Simona Cernea,Dana Crişan,Cristina-Mihaela Lăcătuşu et al.
Simona Cernea et al.
Obesity and type 2 diabetes mellitus are increasingly recognized as important risk factors for cancer development and progression, including cancers of the digestive system. Indeed, epidemiologic evidence demonstrated that both conditions i...
The biology and evolution of Richter transformation in chronic lymphocytic leukemia [0.03%]
慢性淋巴细胞白血病中里希特转化的生物学和进化过程
Ferran Nadeu,Dimitar G Efremov
Ferran Nadeu
Richter transformation (RT) is a relatively rare but clinically challenging event in the natural history of chronic lymphocytic leukemia (CLL), characterized by the abrupt transformation of CLL into an aggressive lymphoma, most commonly dif...
Intratumor Heterogeneity and Clonal Evolution in Sarcomas: Molecular, Cellular, and Functional Drivers of Therapy Resistance [0.03%]
软组织肉瘤的肿瘤内异质性和克隆演化：治疗抵抗的分子、细胞和功能驱动因素
Thomas G P Grünewald,Ina Oehme,Johanna Wagner et al.
Thomas G P Grünewald et al.
Sarcomas, malignant neoplasms of mesenchymal origin, comprise more than 100 entities and numerous histologic subtypes. Their relative rarity compared with carcinomas, interpatient diversity, and pronounced intratumor heterogeneity (ITH) mak...
Maria Creignou,Martina Sarchi,Elsa Bernard et al.
Maria Creignou et al.
Myelodysplastic syndromes/neoplasms (MDS) are a heterogeneous group of myeloid malignancies characterized by clonality, cytopenia, bone marrow dysplasia, and a variable risk of progression to acute myeloid leukemia (AML). With few therapeut...
E Camajani,S Gorini,A Feraco et al.
E Camajani et al.
Cancer is a complex group of diseases characterized by the uncontrolled growth and spread of abnormal cells, and it remains a major global health concern. In order to meet the increased energy and biosynthetic requirements of rapid growth, ...
Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology [0.03%]
从心血管健康到抗肿瘤药物治疗：他汀类药物的潜在应用
Alaa Abdelhamid,Dima Nasrallah,Esraa Ahmed et al.
Alaa Abdelhamid et al.
Statins, traditionally used for managing hypercholesterolemia, have emerged as promising agents for cancer therapy. By targeting the mevalonate pathway-a cornerstone of cellular metabolism and tumorigenesis-statins disrupt critical processe...
Cancer therapy-related cardiovascular toxicity: Current progress and future perspectives [0.03%]
癌症治疗相关心血管毒性：当前进展与未来展望
Hongcai Shang,William Cho,Yanwei Xing
Hongcai Shang
Microbiome-modulated immunotherapy in oncology: Current applications and future prospects [0.03%]
肿瘤学中的微生物组调节免疫疗法：当前应用和未来前景
Yu Liu,Keyan Miao,Xi Yang
Yu Liu
Cancer immunotherapy has transformed oncology, yet therapeutic efficacy remains heterogeneous and frequently limited by primary or acquired resistance. Increasing evidence demonstrates that both intra- and extratumoral microbiota critically...
Lipid metabolic alterations in cancer: common pathophysiology with cardiovascular disease [0.03%]
癌症中的脂质代谢改变：与心血管疾病的共同病理生理学
Maria Llena-Meler,Alberto Canfran-Duque,Julio Madrigal-Matute et al.
Maria Llena-Meler et al.
Obesity-induced chronic inflammation and lipid metabolic imbalance form a pivotal nexus linking cardiovascular disease and cancer. Dysfunctional adipose tissue establishes a pro-inflammatory environment through hypoxia-driven macrophage pol...
Integrative spatial omics and artificial intelligence: transforming cancer research with omics data and AI [0.03%]
整合型空间组学与人工智能：利用组学数据和AI变革癌症研究
Maddison McKenzie,Sergio Erdel Irac,Zhian Chen et al.
Maddison McKenzie et al.
The integration of multi-omics data, including genomics, transcriptomics, proteomics, epigenomics, and metabolomics, coupled with histological spatial data has transformed biomedical research, offering unprecedented insights into cellular f...