Cell competition in tumor evolution and heterogeneity: Merging past and present [0.03%]
细胞竞争在肿瘤进化和异质性中的作用：过去与现在的融合
Christopher J Pelham,Masaki Nagane,Esha Madan
Christopher J Pelham
In many cases, cancers are difficult to eliminate because they develop resistance to a primary chemotherapy or targeted therapy. Tumors grow into diverse cell subpopulations, increasing the ability to resist elimination. The phenomenon of '...
Ali S Alzahrani
Ali S Alzahrani
Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway is one of the major cellular signaling pathways that plays an important role in basic intracellular functions. The PI3K/Akt/mTOR pathway regulat...
Maeve Long,Thomas G McWilliams
Maeve Long
Autophagy refers to an essential mechanism that evolved to sustain eukaryotic homeostasis and metabolism during instances of nutrient deprivation. During autophagy, intracellular cargo is encapsulated and delivered to the lysosome for elimi...
Ilaria Caon,Barbara Bartolini,Arianna Parnigoni et al.
Ilaria Caon et al.
Extracellular matrix (ECM) is a complex network of macromolecules such as proteoglycans (PGs), glycosaminoglycans (GAGs) and fibrous proteins present within all tissues and organs. The main role of ECM is not only to provide an essential me...
Estrogen receptor-mediated targeting of the extracellular matrix network in cancer [0.03%]
雌激素受体介导的癌症中细胞外基质网络靶向作用
Zoi Piperigkou,Nikos K Karamanos
Zoi Piperigkou
The biological functions of estrogens are regulated by estrogen receptors (ERα and ERβ), which contribute in the progression of several hormone-responsive cancer types via estrogen signaling mechanisms. The coordinated actions of ERs and ...
Nobuyuki Tanimura,Yasuyuki Fujita
Nobuyuki Tanimura
Several lines of evidence indicate that cell competition can occur in mammals. In particular, at the initial stage of carcinogenesis, normal epithelial cells are able to recognize the neighboring transformed cells and actively eliminate the...
Balney Rajitha,Rama Rao Malla,Ramakrishna Vadde et al.
Balney Rajitha et al.
Female-specific cancers are the most common cancers in women worldwide. Early detection methods remain unavailable for most of these cancers, signifying that most of them are diagnosed at later stages. Furthermore, current treatment options...
The "-OMICS" facet of melanoma: Heterogeneity of genomic, proteomic and metabolomic biomarkers [0.03%]
黑色素瘤的“-组学”特点：基因组、蛋白质组和代谢组生物标志物的异质性
Douglas Donnelly rd,Phyu P Aung,George Jour
Douglas Donnelly rd
In the recent decade, cutting edge molecular and proteomic analysis platforms revolutionized biomarkers discovery in cancers. Melanoma is the prototype with over 51,100 biomarkers discovered and investigated thus far. These biomarkers inclu...
Transcription factors in SOX family: Potent regulators for cancer initiation and development in the human body [0.03%]
SOX家族的转录因子：人体癌症发生发展的强力调控因素
Prasann Kumar,Tapan Kumar Mistri
Prasann Kumar
Transcription factors (TFs) have a key role in controlling the gene regulatory network that sustains explicit cell states in humans. However, an uncontrolled regulation of these genes potentially results in a wide range of diseases, includi...
Tumorigenic functions of serglycin: Regulatory roles in epithelial to mesenchymal transition and oncogenic signaling [0.03%]
Serglycin促肿瘤功能及其在上皮间质转化和致癌信号转导中的调控作用
Dimitra Manou,Nikos K Karamanos,Achilleas D Theocharis
Dimitra Manou
Numerous studies point out serglycin as an important regulator of tumorigenesis in a variety of malignancies. Serglycin expression correlates with the aggressive phenotype of tumor cells and serves as a poor prognostic indicator for disease...