Targeting mitochondrial quality control in Alzheimer's disease: Mechanisms and therapeutic potential of phytomedicines [0.03%]
Zhongying Lin,Shun Zhang,Miao Sun
Zhongying Lin
Alzheimer's disease (AD) is a neurodegenerative disorder driven partly by mitochondrial dysfunction, notably the failure of mitochondrial quality control (MQC). Phytochemicals have emerged as multi-target agents capable of restoring MQC, of...
Dual modulation of lipophagy: From molecular mechanisms to therapeutic interventions in cardiovascular health and disease [0.03%]
Yunxia Wu,Weili Li,Heng Liu et al.
Yunxia Wu et al.
The rising global incidence of cardiovascular diseases (CVDs) poses a serious challenge to public health systems, and there is an urgent need to alleviate this disease burden through innovative treatment strategies. Cardiomyocyte energy met...
AXL prevents amyloid-β-induced microglial ferroptosis by sustaining SLC2A3-mediated mitochondrial respiration [0.03%]
Shuai Liu,Chunjie Yang,Ningjun Zhang et al.
Shuai Liu et al.
Dysregulated iron metabolism is a pivotal driver of Alzheimer's disease (AD). Excess iron promotes Aβ aggregation and tau hyperphosphorylation, thereby accelerating disease progression. Serving as the primary iron reservoir in the central ...
Reconstitution of gut microbiota by medicinal plant isoflavones ameliorates heart failure with preserved ejection fraction [0.03%]
Jinghan Lin,Qianhui Zhu,Tao Wang et al.
Jinghan Lin et al.
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with limited therapeutic options. Gut microbiota and microbiota-derived metabolites impact the progression and severity of HFpEF-related cardiometabolic dysf...
Corrigendum to "Mitochondrial dysfunction and immunoinflammatory remodeling in heart failure: Emerging role of conceptualizationthe mtDNA-cGAS/STING axis and therapeutic opportunities" [Pharmacol. Res. 227 (2026) 108195] [0.03%]
Xi Zhang,Xiangchen Xia,Yanmin Zhang et al.
Xi Zhang et al.
Published Erratum
Pharmacological research. 2026 May:227:108200. DOI:10.1016/j.phrs.2026.108200 2026
Comparative risk of serious infections across biological drugs in patients with psoriatic arthritis or psoriasis: A target trial emulation using the Italian VALORE distributed database network [0.03%]
Andrea Spini,Luca L&#x;Abbate,Ylenia Ingrasciotta et al.
Andrea Spini et al.
Risk of serious infections with biological drugs for psoriasis (PsO) and psoriatic arthritis (PsA) remains uncertain, particularly with long-term exposure and in older adults. We aimed to assess the comparative risk of serious infections am...
Fei-Yan-Qing-Hua decoction inhibits influenza viral replication by enhancing NK cell maturation and activation through the upregulation of JAK/STAT/T-bet signalling axis [0.03%]
Yuhe Ma,Wei Zhang,Xiao Wu et al.
Yuhe Ma et al.
The main obstacle of influenza is that only a small proportion of cases progress to severe disease due to massive viral replication and excessive immune responses, while effective therapeutics for influenza-induced pneumonia are urgently ne...
Mitochondrial Dysfunction and Immunoinflammatory Remodeling in Heart Failure: Emerging Role of the mtDNA-cGAS/STING Axis and Therapeutic Opportunities [0.03%]
Xi Zhang,Xiangchen Xia,Yanmin Zhang et al.
Xi Zhang et al.
Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, with persistent sterile inflammation emerging as a critical driver of maladaptive cardiac remodeling beyond hemodynamic stress alone. Recent advances have repo...
Metabolic control of immunity and inflammation: Mitochondrial dynamics, pharmacological targets, and therapeutic opportunities [0.03%]
Chunling Wang,Wangzheqi Zhang,Yue Shu et al.
Chunling Wang et al.
Immune responses and inflammation are not stand-alone processes linearly regulated by the canonical signaling pathways but complex systems biology events, which are deeply rooted in the metabolic state of cells and dynamically modulated. Ho...
SIRT4-mediated debutyrylation of SUCLG1 rescues myocardial energy failure in HFpEF: Ginsenoside Rb3 as a novel SIRT4-interacting regulator [0.03%]
Xiaohan Yu,Yingfei Guo,Shenfan Liu et al.
Xiaohan Yu et al.
Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular disorder characterized by diastolic dysfunction, metabolic dysregulation and limited therapeutic options. Post-translational modifications (PTMs) are key reg...