Samagra Agrawal,Govind K Makharia
Samagra Agrawal
Celiac disease and food-allergy are both food-related chronic immune disorders with a common pathogenic link being breakdown in the gut tolerance to otherwise innocuous food antigens. Notwithstanding the similarities, there are significant ...
The pathogenesis of neurological immune-related adverse events following immune checkpoint inhibitor therapy [0.03%]
免疫检查点抑制剂治疗相关的神经系统免疫相关不良事件的发病机制
Magdalena Lerch,Sudarshini Ramanathan
Magdalena Lerch
Cancer is a leading cause of morbidity and mortality worldwide. The development of immune checkpoint inhibitors (ICI) has revolutionised cancer therapy, and patients who were previously incurable can now have excellent responses. These ther...
Acetylation and deacetylation dynamics in stress response to cancer and infections [0.03%]
应激反应中的乙酰化和脱乙酰化动力学：癌症与感染案例分析
Lili Li,Yanqiong Zeng,Genhong Cheng et al.
Lili Li et al.
In response to stress stimuli, cells have evolved various mechanisms to integrate internal and external signals to achieve dynamic homeostasis. Lysine acetyltransferase (KATs) and deacetyltransferase (KDACs) are the key modulators of epigen...
Immune therapies in coeliac disease and food allergies: Advances, challenges, and opportunities [0.03%]
免疫疗法在乳糜泻和食物过敏中的进展、挑战与机遇
Dianne E Campbell,Sam Mehr,Olivia G Moscatelli et al.
Dianne E Campbell et al.
Coeliac disease and food allergy management primarily relies on the strict avoidance of dietary antigens. This approach is challenging to maintain in real-world settings and in food allergy carries the risk of life-threatening anaphylaxis. ...
The spatial and single-cell landscape of skin: Charting the multiscale regulation of skin immune function [0.03%]
皮肤的空间和单细胞景观：绘制皮肤免疫功能多尺度调节图谱
Abiha Kazmi,Raman Gill,Paula Restrepo et al.
Abiha Kazmi et al.
Immune regulation is a key function of the skin, a barrier tissue that exhibits spatial compartmentalization of innate and adaptive immune cells. Recent advances in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) hav...
Endoplasmic reticulum stress: A key player in immune cell regulation and autoimmune disorders [0.03%]
内质网应激：免疫细胞调控和自身免疫性疾病的关键因素
Marion Moreews,Mikael C I Karlsson
Marion Moreews
The endoplasmic reticulum (ER) is a large organelle, found in all eukaryotes, that is essential for normal cellular function. This function encompasses protein folding and quality control, post-translational modifications, lipid regulation,...
Pei Min Thong,Yi Hao Wong,Hardy Kornfeld et al.
Pei Min Thong et al.
The rising prevalence of diabetes mellitus (DM) is undermining global efforts to eliminate tuberculosis (TB). Most studies found that patients with pulmonary TB and DM have more cavitary lung lesions, higher mycobacterial burden on the lung...
From immunobiology to intervention: Pathophysiology of autoimmune encephalitis [0.03%]
从免疫生物学至干预：自身免疫性脑炎的病理生理学
Marie A Homeyer,Alice Falck,Lucie Y Li et al.
Marie A Homeyer et al.
Autoimmune encephalitides (AEs) are neurological disorders caused by autoantibodies against neuronal and glial surface proteins. Nearly 20 years after their discovery, AE have evolved from being frequently misdiagnosed and untreated to a gr...
Jing Yu,Bin-Zhi Qian
Jing Yu
Cellular stress responses are pivotal in maintaining tissue homeostasis and intricately linked with various diseases. Macrophages, a key player of innate immune system, exhibit remarkable plasticity and responsiveness to environmental cues....
The stress and the alarmin-like cytokine interleukin-37 mediated extracellular and intracellular signal pathways [0.03%]
应激和alarmin样细胞因子白介素-37的胞内外信号转导途径研究进展
Yan Li,Nuo Chen,Yaxin Guo et al.
Yan Li et al.
IL-37, as a member of the IL-1 cytokine family, has been extensively characterized as a critical immunoregulatory molecule that suppresses both innate and adaptive immune responses. This cytokine demonstrates constitutive and inducible expr...