Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis [0.03%]
中性粒细胞的程序性细胞死亡：从凋亡到NETosis和细胞焦亡
Léonie Dejas,Karin Santoni,Etienne Meunier et al.
Léonie Dejas et al.
Neutrophils are among the most abundant immune cells, representing about 50%- 70% of all circulating leukocytes in humans. Neutrophils rapidly infiltrate inflamed tissues and play an essential role in host defense against infections. They e...
Mehdi Benamar,Qian Chen,Monica Martinez-Blanco et al.
Mehdi Benamar et al.
Regulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells ar...
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences [0.03%]
化学调节Gasdermin D活性：治疗意义及后果
Bowen Zhou,Derek W Abbott
Bowen Zhou
The gasdermin family of proteins are central effectors of the inflammatory, lytic cell death modality known as pyroptosis. Characterized in 2015, the most well-studied member gasdermin D can be proteolyzed, typically by caspases, to generat...
The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions [0.03%]
上皮屏障：过敏、自身免疫和代谢性疾病以及慢性神经精神疾病的门户
Duygu Yazici,Ismail Ogulur,Yagiz Pat et al.
Duygu Yazici et al.
Since the 1960 s, our health has been compromised by exposure to over 350,000 newly introduced toxic substances, contributing to the current pandemic in allergic, autoimmune and metabolic diseases. The "Epithelial Barrier Theory" postulates...
The noncanonical inflammasome-induced pyroptosis and septic shock [0.03%]
非 canonical 型炎症小体诱导的细胞焦亡与脓毒症Shock
Junru Wu,Jingjing Cai,Yiting Tang et al.
Junru Wu et al.
Sepsis remains one of the most common and lethal conditions globally. Currently, no proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth understanding of the pathogenesis of sepsis is needed to propel t...
Jörg J Goronzy,Nan-Ping Weng
Jörg J Goronzy
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging [0.03%]
超越青春：从免疫衰老的角度理解CAR T细胞的适应度
Julia Han Noll,Bruce L Levine,Carl H June et al.
Julia Han Noll et al.
Population aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over...
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS [0.03%]
与疫苗反应性相关的基线免疫状态(BIS)及其影响因素
Djamel Nehar-Belaid,Mark Sokolowski,Sathyabaarathi Ravichandran et al.
Djamel Nehar-Belaid et al.
Vaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among i...
Better safe than sorry: Naive T-cell dynamics in healthy ageing [0.03%]
安全胜于遗憾：健康老龄化中的 naive T 细胞动力学
Rob J de Boer,Kiki Tesselaar,José A M Borghans
Rob J de Boer
It is well-known that the functioning of the immune system gradually deteriorates with age, and we are increasingly confronted with its consequences as the life expectancy of the human population increases. Changes in the T-cell pool are am...
A Elisabeth Gressler,Houfu Leng,Heidi Zinecker et al.
A Elisabeth Gressler et al.
Aging leads to a decline in immune cell function, which leaves the organism vulnerable to infections and age-related multimorbidities. One major player of the adaptive immune response are T cells, and recent studies argue for a major role o...