Tzu-Yi Huang,Steffen Lemke,Yu-Chiun Wang
Tzu-Yi Huang
Morphogenesis is the process in which cells, tissues, organs and embryos acquire orderedness, patterns, shapes and higher order organizations. Most morphogenetic processes are known to be controlled by genetic programs, and experimental and...
Intra- and inter-organ communications in aging and cancer: Local and global spatial perspectives [0.03%]
衰老和癌症的组织内外通信：局部和全局空间视角
Onkar Mulay,Aitor Benedicto,Yui Murata et al.
Onkar Mulay et al.
Interactions among neighbouring cells are fundamental to tissue function and can be specifically mapped using single-cell and spatial transcriptomics data. Overall, cell-cell interactions (CCIs) are essential for proper tissue function, inc...
Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms [0.03%]
动物中的上皮细胞可塑性：角色与机制的进化见解
Hiroki Nagai,Yu-Ichiro Nakajima
Hiroki Nagai
Epithelial tissues function as multicellular communities that preserve tissue integrity while adapting to diverse environmental stresses by altering cell behaviors. A striking manifestation of such adaptability is cell plasticity, the abili...
Machines all the way up and cognition all the way down: Updating the machine metaphor in biology [0.03%]
从上至下的机器模式和认知：生物学中的机器比喻更新
Michael Levin,Richard Watson
Michael Levin
Cell and developmental biology (CDB) offer numerous remarkable examples of collective adaptive plasticity, as cells coordinate to implement large-scale form and function. Despite the gaps in understanding, it is often assumed that the machi...
A cellular and molecular perspective on organotypic lymphatic (dys)function [0.03%]
从细胞和分子角度解析器官特异性淋巴管（功能障碍）的功能
Sanjay Sunil Kumar,Katharina Uphoff,Sophie Hötte et al.
Sanjay Sunil Kumar et al.
The lymphatic vascular system maintains fluid homeostasis, allows uptake of dietary lipids, and serves as a conduit for immune cell trafficking. Functional aspects of the lymphatic vasculature are governed by specific features of lymphatic ...
Marga Albu,David Sedmera,Didier Y R Stainier
Marga Albu
The sinus node, at the venous end of the heart, automatically generates the electrical impulses that initiate each heart beat and set the heart's rhythm. From the sinus node, these action potentials are transmitted by specialized structures...
Matthias Függer,Thomas Nowak,Kerian Thuillier
Matthias Függer
Biological systems are mastering the art of composing cells into colonies, tissues, and organisms. This article reviews striking similarities and differences between such biological systems and distributed computing systems, where computati...
Mie Wong,Tetsuya Hiraiwa
Mie Wong
David I Kaplan,Xiang Guo,Sasuni D Hirimuthugoda et al.
David I Kaplan et al.
Spatial transcriptomics (ST) has emerged as a powerful tool in cancer research, significantly expanding our capacity to study the complexity of tumour ecosystems. Together with the diversity of ST platforms, a plethora of analysis approache...
How growth-induced stresses guide shape changes during animal morphogenesis: Mechanisms and implications [0.03%]
生长引发的应力在动物形态发生过程中指导形状变化的机制及意义
A Erlich,S Harmansa
A Erlich
Morphogenesis, the process by which an organism develops its shape, is orchestrated by a complex interplay of genetic, biochemical, and mechanical factors. While myosin-driven contractility has been widely acknowledged as a critical driver ...