Endothelial cell-pericyte interactions in ischemic stroke: From microvascular pathology to repair [0.03%]
缺血性卒中内皮细胞-周细胞相互作用：从微血管病理到修复
Sicheng Feng,Chuxin Zhang,Yang Zhao et al.
Sicheng Feng et al.
Ischemic stroke (IS) is a major neurological disease that causes death and long-term disability worldwide. After ischemic injury, the brain undergoes complex pathological changes. As core components of the blood-brain barrier (BBB), endothe...
Bridging the validation gap: organoids as functional decision systems in drug repurposing [0.03%]
体外类器官模型在药物再定位中的作用及挑战
Massimo Gulisano
Massimo Gulisano
Drug repurposing offers a faster and less costly route to therapeutic development, yet its translational success remains constrained by a critical scientific and evidentiary gap: the absence of human-relevant intermediate validation systems...
Hippocampal Remodeling in Chronic Pain: Structural, Functional, Cellular, Metabolic, and Molecular Mechanisms and Therapeutic Perspectives [0.03%]
慢性疼痛下的海马重塑：结构、功能、细胞、代谢和分子机制及治疗前景
Zhang Yanan,Xing Xiangxin,Chen Wenyu et al.
Zhang Yanan et al.
Chronic pain is a multifaceted condition characterized by persistent nociceptive signaling and maladaptive central nervous system plasticity, in which the hippocampus has emerged as a critical hub of structural, functional, metabolic, and m...
ALY688 Confers Cardioprotection Through Macrophage TGFβ-Mediated Treg/Th17 Mediated Multi-organ Responses [0.03%]
ALY688通过巨噬细胞TGFβ介导的Treg / Th17介导的多器官反应产生心脏保护作用
Jialing Tang,Hye Kyoung Sung,Yubin Lei et al.
Jialing Tang et al.
Emerging evidence implicates intestinal barrier dysfunction and translocation of microbial factors as key drivers of post-myocardial infarction inflammation and cardiac remodeling, yet therapeutic strategies targeting the gut-heart axis rem...
A multi-component intervention enhances intestinal urate excretion and improves metabolic and immune homeostasis in diet-induced hyperuricemia [0.03%]
一项多成分干预增强肠道尿酸排泄并改善饮食诱导的高尿酸血症的代谢和免疫稳态
Mingyuan Fan,Jiushu Yuan,Hongyan Xie et al.
Mingyuan Fan et al.
Background: Although the intestine substantially contributes to daily urate clearance, intestinal urate-lowering strategies remain limited, particularly interventions that coordinately regulate transport, barrier integrit...
Corrigendum to 'Targeting the APOE4-driven peripheral-central immune axis: A new frontier for Alzheimer's disease therapy' [Pharmacological Research (2026), YPHRS_108339] [0.03%]
关于“针对APOE4驱动的外周-中枢免疫轴：阿尔茨海默病治疗的新前沿”的勘误(药理学杂志(2026)，YPHRS_108339)
Yunzhi Shang,Zhiyong Zhai,Lin Cong et al.
Yunzhi Shang et al.
Published Erratum
Pharmacological research. 2026 Jul 27:108355. DOI:10.1016/j.phrs.2026.108355 2026
From multi-target to network synergy: A systematic review of how traditional Chinese medicine acts against myocardial ischemia-reperfusion injury via miRNA-mediated systemic communication [0.03%]
从多靶标到网络协同作用：系统综述中医药如何通过微小核糖核酸介导的全身通讯对抗心肌缺血再灌注损伤
De-Sheng Xu,Jiang-Xuan He,Jia-Hui Yan et al.
De-Sheng Xu et al.
Background: Myocardial ischemia-reperfusion injury (MIRI) refers to further damage to myocardial cells caused by multiple factors after blood flow is restored to the ischemic myocardium. Currently, there is a lack of effe...
Oleoylethanolamide attenuates early skeletal muscle metabolic remodeling induced by short-term high-fat diet exposure [0.03%]
油乙醇酰胺减轻短期高脂饮食诱导的早期骨骼肌代谢重构现象
Marzia Friuli,Barbara Eramo,Nisha Zahid et al.
Marzia Friuli et al.
Obesity develops through progressive metabolic alterations that arise long before overt disease, highlighting the need for pharmacological strategies capable of targeting the earliest tissue adaptations to dietary fat overload. Skeletal mus...
Downregulation of COX-2 expression in liver sinusoidal endothelial cell prevented the formation of liver sinusoidal microthrombi through the AKT/mTOR/TSP-1 axis [0.03%]
通过AKT/mTOR/TSP-1轴下调肝窦内皮细胞COX-2表达防止肝窦微血栓形成
Shuaijie Qian,Can Gan,Chong Zhao et al.
Shuaijie Qian et al.
Liver sinusoidal microthrombosis (LST) is recognized as an initiating event in fibrogenesis and portal hypertension in chronic liver diseases. Liver sinusoidal endothelial cell (LSEC)-derived chemoattractants recruit neutrophils and macroph...
Targeting KLF4 Degradation by Doxycycline Restores Peroxisome Lipid Metabolism and Mitochondrial Energy Production in Acute Kidney Injury [0.03%]
多西环素靶向降解KLF4恢复急性肾损伤中的过氧化物酶体脂代谢和线粒体能量生成
Ji Feng,Zhi-Sheng Yao,Yu-Hong Li et al.
Ji Feng et al.
Acute kidney injury (AKI) is a life‑threatening condition with limited preventive medications. While the transcription factor Krüppel-like factor 4 (KLF4) is critical to AKI pathophysiology, its underlying molecular mechanisms remain inco...