Qiufen Bi,Junzhang Zhao,Jun Nie et al.
Qiufen Bi et al.
Metabolic reprogramming is pivotal in malignant transformation and cancer progression. Tumor metabolism is shaped by a complex interplay of both intrinsic and extrinsic factors that are not yet fully elucidated. It is of great value to unra...
Mechanisms and Applications of Apolipoproteins and Apolipoprotein Mimetic Peptides: Common Pathways in Cardiovascular Disease and Cancer [0.03%]
脂蛋白和脂蛋白模拟肽的作用机制及应用：心血管疾病与癌症的共同通路
Samuel C Delk,Faheem W Gurgis,Srinivasa T Reddy
Samuel C Delk
Apolipoproteins are the defining functional component of lipoproteins and play critical roles in lipid transport and metabolism. High-density lipoprotein (HDL) and its primary functional constituent, apolipoprotein A-I, are of particular im...
Targeting pancreatic cancer screening by identification of pathogenic variants of BRCA2/ BRCA1 in healthy individuals who have no known family history of pancreatic cancer: The arguments for and against [0.03%]
在无胰腺癌家族史的健康人中鉴定出有害的BRCA2 / BRCA1变异以进行胰腺癌筛查：支持和反对的理由
Julie Earl,Agapi Kataki,Federico Canzian et al.
Julie Earl et al.
The majority of patients with pancreatic ductal adenocarcinoma (PDAC) are no longer suitable for treatment with curable intent at the time of diagnosis resulting in a 5-year survival of less than 10%. Imaging of asymptomatic individuals cou...
Impact of tumor metabolism on tumor progression and therapy Cathepsins: emerging targets in the tumor ecosystem to overcome cancers [0.03%]
肿瘤代谢对肿瘤进展和治疗的影响； cathezins：肿瘤生态系统中克服癌症的新兴目标
Yuki Fujii,Zahra Asadi,Kamiya Mehla
Yuki Fujii
Cathepsins, a group of lysosomal peptidases, have traditionally been recognized as tumor facilitators. Recent research, however, highlights their critical role in orchestrating cancer and the tumor microenvironment (TME). Primality, catheps...
Pierrick Martinez,William B Grant
Pierrick Martinez
Obesity is an important risk factor for incidence and death for many types of cancer. Vitamin D reduces risk of incidence and death for many types of cancer. This review outlines the mechanisms by which obesity increases risk of cancer, how...
Diversity of metabolic features and relevance to clinical subtypes of gliomas [0.03%]
胶质瘤代谢特征的多样性及其与临床亚型的相关性
Pushan Dasgupta,Vinay K Puduvalli
Pushan Dasgupta
Gliomas carry a dismal prognosis and have proven difficult to treat. Current treatments and efforts to target individual signaling pathways have failed. This is thought to be due to genetic and epigenetic heterogeneity and resistance. There...
PANCREATIC NEUROENDOCRINE NEOPLASMS (pNENs): GENETIC AND ENVIRONMENTAL BIOMARKERS FOR RISK OF OCCURRENCE AND PROGNOSIS [0.03%]
胰腺神经内分泌肿瘤(pNEN)：发生和预后风险的遗传和环境生物标志物
Matteo Tacelli,Manuel Gentiluomo,Paolo Biamonte et al.
Matteo Tacelli et al.
Pancreatic neuroendocrine neoplasms (pNENs) are rare and heterogeneous tumors arising from neuroendocrine cells, representing approximately 10% of all Gastro-Entero-Pancreatic neuroendocrine neoplasms. While most pNENs are sporadic, a subse...
Heng Wang,Fang Xu,Chao Wang
Heng Wang
The tumor microenvironment (TME) is a complex ecosystem that plays a crucial role in tumor progression and response to therapy. The metabolic characteristics of the TME are fundamental to its function, influencing not only cancer cell proli...
The Relationship of the Microbiome, Associated Metabolites and the Gut Barrier with Pancreatic Cancer [0.03%]
微生物群、相关代谢物和胃肠道屏障与胰腺癌的关系
Neil Daniel,Riccardo Farinella,Flavia Belluomini et al.
Neil Daniel et al.
Pancreatic cancers have high mortality and rising incidence rates which may be related to unhealthy western-type dietary and lifestyle patterns as well as increasing body weights and obesity rates. Recent data also suggest a role for the gu...
The Warburg effect: the hacked mitochondrial-nuclear communication in cancer [0.03%]
战争堡效应：癌症中被破坏的线粒体与细胞核通讯
Haowen Jiang,Jiangbin Ye
Haowen Jiang
Mitochondrial-nuclear communication is vital for maintaining cellular homeostasis. This communication begins with mitochondria sensing environmental cues and transmitting signals to the nucleus through the retrograde cascade, involving meta...