Targeting RNA quality-control defects in tauopathies: Pharmacodynamic biomarkers and therapeutic development [0.03%]
针对Tau病理性改变的RNA质量控制缺陷：药理动力学生物标志物和药物开发
Min Zhang,Aifang Cheng
Min Zhang
Tau-directed therapies can achieve biochemical target engagement without delivering consistent clinical benefit, suggesting that a key bottleneck in tauopathy development lies not only in target access, but in whether tau engagement leads t...
PET radiotracers targeting MDM2 protein interaction: From preclinical validation to first-in-human studies [0.03%]
靶向MDM2蛋白作用的正电子发射断层扫描放射示踪剂：从临床前验证到首次人体研究
Chengxue He,Zhen Wang,Nina Zhou et al.
Chengxue He et al.
Current imaging techniques inadequately delineate surgical margins of well-differentiated liposarcoma (WDLS), increasing risks of incomplete resection or overtreatment. MDM2, a p53-inhibiting oncoprotein amplified in WDLS, represents a dual...
Mapping BAFF/APRIL dependency across autoimmune diseases: A mechanistic framework for understanding differential therapeutic responses [0.03%]
自身免疫性疾病中BAFF/APRIL依赖性的分布情况：理解不同治疗反应的机制框架
Wen Liu,Yang Zheng,Zhendong Feng et al.
Wen Liu et al.
B-cell-targeted therapies have substantially improved outcomes in autoimmune diseases, yet the limitations of non-selective B-cell depletion-including relapse, hypogammaglobulinemia, and infection-have prompted a shift from indiscriminate e...
Hypoxia-driven immune resistance to anti-PD-1/PD-L1 therapy: Mechanistic insights and therapeutic opportunities [0.03%]
低氧驱动的抗PD-1/PD-L1免疫治疗抵抗：机制见解与治疗机会
Kaining Gao,Yunong Li,Xueyi Song et al.
Kaining Gao et al.
Immune checkpoint blockade targeting programmed death protein-1 (PD-1) and its ligand PD-L1 has shown substantial therapeutic benefit in only a subset of patients with solid tumors, highlighting the urgent need to improve cancer immunothera...
Crosstalk between ion homeostasis and lipid peroxidation: Mechanisms and translational opportunities in regulated cell death [0.03%]
离子稳态与脂质过氧化互作的机制及在细胞程序性死亡中的转化机遇
Xinyan Chen,Zixian Xiong,Yaoqing Xie et al.
Xinyan Chen et al.
The expanding landscape of regulated cell death (RCD)-encompassing ferroptosis, cuproptosis, pyroptosis, and apoptosis-has revealed a highly interconnected signaling network rather than strictly isolated pathways. A critical missing link in...
Targeting Hsc70-Mediated Mitochondrial-Lipid Droplet Crosstalk via Ginsenoside Rb2 Promotes Post-Infarction Cardiomyocyte Regeneration [0.03%]
绞股蓝皂苷Rb2靶向Hsc70介导的线粒体-脂滴串扰促进心梗后心肌细胞再生
Ce Cao,Lili Yang,Min Wang et al.
Ce Cao et al.
Inducing adult cardiomyocyte proliferation to repair the infarcted heart remains a major therapeutic challenge. While metabolic reprogramming is known to drive regeneration, the specific organelle-level mechanisms governing this process, pa...
Circulating ATP from hepatic ischemia-reperfusion drives remote cardiac injury via macrophage inflammasome activation [0.03%]
肝脏缺血再灌注损伤释放的循环细胞外三磷酸腺苷通过巨噬细胞炎症小体途径导致远端心脏损伤
Zheng Zhang,Yi Duan,Fulei Gu et al.
Zheng Zhang et al.
Cardiac complications after major hepatic surgery are frequent, yet how hepatic ischemia-reperfusion injury (HIRI) damages the remote heart is unknown. In 382 hepatectomy patients, the incidence of myocardial injury after noncardiac surgery...
Epitranscriptomic circuits wiring the tumor microenvironment: A pharmacodynamic framework for clinical translation [0.03%]
表观转录组学调控线路构建肿瘤微环境的机制及临床转化的药理学框架
Reza Izadpanah,Amin Izadpanah,Eckhard U Alt
Reza Izadpanah
Epitranscriptomic RNA marks have moved from molecular footnotes to a control layer deciding which transcripts are translated, stored or discarded. In solid tumors, this layer sits directly upstream of how the tumor microenvironment behaves:...
The Regulatory Mechanisms of Indole-3-Carboxaldehyde in Immune Cells and Its Role in Autoimmune Diseases [0.03%]
吲哚-3-甲醛在免疫细胞中的调控机制及其在自身免疫性疾病中的作用
Ying Xin,Qiuyu Cen,Jingyuan He et al.
Ying Xin et al.
Immune cells play a central role in the pathogenesis and progression of autoimmune diseases. Recent evidence indicates that metabolites produced by the gut microbiota are essential for maintaining immune cell homeostasis. Indole-3-carboxald...
Harnessing edible extracellular vesicles for inflammatory bowel disease: From natural immunomodulators to bioengineered oral nanotherapeutics [0.03%]
可食用外泌体在炎症性肠病治疗中的应用：从天然免疫调节剂到生物工程口服纳米药物
Congyi Yang,Jingyi Chen,Yalan Xu et al.
Congyi Yang et al.
Inflammatory bowel disease (IBD) is a chronic, relapsing disorder of the gastrointestinal (GI) tract driven by complex interactions among mucosal immune dysregulation, epithelial barrier degradation, and microbial dysbiosis. Current therapi...