Lipid metabolism in cancer is regulated by the integrated natural product-miRNA-target axis [0.03%]
整合天然产物-微小核糖核酸-靶基因轴调节癌症中的脂质代谢
Ya-Ting Chuang,Ching-Yu Yen,Yi-Hong Tsai et al.
Ya-Ting Chuang et al.
Signaling lipids have been shown to play multifaceted roles ranging from cell proliferation, metabolism, invasion, migration, and apoptosis. Mechanistically, these enzymes and their downstream targets constitute complicated and intertwined ...
Microbiota metabolism and immune regulation: From mechanisms to immunotherapeutic applications in cancer [0.03%]
微生物代谢与免疫调控：从机制到癌症免疫治疗应用
Sichen Yuan,Alexa Bremmer,Xicheng Yang et al.
Sichen Yuan et al.
The human microbiome plays a pivotal role in shaping immune responses by producing bioactive metabolites such as bile acids (BAs) and short-chain fatty acids (SCFAs). These microbial metabolites influence a broad range of cell types, includ...
Meilin Ye,Houyu Ju,Guoxin Ren et al.
Meilin Ye et al.
The intricate interplay between the gut microbiome and the host immune system has been recognized as a pivotal determinant of clinical outcomes in cancer immunotherapy. Mounting evidence suggests that specific microbial communities are asso...
Microbial Metabolites for Cancer Immunotherapy: Current Evidence and Future Directions [0.03%]
微生物代谢产物在癌症免疫治疗中的作用：现有证据及未来发展方向
Xin-Xin Wang,Jia-Jie Liang,Xu Duan et al.
Xin-Xin Wang et al.
Immune checkpoint blockade (ICB) therapy has transformed cancer treatment by activating the body's immune defenses to combat malignancies, offering substantial therapeutic outcomes for patients with advanced cancers. However, its efficacy v...
Microbial Modulation as a Game Changer: Boosting Immunotherapy Efficacy in Breast Cancer [0.03%]
微生物调控作为游戏规则改变者：提高乳腺癌免疫治疗效力
Fada Xia,Qiaoli Yi,Zhijie Xu et al.
Fada Xia et al.
Breast cancer is generally regarded as an immunologically cold tumor, characterized by limited T cell infiltration and poor responsiveness to immune checkpoint inhibitors. Increasing evidence suggests that the human microbiome, including bo...
From the gut to disease: Microbiota-derived short chain fatty acids and their precursors lactate and succinate in atherosclerosis and cancer [0.03%]
从肠道到疾病：短链脂肪酸及其前体乳酸和琥珀酸在动脉粥样硬化和癌症中的作用
Lídia Cedó,Ana Madeira,Pau Caro
Lídia Cedó
Atherosclerosis and cancer are two of the most prevalent chronic diseases worldwide, representing leading causes of morbidity and mortality. These conditions share overlapping risk factors and pathophysiological mechanisms, including persis...
Cracking the Resistance Code:The Molecular Reclassification of Cancer and Precision Therapy Strategies [0.03%]
破解耐药性密码：癌症分子再分类和精准治疗策略
Mina Nikanjam,Razelle Kurzrock
Mina Nikanjam
The molecular reclassification of cancer has enabled a therapeutic revolution. We now know that metastatic cancers have heterogenous molecular landscapes, which can differ within and between histologies, and may also vary between tumor site...
Yuki Kuranaga,Yasmin Hatem,Hans E Grossniklaus et al.
Yuki Kuranaga et al.
Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults, presenting significant clinical challenges due to its aggressive nature and metastatic potential, which results in poor prognosis in some patients. Despite rec...
Clonal evolution and therapy resistance in the era of precision cancer medicine Evolutionary trajectories in pediatric cancer [0.03%]
精确癌症医学时代的克隆演化和治疗抵抗以及儿童肿瘤的进化轨迹
Jenny Karlsson,Mayen Briggs,Aditi Vedi et al.
Jenny Karlsson et al.
Pediatric cancers exhibit complex evolutionary dynamics driven by genetic instability, clonal selection, epigenetic reprogramming, and microenvironmental interactions. Tumor evolution is typically characterized by branching phylogenies, whe...
The complex interplay of lipoprotein(a) and cancer in the era of emerging therapeutics [0.03%]
新兴疗法时代的脂蛋白(a)与癌症的复杂相互作用
Vanessa Bianconi,Massimo R Mannarino,Filippo Figorilli et al.
Vanessa Bianconi et al.
In the last decades, the biological properties of Lp(a) have attracted increasing attention for their possible involvement in a wide range of clinical conditions other than atherosclerotic cardiovascular disease. To date, whether a pathogen...