Complement regulators as novel targets for anti-cancer therapy: A comprehensive review [0.03%]
补体调节因子作为抗癌症治疗的新靶点：全面综述
Ruchi Saxena,Elizabeth B Gottlin,Michael J Campa et al.
Ruchi Saxena et al.
Cancer remains a formidable global health challenge requiring the continued exploration of innovative therapeutic approaches. While traditional treatment strategies including surgery, chemotherapy, and radiation therapy have had some succes...
Rebecca Liu,Dean R Buttaci,Caroline L Sokol
Rebecca Liu
Once regarded as distinct systems, the nervous system and the immune system are now recognized for their complex interactions within the barrier tissues. The neuroimmune circuitry comprises a dual-network system that detects external and in...
Mohamed-Ridha Barbouche,Luigi D Notarangelo
Mohamed-Ridha Barbouche
Celiac disease, non-celiac wheat sensitivity, wheat allergy - clinical and diagnostic aspects [0.03%]
乳糜泻、非乳糜泻性小麦敏感和小麦过敏的临床及诊断方面的问题
Ketil Størdal,Kalle Kurppa
Ketil Størdal
In recent years, wheat- and gluten-free diets have increased in demand due to reported increases in various conditions reported to be driven by ingredients of these food products. Celiac disease, wheat allergy and non-celiac wheat sensitivi...
Beyond the Norm: The emerging interplay of complement system and extracellular matrix in the tumor microenvironment [0.03%]
超越常规：肿瘤微环境中补体系统和细胞外基质的相互作用机制及其新兴调控网络
Andrea Balduit,Chiara Agostinis,Roberta Bulla
Andrea Balduit
Ground-breaking awareness has been reached about the intricate and dynamic connection between developing tumors and the host immune system. Being a powerful arm of innate immunity and a functional bridge with adaptive immunity, the compleme...
Kelly S W Lee,Qingyang Zhang,Tatsuya Suwa et al.
Kelly S W Lee et al.
The complement system is increasingly recognised as a key player in tumour progression and response to cancer treatment. Cytotoxic therapies, including chemo- and radiotherapy are standard-of-care for the majority of cancer patients. Cytoto...
Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches [0.03%]
治疗性抗肿瘤抗体激活补体的机制、策略和工程方法
Vitalijs Ovcinnikovs,Karin Dijkman,Gijs G Zom et al.
Vitalijs Ovcinnikovs et al.
The complement system plays an integral role in both innate and adaptive immune responses. Beyond its protective function against infections, complement is also known to influence tumor immunity, where its activation can either promote tumo...
Sachiko Sato,Jun Iwaki,Jun Hirabayashi
Sachiko Sato
In this review, we aim to explore the multifaceted roles of galectins in host defense from a broader perspective, particularly regarding their functions when host integrity is compromised. Numerous comprehensive reviews on galectin function...
Sung-Yao Lin,Edward N Schmidt,Kei Takahashi-Yamashiro et al.
Sung-Yao Lin et al.
Cell surface complex carbohydrates, known as glycans, are positioned to be the first point of contact between two cells. Indeed, interactions between glycans with glycan-binding can modulate cell-cell interactions. This concept is particula...
The complement system in clinical oncology: Applications, limitations and challenges [0.03%]
补体系统在临床肿瘤学中的应用、局限性和挑战
Daniel Ajona,Mark S Cragg,Ruben Pio
Daniel Ajona
The complement system, a key component of innate immunity, is involved in seemingly contradictory aspects of tumor progression and cancer therapy. It can act as an immune effector against cancer and modulate the antitumor activity of certai...