The tissue glycome as regulator of immune activation and tolerance mediated by C-type lectins and Siglecs [0.03%]
C型凝集素和Siglec通过调控组织糖组调节免疫激活与耐受性
Eleonora Nardini,Ernesto Rodriguez,Yvette van Kooyk
Eleonora Nardini
The immune system is a complex network of highly specialized microenvironments, denominated niches, which arise from dynamic interactions between immune and parenchymal cells as well as acellular components such as structural elements and l...
Galectins and Host-Pathogen Interactions: The roles in viral infections [0.03%]
念珠菌与宿主病原相互作用：病毒感染中的作用
Sheng-Fang Wang,Hung-Lin Chen,Fu-Tong Liu
Sheng-Fang Wang
Galectins, a family of carbohydrate-binding proteins, play crucial roles in the host-virus interaction landscape. This review explores the multifaceted contributions of endogenous galectins to various stages of the viral lifecycle, includin...
Guijun Liu,Xuxiao He,Gaoxiang Zhao et al.
Guijun Liu et al.
The complement system plays crucial roles in both innate and adaptive immune responses, facilitating the elimination of pathogens such as microorganisms and damaged cells, including cancer cells. It is tightly regulated and integrated with ...
NGS data analysis for molecular diagnosis of Inborn Errors of Immunity [0.03%]
高通量测序数据分析在先天性免疫缺陷病分子诊断中的应用
X T Yang,W L Yang,Y L Lau
X T Yang
Inborn errors of immunity (IEI) encompass a group of disorders with a strong genetic component. Prompt and accurate diagnosis of these disorders is essential for effective clinical management. Next-generation sequencing (NGS) has significan...
The role of sialoglycans in modulating dendritic cell function and tumour immunity [0.03%]
唾液酸糖蛋白调节树突细胞功能和肿瘤免疫的作用机制研究
Zélia Silva,Cátia O Soares,Mariana Barbosa et al.
Zélia Silva et al.
Dendritic cells (DCs) are crucial for initiating immune responses against tumours by presenting antigens to T cells. Glycosylation, particularly sialylation, plays a significant role in regulating cell functions, by modulating protein foldi...
Sialic acid and Siglec receptors in tumor immunity and immunotherapy [0.03%]
唾液酸和Siglec受体在肿瘤免疫和免疫治疗中的作用
Natalia Rodrigues Mantuano,Heinz Läubli
Natalia Rodrigues Mantuano
Immunotherapy, including immune checkpoint inhibition, has transformed cancer therapy in recent years, providing new and potentially curative options for patients with even advanced disease. However, only a minority of patients achieve long...
Shaping hematopoietic cell ecosystems through galectin-glycan interactions [0.03%]
通过半乳糖凝集素-聚糖相互作用塑造造血细胞生态系统
Mirta Schattner,Bethan Psaila,Gabriel A Rabinovich
Mirta Schattner
Hematopoiesis- the formation of blood cell components- continually replenishes the blood system during embryonic development and postnatal lifespans. This coordinated process requires the synchronized action of a broad range of cell surface...
ABO blood groups and galectins: Implications in transfusion medicine and innate immunity [0.03%]
ABO血型和半乳糖凝集素：输血医学和先天性免疫中的意义
Connie M Arthur,Marie Hollenhorst,Shang-Chuen Wu et al.
Connie M Arthur et al.
ABO blood group antigens, which are complex carbohydrate moieties, and the first human polymorphisms identified, are critical in transfusion medicine and transplantation. Despite their discovery over a century ago, significant questions rem...
The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system [0.03%]
糖链在健康和疾病中的作用：肠道微生物群与宿主免疫系统相互作用的调节因子
Lucy I Crouch,Cláudia S Rodrigues,Cassie R Bakshani et al.
Lucy I Crouch et al.
The human gut microbiota is home to a diverse collection of microorganisms that has co-evolved with the host immune system in which host-microbiota interactions are essential to preserve health and homeostasis. Evidence suggests that the pe...
High-throughput N-glycan analysis in aging and inflammaging: State of the art and future directions [0.03%]
高通量N-聚糖分析在衰老和发炎老化中的研究现状及未来方向
A Cindrić,T Pribić,G Lauc
A Cindrić
As the global population ages at an unprecedented rate, the prevalence of age-related diseases is increasing, making inflammaging - a phenomenon characterized by a chronic, low-grade inflammatory state that follows aging - a significant con...