T-Cell Senescence: Unlocking the Tumor Immune "Dark Box" - A Multidimensional Analysis from Mechanism to Tumor Immunotherapeutic Intervention [0.03%]
T细胞衰老：解锁肿瘤免疫“暗箱”——从机制到肿瘤免疫干预的多维度分析
Jia Cheng,Jian Zheng,Chen Ma et al.
Jia Cheng et al.
Immunosenescence is the dysfunction of the immune system that occurs with age, a process that is complex and characterized by several features, of which T-cell senescence is one of the key manifestations. In the tumor microenvironment, sene...
Genomic instability, DNA damage response and telomere homeostasis in pancreatic cancer [0.03%]
胰腺癌的基因组不稳定、DNA损伤反应及端粒动态平衡
Saba Selvi,Carmen Macías Real,Manuel Gentiluomo et al.
Saba Selvi et al.
Pancreatic cancer (PC) is becoming one of the most serious health problems at present, but its causes and risk factors are still unclear. One of the drivers in pancreatic carcinogenesis is altered genomic (DNA) integrity with subsequent gen...
The potential application of stroma modulation in targeting tumor cells: focus on pancreatic cancer and breast cancer models [0.03%]
肿瘤间质调控在肿瘤细胞靶向治疗中的潜在应用：重点研究胰腺癌和乳腺癌模型
Giuseppina Roscigno,Sacha Jacobs,Belen Toledo et al.
Giuseppina Roscigno et al.
The tumor microenvironment (TME) plays a crucial role in cancer development and spreading being considered as "the dark side of the tumor". Within this term tumor cells, immune components, supporting cells, extracellular matrix and a myriad...
The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC [0.03%]
暴露组学与胰腺癌、PDAC的生活方式及环境风险因素
Giulia Peduzzi,Livia Archibugi,Riccardo Farinella et al.
Giulia Peduzzi et al.
Pancreatic cancer (PC), particularly pancreatic ductal adenocarcinoma (PDAC), is a significant global health issue with high mortality rates. PDAC, though only 3% of cancer diagnoses, causes 7% of cancer deaths due to its severity and asymp...
HDAC inhibitors: Cardiotoxicity and paradoxical cardioprotective effect in ischemia-reperfusion myocardiocyte injury [0.03%]
组蛋白去乙酰化酶抑制剂与缺血/再灌注损伤心肌细胞的护心和伤心作用
Kenneth K W To,Seda Tolu,Longling Wang et al.
Kenneth K W To et al.
Histone deacetylase inhibitors (HDACIs) are epigenetic drugs that regulate the acetylation status of histones and non-histone proteins, thereby leading to chromatin remodeling and transcriptional regulation of key apoptotic and cell cycle r...
Metabolic Reprogramming in Cancer Therapy-Related Cardiovascular Toxicity: Mechanisms and Intervention Strategies [0.03%]
癌症治疗相关心血管毒性的代谢重构：机制和干预策略
Cheng Zeng,Ying Gao,Bo Lan et al.
Cheng Zeng et al.
Cancer therapy-related cardiovascular toxicity (CTR-CVT) poses a major challenge in managing cancer patients, contributing significantly to morbidity and mortality among survivors. CTR-CVT includes various cardiovascular issues, such as car...
Yinglin Huang,Yuhong Zhan,Yuhua Zhan
Yinglin Huang
Diagnosis and treatment of cancer constitute a deeply stressful experience that involves unique and common problems and generates uncertainty, fear and emotional distress. Furthermore, there are reciprocal interactions between psychological...
Qiufen Bi,Junzhang Zhao,Jun Nie et al.
Qiufen Bi et al.
Metabolic reprogramming is pivotal in malignant transformation and cancer progression. Tumor metabolism is shaped by a complex interplay of both intrinsic and extrinsic factors that are not yet fully elucidated. It is of great value to unra...
Mechanisms and Applications of Apolipoproteins and Apolipoprotein Mimetic Peptides: Common Pathways in Cardiovascular Disease and Cancer [0.03%]
脂蛋白和脂蛋白模拟肽的作用机制及应用：心血管疾病与癌症的共同通路
Samuel C Delk,Faheem W Gurgis,Srinivasa T Reddy
Samuel C Delk
Apolipoproteins are the defining functional component of lipoproteins and play critical roles in lipid transport and metabolism. High-density lipoprotein (HDL) and its primary functional constituent, apolipoprotein A-I, are of particular im...
Targeting pancreatic cancer screening by identification of pathogenic variants of BRCA2/ BRCA1 in healthy individuals who have no known family history of pancreatic cancer: The arguments for and against [0.03%]
在无胰腺癌家族史的健康人中鉴定出有害的BRCA2 / BRCA1变异以进行胰腺癌筛查：支持和反对的理由
Julie Earl,Agapi Kataki,Federico Canzian et al.
Julie Earl et al.
The majority of patients with pancreatic ductal adenocarcinoma (PDAC) are no longer suitable for treatment with curable intent at the time of diagnosis resulting in a 5-year survival of less than 10%. Imaging of asymptomatic individuals cou...