Microbiota and Cancer Immunotherapy: Mechanisms, Clinical Implications, and Precision Therapeutics [0.03%]
微生物群和癌症免疫治疗：机制、临床意义及精准治疗策略
Dongliang Wei,Yilan Sun,Jing Han et al.
Dongliang Wei et al.
The microbiome has emerged as a pivotal modulator of cancer immunotherapy, offering novel insights into the efficacy and toxicity of immune checkpoint inhibitors (ICIs). Recent evidence highlights that microbial communities and their metabo...
Lipid metabolism in cancer is regulated by the integrated natural product-miRNA-target axis [0.03%]
整合天然产物-微小核糖核酸-靶基因轴调节癌症中的脂质代谢
Ya-Ting Chuang,Ching-Yu Yen,Yi-Hong Tsai et al.
Ya-Ting Chuang et al.
Signaling lipids have been shown to play multifaceted roles ranging from cell proliferation, metabolism, invasion, migration, and apoptosis. Mechanistically, these enzymes and their downstream targets constitute complicated and intertwined ...
Microbiota metabolism and immune regulation: From mechanisms to immunotherapeutic applications in cancer [0.03%]
微生物代谢与免疫调控：从机制到癌症免疫治疗应用
Sichen Yuan,Alexa Bremmer,Xicheng Yang et al.
Sichen Yuan et al.
The human microbiome plays a pivotal role in shaping immune responses by producing bioactive metabolites such as bile acids (BAs) and short-chain fatty acids (SCFAs). These microbial metabolites influence a broad range of cell types, includ...
Meilin Ye,Houyu Ju,Guoxin Ren et al.
Meilin Ye et al.
The intricate interplay between the gut microbiome and the host immune system has been recognized as a pivotal determinant of clinical outcomes in cancer immunotherapy. Mounting evidence suggests that specific microbial communities are asso...