Mitochondrial dysfunction as a driver of chronic pain: New insights and therapeutic prospects [0.03%]
线粒体功能障碍在慢性疼痛发病中的驱动作用：新见解与治疗前景
Yi-Lin Fan,Fang-Yu Dai,Jia-Yi Wang et al.
Yi-Lin Fan et al.
Chronic pain is a significant global health burden often resistant to conventional analgesics. Evidence implicates that mitochondrial dysfunction is not only a cellular consequence of injury, but also a fundamental driver of pain chronifica...
MDA-9/Syntenin small molecule inhibitor IVMT-Rx-4 blocks prostate cancer bone metastasis [0.03%]
MDA-9/ syntentin小分子抑制剂IVMT-Rx-4可阻断前列腺癌骨转移
Santanu Maji,Amit Kumar,Padmanabhan Mannangatti et al.
Santanu Maji et al.
Bone metastasis is a frequent and incurable consequence of advanced prostate cancer (PC). This process originates through an interplay between disseminated tumor cells and heterogeneous bone resident cells in the metastatic niche. Melanoma ...
Tribbles pseudokinases in cardiovascular diseases: Molecular mechanisms, genetic insights, and therapeutic prospects [0.03%]
心血管疾病的Tribbles假激酶：分子机制、遗传学见解和治疗前景
Wenkang Zhang,Minhao Zhang,Ziqi Sha et al.
Wenkang Zhang et al.
Cardiovascular disease (CVD) represents a significant global public health challenge, with its high incidence and mortality rates imposing a substantial socioeconomic burden. Tribbles family proteins (TRIB1, TRIB2, and TRIB3), functioning a...
Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of vitamin D receptor (VDR) in the epigenomic network [0.03%]
维生素D缺乏影响子宫内膜蜕膜化的作用及维生素D受体介导的表观遗传机制研究
MyeongJin Yi,Skylar G Montague Redecke,Tianyuan Wang et al.
MyeongJin Yi et al.
Identifying the factors that regulate female reproduction is crucial to understanding how the environment affects female reproductive health. The vitamin D receptor (VDR) and its ligands (primarily 1,25(OH)2D3) have a recognized role in cal...
Self-organizing neural network-based generative AI with embedded error inflation control enhances effective knowledge extraction from preclinical studies with reduced sample size [0.03%]
基于自组织神经网络的生成式AI，嵌入错误膨胀控制，从减少样本量的临床前研究中有效提取知识增强
Jörn Lötsch,Benjamin Mayer,Natasja de Bruin et al.
Jörn Lötsch et al.
Small sample sizes in preclinical research limit the extraction of reliable knowledge and hinder translational progress. We propose genESOM, a generative artificial intelligence method based on emergent self‑organizing maps. genESOM is des...
Gut microbiota drives dietary lignans to improve perimenopausal depression via activating hippocampal ERβ/GluN2A/PSD95 pathway [0.03%]
肠道微生物组通过激活海马ERβ/GluN2A/PSD95通路将膳食木脂素驱动为改善围绝经期抑郁
Chao Yang,Xun Zhang,Jindi Bie et al.
Chao Yang et al.
Dietary lignans (Diet-LIG) are a class of estrogenic plant polyphenols whose improve potential for perimenopausal depression (PMD), a condition driven by estrogen deficiency, remains unexplored. This study aims to investigate whether Diet-L...
Overcoming stromal resistance in solid tumors with MMP2-engineered CAR-T cells [0.03%]
利用MMP2工程化CAR-T细胞克服实体瘤基质抵抗性
Jiaxin Tu,Yuge Zhu,Xinyu Li et al.
Jiaxin Tu et al.
Chimeric antigen receptor (CAR) T-cell therapy remains ineffective in most solid tumors due to extracellular matrix (ECM)-mediated stromal barriers. While prior ECM-remodeling strategies using multiple matrix metalloproteinases (MMPs) impro...
Senkyunolide H potentiates bone marrow-derived mesenchymal stem cells therapy for liver cirrhosis by targeting MAEA to enhance ERK-driven HGF secretion [0.03%]
Senkyunolide H通过靶向MAEA增强ERK驱动的HGF分泌来促进骨髓来源的间充质干细胞治疗肝硬化
Yue Liang,Ying-Lin Zhang,Tian-Yu Cheng et al.
Yue Liang et al.
Pharmacological preconditioning of mesenchymal stem cells (MSCs) is a promising strategy to enhance their therapeutic efficacy for end-stage liver disease; however, maximizing this benefit remains a major clinical challenge. Senkyunolide H ...
Lactobacillus johnsonii and 3-indolepropionic acid improve the depression-like behaviors via inhibiting neuroinflammation [0.03%]
乳酸菌约翰逊菌和3-吲哚丙酸通过抑制神经炎症来改善类似抑郁的行为
Jing Xie,Yongzhi Zhang,Jiao-Lin Wang et al.
Jing Xie et al.
Gut microbiota-derived metabolites play a crucial role in depression. This study aimed to elucidate the role of tryptophan metabolites herein. In a CSDS mouse model, we identified eight differential species, twelve altered neurotransmitters...
Fenofibrate targets PPARα-CPT1C axis to reverse aging by regulating lipid metabolism and mitochondrial function [0.03%]
苯扎贝特通过调控脂代谢和线粒体功能靶向PPARα-CPT1C轴逆转衰老
Yanying Zhou,Yixin Chen,Linlin Zhu et al.
Yanying Zhou et al.
Aging poses a growing global health burden, creating an urgent need for effective interventions. This study reveals that fenofibrate, a clinically approved drug for hyperlipidemia, exerts significant anti-aging effects by targeting fundamen...