Three's company: The cooperative signals behind the differentiation of Th9 cells [0.03%]
三位一体：Th9细胞分化背后的协同信号作用机制研究
J Alejandra Rodriguez,Humayra Habib,Matthew R Olson
J Alejandra Rodriguez
T helper 9 (Th9) cells, characterized by their production of interleukin-9 (IL-9), play pivotal roles in protective immunity and inflammatory disease. Their differentiation depends on the integration of three signals: TCR engagement (Signal...
Shima Sepehri-Manesh,Marion Debeaud,Valerie Vouret-Craviari
Shima Sepehri-Manesh
The IL-1 family comprises 11 cytokines, including IL-1α, IL-1β, IL-1 receptor antagonist (IL-1Ra), IL-18, IL-33, and IL-36 cytokines to IL-37 and IL-38, that modulate innate immune system activity. In addition to their role in innate immu...
Reovirus oncolysis and the next frontiers for this unique oncoviral immunotherapy [0.03%]
重病毒肿瘤溶解作用及其独特抗癌免疫疗法的未来方向
Negar Sharifi,Amir Emamie,Nastaran Rafiee et al.
Negar Sharifi et al.
Reovirus is one of the most clinically investigated oncolytic viruses, with over 50 clinical trials and more than 1700 patients treated to date. Although it has yet to achieve complete regulatory approval, reovirus remains a promising oncol...
Latest insights into oncolytic viro-immunotherapy with vesicular stomatitis virus [0.03%]
关于用于肿瘤治疗的病毒免疫疗法的最新研究——-vesicular stomatitis病毒为例
Manuela Lizarralde-Guerrero,David Olagnier,Fernando Aranda et al.
Manuela Lizarralde-Guerrero et al.
Vesicular stomatitis virus (VSV), a rhabdovirus with intrinsic oncolytic properties, has emerged as a promising candidate for cancer therapy. Thanks to impaired antiviral responses affecting cancer cells, particularly downregulated type I i...
Oncolytic virotherapy: Sparking durable anti-tumor immunity through microenvironment modulation [0.03%]
溶瘤病毒疗法：通过微环境调控激发持久的抗肿瘤免疫反应
Christoph F Kollmann,Nadine van Montfoort,Pierre Cordelier et al.
Christoph F Kollmann et al.
Oncolytic virotherapy (OVT) is a novel approach to cancer treatment that utilizes viruses to infect and destroy tumor cells selectively. Beyond direct oncolysis, OVT significantly reshapes the tumor microenvironment (TME), activating the ad...
Gut mucosal immune responses - Implications for celiac disease and food allergy [0.03%]
肠黏膜免疫反应-其对乳糜泻和食物过敏的意义
Valérie Abadie
Valérie Abadie
The intestinal mucosa employs a diverse set of defense mechanisms-from mucosal barrier regulation to immunoregulatory pathways-to maintain homeostasis despite constant exposure to microbial and dietary antigens. Failure to establish immune ...
Camillo Bechi Genzano,Tyla Young,Rachel Bonami et al.
Camillo Bechi Genzano et al.
In Type 1 diabetes (T1D), pancreatic β cells are progressively lost, resulting in insulin insufficiency. Although exogenous insulin is essential for disease management, it is not a cure, and inadequate glycemic control continues to result ...
Diffuse neuropsychiatric lupus: Clinical evidence, immune-mediated mechanisms, and therapeutic insights [0.03%]
弥漫性神经精神狼疮：临床证据、免疫介导机制及治疗见解
Rachel Weissman-Tsukamoto,Kaitlin R Carroll,Betty Diamond
Rachel Weissman-Tsukamoto
Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) occur in more than half of patients with SLE, with symptoms including fatigue, anxiety, depression, pain, psychosis, and cognitive dysfunction. These symptoms are often...
Alberto Caminero,Elisa Sánchez-Martínez,Mark Wulczynski et al.
Alberto Caminero et al.
Approximately 20 % of the global population reports adverse reactions to foods, with food allergy and celiac disease being the most well-characterized conditions. Although they involve distinct pathological mechanisms, both are recognized a...
Epigenetic mechanisms in HCC immune landscape: Therapeutic implications [0.03%]
肝细胞癌免疫微环境中表观遗传调控的机制及治疗意义
Maite G Fernandez-Barrena,Iker Uriarte,Pablo Sarobe et al.
Maite G Fernandez-Barrena et al.
Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor and is currently a major cause of cancer-related mortality worldwide. The arrival of immune checkpoint inhibitors (ICI), and their combination with anti-VEGF/VEGFR anti...