Interplay between the complement system and other immune pathways in the tumor microenvironment [0.03%]
肿瘤微环境中补体系统与其他免疫途径的相互作用
Cecilia Garlanda,Monica Dambra,Elena Magrini
Cecilia Garlanda
Tumor growth and spread are sustained by the tumor microenvironment. Inflammatory cells and pathways have a fundamental role in the tumor microenvironment, driving or conditioning the functional activation of other leukocyte subsets and fav...
Endogenous glucocorticoids and human immunity: Time to revisit old dogmas [0.03%]
内源性糖皮质激素与人类免疫学：是时候重新审视旧观念了
Brinda Bhatt,Luis M Franco
Brinda Bhatt
Glucocorticoids (GCs) are steroid hormones with diverse and important roles in the physiologic response to stress. These include permissive and suppressive effects on immunity, which help prepare the organism for future infectious stressors...
The role of the adaptive immune system in the initiation and persistence of multiple sclerosis [0.03%]
适应性免疫系统在多发性硬化症发病和持续发展中的作用
Ali Maisam Afzali,Thomas Korn
Ali Maisam Afzali
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) in which complex networks of interacting immune cells initiate and sustain the disease. The pathogenesis of relapsing MS is driven by adap...
Mikel Rezola Artero,Andrea Minery,Leon Nedelcev et al.
Mikel Rezola Artero et al.
The hallmarks of cancer are a set of traits that normal cells acquire during their transformation into malignancy. Among the biological processes influencing these hallmarks, the innate immune complement system plays a critical role. It can...
Variable domain glycosylation as a marker and modulator of immune responses: Insights into autoimmunity and B-cell malignancies [0.03%]
可变区的糖基化作为免疫反应标志物和调节因子的见解：自身免疫和B细胞恶性肿瘤
Roxane Biersteker,Oliver F Larsen,Manfred Wuhrer et al.
Roxane Biersteker et al.
Glycosylation of antibodies is essential for shaping immune responses, as it contributes significantly to antibody function and diversity. While immunoglobulin G (IgG) Fc glycosylation is well-characterized, variable domain glycosylation (V...
Interferon regulatory factor 3 beyond innate immunity: Regulation in obesity and metabolic disorders [0.03%]
干扰素调节因子3在先天免疫之外的作用：在肥胖和代谢综合症中的调节作用
Heng Li,Yongliang Zhang,Hong Yong Peh
Heng Li
Interferon regulatory factor 3 (IRF3) is a transcription factor known primarily for its role in antiviral immunity via regulation of type I interferons (IFNs). Recent research has broadened its significance to encompass metabolic disorders,...
The immunological processes behind aquaporin 4-antibody seropositive neuromyelitis optica spectrum disorders [0.03%]
水通道蛋白4抗体血清阳性神经眼肌炎谱系障碍的免疫过程
Monika Bradl,Qian Yu,Yoshiki Takai
Monika Bradl
Ever since the discovery of pathogenic aquaporin 4-specific antibodies in the serum of patients with neuromyelitis optica spectrum disorders current knowledge about clinical observations and diagnosis, and about the underlying pathology and...
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Insights into pathogenesis and biomarkers of prognosis [0.03%]
髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)：发病机制和预后生物标志物的启示
Jane Andersen,Fabienne Brilot
Jane Andersen
MOG antibody-associated disease (MOGAD), an inflammatory demyelinating pathology, is typically associated with the clinical phenotypes acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), or transverse myelitis (TM). The mainst...
Differential immune responses behind different celiac disease manifestations [0.03%]
不同乳糜泻表现背后的差异免疫反应
Esko Kemppainen,Olga Albó,Helka Kaunisto et al.
Esko Kemppainen et al.
In celiac disease (CeD), dietary gluten serves as the driver for a comparatively well characterized small bowel mucosal immune response that generally results in small bowel mucosal villous atrophy and crypt hyperplasia along with a disease...
Sharan Kumar Balaji,Waris Muhammad Khuwaja,Md Liakat Hossain et al.
Sharan Kumar Balaji et al.
Itch is an unpleasant sensation that is encoded by specific sensory neurons called pruriceptors. Itch is associated with almost all skin diseases. Recent studies revealed that many itchy skin diseases are associated with microbiome dysbiosi...