The trypanosome flagellum as model for parasitology, cell biology and ciliopathies [0.03%]
锥虫鞭毛作为寄生虫学、细胞生物学和纤毛病的模型
Amandine Hecquet,Serge Bonnefoy,Philippe Bastin
Amandine Hecquet
Cilia and flagella exhibit widely conserved structures and functions across species. In humans, defects in these organelles are responsible for diseases called ciliopathies and many model organisms are used to study them. In this review, we...
A metabolic view of gastrulation: Coordinating signalling, epigenetics and morphogenesis [0.03%]
代谢视角下的原肠运动：协调信号转导、表观遗传和形态建成
Tatiana Firfa,Tamara Civetta,Eunice HoYee Chan et al.
Tatiana Firfa et al.
Gastrulation is the morphogenetic process by which the single-layered pluripotent epiblast is reorganised into the three germ layers and the basic body plan is established. While the metabolic state of pluripotent stem cells is well charact...
Evgeniya V Shmeleva,Michael Levin
Evgeniya V Shmeleva
Biological systems maintain structure and function through hierarchical control, redundancy and surveillance across scales. These same features create leverage points for agents that establish a persistent presence in host systems, includin...
Nutrient-sensing pathways in adult stem cells: Orchestrating homeostasis, aging, and disease [0.03%]
成人干细胞中的营养感知途径：调控稳态、衰老和疾病
Tianxiong Xiao,Zhiyao Xie,Lijun Yao et al.
Tianxiong Xiao et al.
Nutrient-sensing pathways, including mTOR, AMPK, Sirtuins, and insulin/IGF-1 signaling, are central regulators orchestrating adult stem cell (ASC) fate by dynamically modulating cellular metabolism. This review proposes a framework that int...
Multiscale biophysical control of epithelial shape transitions during animal development [0.03%]
动物发育过程中上皮形状转换的多尺度生物物理调控
Jianyi Mai,Abhirami Anil Gayathry,David M Richards et al.
Jianyi Mai et al.
The regulation of epithelial cell shape is fundamental to development, homeostasis and disease, and is intricately linked to tissue function. Epithelial morphology emerges from integration of biochemical and mechanical cues across multiple ...
Si Li,Xiang Shi,Xue-Lian Sun et al.
Si Li et al.
Adult neural stem cells (NSCs) persist throughout life in discrete neurogenic niches of the mammalian brain, most prominently the subventricular zone (SVZ), the subgranular zone (SGZ) of the hippocampal dentate gyrus, and the hypothalamic v...
Lei Xia,Anish Ashok Adpaikar,Liling Wen et al.
Lei Xia et al.
Tissue development and regeneration are governed by a dynamic interplay between biochemical signaling programs and biophysical forces that act across molecular, cellular, and tissue scales. Mechanical cues including cytoskeletal tension, ex...
Cilia and flagella - Current insights from diverse experimental systems [0.03%]
纤毛和鞭毛——来自多种实验体系的最新认识
Junmin Pan
Junmin Pan
Editorial for special issue "When should mathematical models be used in biology" [0.03%]
特刊 “在生物学中何时应使用数学模型”的主编评论
Wallace F Marshall
Wallace F Marshall
Conserved machinery, divergent functions: evolutionary plasticity of the STK36/ULK4 kinase complex in ciliogenesis and signaling [0.03%]
保守的机械装置，发散的功能：STK36 / ULK4激酶复合物在纤毛发生和信号传导中的进化塑性
Bowen Wan,Ngai Yin Brad Leung,Mu He
Bowen Wan
The cilium is an ancient organelle in eukaryotes essential for motility, sensory perception, and signaling, and ciliary dysfunction underlies a spectrum of human ciliopathies. In this context, the STK36/ULK4 kinase complex has emerged as a ...