Uncovered role of Th9 and IL-9 in rheumatoid arthritis: Current status and future directions [0.03%]
Th9和IL-9在类风湿关节炎中作用的研究现状及未来方向
Jiajie Tu,Weile Chen,Zimeng Xue et al.
Jiajie Tu et al.
Early studies on T helper (Th) 9 cells and their specific cytokine IL-9 mainly focused on the field of allergic diseases. In addition to pathological studies, IL-9 can also affect the normal development and various functions of T cells and ...
Discovery and characterization of vertebrate sialoglycan-binding proteins [0.03%]
脊椎动物唾液酸糖蛋白结合蛋白的发现与鉴定
Liran Adler,Sharon Yehuda,Ajit Varki et al.
Liran Adler et al.
All known life forms feature a dense ensemble of cell surface and extracellular glycans. In vertebrates this includes a high density of sialic acids (Sias), a family of acidic sugars typically capping glycans of cell surface or secreted gly...
A framework for the rational design of oncolytic viruses: A holistic perspective considering the tumour microenvironment [0.03%]
肿瘤微环境综合视角的溶瘤病毒理性设计框架
Dylan Thomas,Priya Bharadwa,Timothy Lee et al.
Dylan Thomas et al.
Oncolytic viruses have played a pioneering role in establishing immunotherapies as the next generation of anti-cancer medicines. Recent works have highlighted the impact the tumour microenvironment has on the efficacy of immunotherapies lik...
Local and Cell-intrinsic complement: The new player in cancer progression [0.03%]
局部和细胞固有的补体系统：癌症进展中的新成员
M Revel,N S Merle
M Revel
The complement system, a key component of innate immunity, has a paradoxical role in cancer, acting both as a tumor suppressor and a promoter. While traditionally recognized for its extracellular immune functions, recent discoveries highlig...
Oncolytic virus-mediated immunomodulation in glioblastoma: Insights from clinical trials and challenges [0.03%]
溶瘤病毒介导的胶质母细胞瘤免疫调节：临床试验启示及挑战
Raziye Piranlioglu,E Antonio Chiocca
Raziye Piranlioglu
The pivotal involvement of the host immune system in cancer therapy has dramatically reshaped therapeutic paradigms, inaugurating the era of immunotherapy. Nonetheless, antigen-specific immunotherapies encounter substantial hurdles within t...
An evolutionary perspective of the roles of galectins in pathogen recognition and immunity [0.03%]
岩藻糖甘露聚糖结合凝集素（galectin）在病原体识别和免疫中的作用的进化观点
Gerardo R Vasta,Gabriel A Rabinovich
Gerardo R Vasta
Protein-glycan interactions, mediated by lectins, are essential for diverse physiological processes, including glycoprotein processing, cell adhesion, communication, signaling, and immune recognition. Lectins, classified into families like ...
Salomé S Pinho,Gabriel A Rabinovich
Salomé S Pinho
Emerging observations at the molecular, cellular, and organismal levels have unveiled critical roles for glycans in regulating a broad range of innate and adaptive immune cell processes. Through interactions with various families of glycan-...
Houcine Hamidi,Idris Boudhabhay,Marie-Agnes Dragon-Durey
Houcine Hamidi
The tumor microenvironment (TME) consists of various immune and non-immune cells, along with proteins from different origins, and plays a crucial role in tumor development, treatment response, and patient prognosis. Complement system is a k...
Unraveling the pathophysiology of narcolepsy type 1 through hypothesis-driven and hypothesis-generating approaches [0.03%]
通过假设驱动和假设生成方法解析1型发作性睡病的病理生理学
Sean A Freeman,Ikram Ayoub,Yves Dauvilliers et al.
Sean A Freeman et al.
Narcolepsy type 1 (NT1) is a chronic orphan neurological sleep disorder characterized by the loss of hypocretin-producing neurons in the lateral hypothalamus, which play a crucial role in wakefulness. Given the genetic association with the ...
Individual- and population-associated heterogeneity in vaccine-induced immune responses. The impact of inflammatory status and diabetic comorbidity [0.03%]
个体和人群的疫苗诱导免疫反应的异质性。炎症状态和糖尿病合并症的影响
Simone A Joosten
Simone A Joosten
Vaccines induce quantitively and qualitatively different effector responses between populations but also between individuals within populations. Several factors are known to affect the success of vaccination, including age, gender, co-infec...