M C Martinez-Campanario,Marlies Cortés,Lu Han et al.
M C Martinez-Campanario et al.
This review explores the dual roles of lipid-laden macrophages (LL-Macs) in inflammation, atherosclerosis and cancer, emphasizing both their shared and divergent functions across physiological and pathological conditions. Lipid metabolism r...
Molecular mechanisms and therapies of immune checkpoint inhibitor associated myocarditis: update on recent developments [0.03%]
免疫检查点抑制剂相关心肌炎的分子机制和治疗：近期研究进展更新
Jiaqi Li,Lin Chen,Xiaolin Liu et al.
Jiaqi Li et al.
Immune checkpoint inhibitors (ICIs) enhance systemic antitumor immune responses by improving the ability of immune cells to recognize and kill tumor cells specifically. Activated T lymphocytes may target tissues and organs outside the tumor...
Impaired Cholesterol and LDL Uptake Pathways in the Development of Oncological and Cardiovascular Diseases [0.03%]
胆固醇和低密度脂蛋白摄取途径异常在肿瘤和心血管疾病发生中的作用
A Solanelles Curco,E Garcia,A Polishchuk et al.
A Solanelles Curco et al.
Dietary lipids play a critical role in the development of cardiovascular disease and cancer by influencing key cellular processes. Lipoprotein and fatty acid receptors activate intracellular signaling pathways that promote tumor growth and ...
Hao Li,Fei-Yang Chen,Qing Wang et al.
Hao Li et al.
Tertiary lymphoid structures (TLSs) are essential in cancer immunotherapy, markedly improving the efficacy of immune checkpoint blockade (ICB) therapy. The presence of TLSs within the tumor microenvironment (TME) is associated with improved...
Extracellular Vesicles and the lipid messengers: The adipose tissue connection to cancer and metabolic disease [0.03%]
细胞外囊泡和脂质信使：脂肪组织与癌症及代谢性疾病的关系
Belen Picatoste,Heidy M Guaman,Marina Herrero-Matesanz et al.
Belen Picatoste et al.
Adipose tissue is essential for maintaining metabolic balance by serving as a major lipid depot for energy storage and release, while also secreting adipokines and extracellular vesicles that regulate inflammation and insulin sensitivity. T...
Maria J Monte,Laura Fàbrega,Marta R Romero et al.
Maria J Monte et al.
Bile acids (BAs) are cholesterol-derived metabolites synthesized by hepatocytes and secreted in bile to follow an inter-organ transit to the intestine, where they facilitate fat digestion and the absorption of lipids and liposoluble vitamin...
Ales Langer,Pavel Soucek,Veronika Vymetalkova et al.
Ales Langer et al.
FOLFIRINOX and gemcitabine plus nab-paclitaxel represent the most effective chemotherapy regimens for metastatic pancreatic cancer patients nowadays, but the median overall survival remains less than one year. Pharmacogenomics and the indiv...
Giuseppe Annunziata,Massimiliano Caprio,Evelyn Frias-Toral et al.
Giuseppe Annunziata et al.
Among the various types of tumors, breast cancer (BC) has a high distribution in the world population and is responsible for a high mortality rate. Like other forms of cancer, BC is characterised by distinctive features such as high-energy ...
Microbiome unlocks cancer immunotherapeutic potential: State of the art and future [0.03%]
微生物组解锁癌症免疫治疗潜力：现状与未来方向
Han-Yue Luo,Lei-Ming Cao,Kan Zhou et al.
Han-Yue Luo et al.
Immunotherapy has overturned the traditional perception of cancer treatment and brought new vitality to the field of oncology, but it still has unresolved problems such as a low response rate and severe side effects. The microbiome has been...
The Impact of Obesity and Lipids on Cancer: Insights into Mechanisms and Potential Interventions [0.03%]
肥胖和脂质对癌症的影响：机制及潜在干预措施的启示
Montserrat Romero,Yi-Fan Lian,Albert Piquer et al.
Montserrat Romero et al.
Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes, are closely linked to different types of cancers. With obesity rates rising globally, its influence on cancer incidence and progression has become increasingly ...