Properties of FDA-approved small molecule protein kinase inhibitors: a 2026 update [0.03%]
美国FDA批准的小分子蛋白激酶抑制剂的属性(截至2026年)
Robert Roskoski Jr
Robert Roskoski Jr
Because of the dysregulation of protein kinase activity in many neoplastic and inflammatory diseases, protein kinases are among the most significant drug targets in the 21st century. Of the 94 FDA-approved protein kinase inhibitors, ten wer...
From Gasotransmitter to Therapeutic Insight: Unraveling the Role of H₂S in the Gut-Liver Axis during NAFLD [0.03%]
从Gasotransmitter到治疗见解：揭示H₂S在NAFLD期间肠道-肝脏轴中的作用
Huimin Kang,Yongjia Feng,Baodong Wang et al.
Huimin Kang et al.
Non-alcoholic fatty liver disease (NAFLD) is a widespread chronic liver condition with intricate pathogenesis and poses substantial challenges for clinical management. The gut-liver axis is integral to the pathogenesis of NAFLD, and hydroge...
Xiaoyaosan and isoliquiritigenin remodel depression-associated chromatin 3D structure and phase separation of NF-κB1 [0.03%]
逍遥散和异甘草素重塑与抑郁症相关的染色体三维结构及NF-κB1相分离
Lili Fan,Xiaowei Mo,Ranran Dai et al.
Lili Fan et al.
Xiaoyaosan (XYS) is a classical traditional prescription with well-documented antidepressant effects. However, the active components and molecular mechanisms to alleviate depression remain unclear. In this study, using chronic social defeat...
YBX1-LDHB axis orchestrates pyruvate production from lactate to promote ICC initiation and development [0.03%]
LDHB介导的乳酸向丙酮酸转化促进ICC发生发展
Yong Liu,Fei Wang,Mi Zhang et al.
Yong Liu et al.
Previous work from our group established that Y-box binding protein 1 (YBX1) plays a pivotal role in the initiation and progression of intrahepatic cholangiocarcinoma (ICC); however, its specific biological functions and underlying regulato...
Immunometabolic reprogramming of macrophages: Emerging roles in skeletal muscle regeneration and therapeutic perspectives [0.03%]
巨噬细胞的免疫代谢重编程在肌肉再生中的新兴作用及治疗前景
Si-Jing Li,Xing-Ling He,Xiao-Jiao Zhang et al.
Si-Jing Li et al.
Skeletal muscle regeneration is a complex and strictly regulated process that involves complex interactions between immune cells, muscle-resident progenitor cells, and stromal components. Macrophages play a central role in this process by c...
Reply to letter to the editor questions and comments on "ALKBH5 attenuates mitochondrial fission and ameliorates liver fibrosis by reducing Drp1 methylation" [0.03%]
对编辑来信中关于“ALKBH5通过降低Drp1甲基化抑制线粒体分裂并改善肝纤维化”的问题与评论的回复
Juan Wang,Hui Tao,Chao Lu et al.
Juan Wang et al.
Mitochondrial semi-autonomous inheritance in cardiovascular pathology: emerging mechanisms and therapeutic opportunities [0.03%]
心血管病理中线粒体半自主遗传：新兴机制与治疗机会
Xinyue Xie,Tianhang Yu,Wei Deng et al.
Xinyue Xie et al.
Cardiovascular diseases (CVDs) continue to be a leading contributor to morbidity and mortality worldwide, with mitochondrial dysfunction emerging as a key pathological hallmark. As semi-autonomous organelles, mitochondria regulate cellular ...
Ubong S Ekperikpe,Serena Zhao,Ilse S Daehn
Ubong S Ekperikpe
Chronic kidney disease (CKD) is a leading cause of death worldwide. Currently available drugs slow but do not cure or prevent progression to end-stage kidney disease. Unfortunately, dialysis and kidney transplant not only pose severe lifest...
Questions and comments on "ALKBH5 attenuates mitochondrial fission and ameliorates liver fibrosis by reducing Drp1 methylation," published in Pharmacological Research (2023) [0.03%]
关于“ALKBH5通过减少Drp1甲基化来抑制线粒体分裂并改善肝纤维化”的问题与讨论
Bing Bai,Wenming Bao,Ling Wang et al.
Bing Bai et al.
A CARM1-targeted therapeutic peptide suppresses breast cancer progression both in vitro and in vivo [0.03%]
一种针对CARM1的治疗多肽可同时抑制乳腺癌的发展及恶化
Bing-Ling Peng,Jun Hong,Zi-Rui Wang et al.
Bing-Ling Peng et al.
Coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) is well-known for its essential physiological functions and its pivotal role in the development and progression of various cancers. Targeted inhibition of CARM1 activity has ...