Lipid Dysregulation in Renal Cancer: Drivers of Tumor Growth and Determinants of Treatment-Induced Toxicity [0.03%]
脂质失调在肾癌中的作用：促进肿瘤生长和决定治疗诱导的毒性的因素
Mohammed Alnukhali,Alessia Fornoni,Alan Pollack et al.
Mohammed Alnukhali et al.
Background: Clear cell renal cell carcinoma (ccRCC) exhibits a distinctive metabolic signature marked by the excessive buildup of cholesterol and neutral lipids. This phenotype stems largely from the loss of the von Hippe...
Spatial Multi-Omics in Precision Medicine: Integrating Biological Insights Through Multidisciplinary Collaboration [0.03%]
精准医学中的空间多组学：通过跨学科合作整合生物学见解
Da Yeon Kim,Jeeyong Lee,Jiwon Choi et al.
Da Yeon Kim et al.
Spatial multi-omics has emerged as a transformative approach in biomedical research, enabling the integration of diverse molecular modalities while preserving their native spatial contexts. This review provides an overview of spatial multi-...
Hiroyuki Inuzuka,Wenyi Wei
Hiroyuki Inuzuka
Celestina Agyemang-Dua,Charles S Chung,Cristina Espinosa-Diez
Celestina Agyemang-Dua
Cancer therapies save lives but often "break hearts" by damaging the cardiovascular system. As survival improves, therapy-induced cardiotoxicity has become a defining challenge of modern oncology. Recent discoveries reveal that long non-cod...
Immune checkpoint inhibitor-induced myocarditis: focus on the downstream pathogenic components and potential therapeutics [0.03%]
免疫检查点抑制剂诱导的心肌炎：下游病原成分及潜在治疗方法:focus on the downstream pathogenic components and potential therapeutics
Yifan Chen,Xuejun Wang,Yihui Shen et al.
Yifan Chen et al.
Advent of immune checkpoint inhibitors (ICIs) has renovated onco-immunotherapy, with around 50% of cancer patients suitable for the treatment. However, patients treated by ICIs are in jeopardy for immune-related adverse events (irAEs) that ...
M Boschetti,I Hasballa,I Patelli et al.
M Boschetti et al.
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) comprise a heterogeneous group of tumors differing according to the primary lesion site, histological features, clinical status and prognosis. The etiopathogenesis of GEP-NEN is not ...
Protein lactylation in cancer and other pathologies: Epigenetic regulation of glycolysis and its therapeutic perspectives [0.03%]
蛋白质乳酰化在癌症及其他疾病中的作用：糖酵解的表观遗传调控及其治疗前景
Yaowen Zhang,Jianxiang Wang,Cong Li et al.
Yaowen Zhang et al.
Lactylation, a recently recognized post-translational protein modification, is reshaping research in epigenetics and molecular medicine. Emerging evidence indicates that lactylation plays a critical role in the onset and progression of canc...
Jie Xu,Linlin Guo,Yi Wang et al.
Jie Xu et al.
Abnormal metabolism is a typical characteristic of malignant tumors, broadly influencing the outcome of cancer therapy. Research on tumor metabolism is increasing exponentially in last decades. There is an urgent need to provide a blueprint...