
Lídia Cedó,Ana Madeira,Pau Caro
Lídia Cedó
Atherosclerosis and cancer are two of the most prevalent chronic diseases worldwide, representing leading causes of morbidity and mortality. These conditions share overlapping risk factors and pathophysiological mechanisms, including persis...
Cracking the Resistance Code:The Molecular Reclassification of Cancer and Precision Therapy Strategies [0.03%]
破解耐药性密码：癌症分子再分类和精准治疗策略
Mina Nikanjam,Razelle Kurzrock
Mina Nikanjam
The molecular reclassification of cancer has enabled a therapeutic revolution. We now know that metastatic cancers have heterogenous molecular landscapes, which can differ within and between histologies, and may also vary between tumor site...
Yuki Kuranaga,Yasmin Hatem,Hans E Grossniklaus et al.
Yuki Kuranaga et al.
Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults, presenting significant clinical challenges due to its aggressive nature and metastatic potential, which results in poor prognosis in some patients. Despite rec...
Clonal evolution and therapy resistance in the era of precision cancer medicine Evolutionary trajectories in pediatric cancer [0.03%]
精确癌症医学时代的克隆演化和治疗抵抗以及儿童肿瘤的进化轨迹
Jenny Karlsson,Mayen Briggs,Aditi Vedi et al.
Jenny Karlsson et al.
Pediatric cancers exhibit complex evolutionary dynamics driven by genetic instability, clonal selection, epigenetic reprogramming, and microenvironmental interactions. Tumor evolution is typically characterized by branching phylogenies, whe...
The complex interplay of lipoprotein(a) and cancer in the era of emerging therapeutics [0.03%]
新兴疗法时代的脂蛋白(a)与癌症的复杂相互作用
Vanessa Bianconi,Massimo R Mannarino,Filippo Figorilli et al.
Vanessa Bianconi et al.
In the last decades, the biological properties of Lp(a) have attracted increasing attention for their possible involvement in a wide range of clinical conditions other than atherosclerotic cardiovascular disease. To date, whether a pathogen...
M C Martinez-Campanario,Marlies Cortés,Lu Han et al.
M C Martinez-Campanario et al.
This review explores the dual roles of lipid-laden macrophages (LL-Macs) in inflammation, atherosclerosis and cancer, emphasizing both their shared and divergent functions across physiological and pathological conditions. Lipid metabolism r...
Molecular mechanisms and therapies of immune checkpoint inhibitor associated myocarditis: update on recent developments [0.03%]
免疫检查点抑制剂相关心肌炎的分子机制和治疗：近期研究进展更新
Jiaqi Li,Lin Chen,Xiaolin Liu et al.
Jiaqi Li et al.
Immune checkpoint inhibitors (ICIs) enhance systemic antitumor immune responses by improving the ability of immune cells to recognize and kill tumor cells specifically. Activated T lymphocytes may target tissues and organs outside the tumor...
Impaired Cholesterol and LDL Uptake Pathways in the Development of Oncological and Cardiovascular Diseases [0.03%]
胆固醇和低密度脂蛋白摄取途径异常在肿瘤和心血管疾病发生中的作用
A Solanelles Curco,E Garcia,A Polishchuk et al.
A Solanelles Curco et al.
Dietary lipids play a critical role in the development of cardiovascular disease and cancer by influencing key cellular processes. Lipoprotein and fatty acid receptors activate intracellular signaling pathways that promote tumor growth and ...