Recent insights into apoptosis and toxic autophagy: The roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic [0.03%]
近期关于凋亡和毒性自噬的最新认识：MDA-7/IL-24在多维度抗癌治疗中的作用
Luni Emdad,Praveen Bhoopathi,Sarmistha Talukdar et al.
Luni Emdad et al.
Apoptosis and autophagy play seminal roles in maintaining organ homeostasis. Apoptosis represents canonical type I programmed cell death. Autophagy is viewed as pro-survival, however, excessive autophagy can promote type II cell death. Defe...
Zhenxing Liang,Jing Xu,Chunhu Gu
Zhenxing Liang
The SRY-related high-mobility-group box (Sox) gene family encodes a set of transcription factors and is defined by the presence of highly conserved domains. The Sox gene can be divided into 10 groups (A-J). The SoxD subpopulation consists o...
The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics [0.03%]
细胞自噬在线粒体质量控制中的作用及其在癌症和癌症治疗中的多面角色
Debasna P Panigrahi,Prakash P Praharaj,Chandra S Bhol et al.
Debasna P Panigrahi et al.
Mitophagy is an evolutionarily conserved cellular process which selectively eliminates dysfunctional mitochondria by targeting them to the autophagosome for degradation. Dysregulated mitophagy results in the accumulation of damaged mitochon...
Antiphospholipid antibodies and antiphospholipid syndrome in cancer: Uninvited guests in troubled times [0.03%]
抗磷脂抗体和癌症抗磷脂综合征：不安稳时期的不速之客
Md Asiful Islam
Md Asiful Islam
Antiphospholipid antibodies (aPLs) are autoantibodies with laboratory significance in developing thrombosis and pregnancy morbidity in antiphospholipid syndrome (APS). High prevalence of aPLs namely - anticardiolipin, anti-β2-glycoprotein ...
Role of heparanase in tumor progression: Molecular aspects and therapeutic options [0.03%]
肝胰酶在肿瘤进展中的作用：分子方面和治疗选择
Valentina Masola,Gianluigi Zaza,Giovanni Gambaro et al.
Valentina Masola et al.
Heparanase (HPSE) is an endoglycosidase that catalyses the cutting of the side chains of heparan-sulphate proteoglycans (HS), thus determining the remodelling of the extracellular matrix and basement membranes, as well as promoting the rele...
Nancy A Espinoza-Sánchez,Martin Götte
Nancy A Espinoza-Sánchez
Over the past few decades, understanding how tumor cells evade the immune system and their communication with their tumor microenvironment, has been the subject of intense investigation, with the aim of developing new cancer immunotherapies...
Autoimmunity, checkpoint inhibitor therapy and immune-related adverse events: A review [0.03%]
自身免疫、检查点抑制剂治疗及免疫相关不良事件：综述论文
Shaheen Khan,David E Gerber
Shaheen Khan
Immune checkpoint inhibitors have emerged as a remarkable treatment option for diverse cancer types. However, a significant number of patients on checkpoint inhibitors develop immune-related adverse events (irAEs) affecting a wide variety o...
Cell competition in tumor evolution and heterogeneity: Merging past and present [0.03%]
细胞竞争在肿瘤进化和异质性中的作用：过去与现在的融合
Christopher J Pelham,Masaki Nagane,Esha Madan
Christopher J Pelham
In many cases, cancers are difficult to eliminate because they develop resistance to a primary chemotherapy or targeted therapy. Tumors grow into diverse cell subpopulations, increasing the ability to resist elimination. The phenomenon of '...
Ali S Alzahrani
Ali S Alzahrani
Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway is one of the major cellular signaling pathways that plays an important role in basic intracellular functions. The PI3K/Akt/mTOR pathway regulat...
Maeve Long,Thomas G McWilliams
Maeve Long
Autophagy refers to an essential mechanism that evolved to sustain eukaryotic homeostasis and metabolism during instances of nutrient deprivation. During autophagy, intracellular cargo is encapsulated and delivered to the lysosome for elimi...