Stem cell clonality -- theoretical concepts, experimental techniques, and clinical challenges [0.03%]
干细胞克隆性：理论概念、实验技术及临床挑战
Ingmar Glauche,Leonid Bystrykh,Connie Eaves et al.
Ingmar Glauche et al.
Here we report highlights of discussions and results presented at an International Workshop on Concepts and Models of Stem Cell Organization held on July 16th and 17th, 2012 in Dresden, Germany. The goal of the workshop was to undertake a s...
Evaluation of the 5mg/g liver iron concentration threshold and its association with morbidity in patients with β-thalassemia intermedia [0.03%]
评估肝铁浓度5mg/g阈值与β-地中海贫血中间型患者发病率的关系
Khaled M Musallam,Maria Domenica Cappellini,Ali T Taher
Khaled M Musallam
Iron overload may still occur in transfusion-independent patients with β-thalassemia intermedia due to increased intestinal iron absorption. In this study, we evaluated the association between iron overload, using a liver iron concentratio...
Obesity is associated with higher overall survival in patients undergoing an outpatient reduced-intensity conditioning hematopoietic stem cell transplant [0.03%]
接受门诊低强度预处理造血干细胞移植的患者肥胖与较高的总生存率相关
José Carlos Jaime-Pérez,Perla R Colunga-Pedraza,Balbina Gutiérrez-Gurrola et al.
José Carlos Jaime-Pérez et al.
Background: The impact of obesity on hematopoietic stem cell transplantation (HSCT) outcome remains controversial and has been considered a relative contraindication for the procedure. We investigated the influence of Bod...
Spectrum of α-thalassemia mutations including first observation of - -(FIL) deletion in Hatay Province, Turkey [0.03%]
包括首次观察到-(FIL)缺失在内的α-地中海贫血突变在土耳其哈塔伊省的分布
Muhammet Murat Celik,Ramazan Gunesacar,Gonul Oktay et al.
Muhammet Murat Celik et al.
Alpha thalassemia (α-thal) is one of the most common genetic disorders in the world. It is characterized by the absence or reduced expression of α-globin genes. The frequency of α-thal mutations in the province of Hatay in South Turkey i...
Aberrant TIRAP and MyD88 expression in B-cell chronic lymphocytic leukemia [0.03%]
B细胞慢性淋巴细胞性白血病中TIRAP和MyD88的异常表达
Halina Antosz,Joanna Sajewicz,Barbara Marzec-Kotarska et al.
Halina Antosz et al.
TIRAP and Myd88 are adaptor proteins for Toll-like receptors-2 and -4 (TLR2/4) which are engaged in transducing the signal to downstream molecules. Several studies have shown the increased role of infection factors in pathogenesis of B cell...
p15Ink4b Functions in determining hematopoietic cell fates: implications for its role as a tumor suppressor [0.03%]
P15INK4B在决定造血细胞命运中的作用及其作为抑癌基因的作用机制
Linda Wolff,Juraj Bies
Linda Wolff
The p15Ink4b gene is frequently hypermethylated in myeloid neoplasia and has been demonstrated to be a tumor suppressor. Since it is a member of the INK4b family of cyclin-dependent kinase inhibitors, it was initially presumed that its loss...
Copy number variations of the F8 gene are associated with venous thromboembolism [0.03%]
F8基因拷贝数变异与静脉血栓栓塞相关性研究
Wei Shen,Yi Gu,Rui Zhu et al.
Wei Shen et al.
Background: Venous thromboembolism (VTE) is a complex disease and several inherited and acquired factors are relevant to its occurrence. Among these, an elevated level of plasma coagulation factor VIII (FVIII) is an estab...
The microRNA hsa-miR-503 inhibits growth of K562 cell line [0.03%]
微小核糖核酸hsa-miR-503可通过抑制K562细胞系的生长诱导白血病细胞凋亡
Papai Roy,Uma B Dasgupta
Papai Roy
Gilbert and Crigler Najjar syndromes: an update of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene mutation database [0.03%]
吉尔伯特和克拉格-内贾尔综合征：更新的UDP葡萄糖醛酸转移酶1家族1型成员1（UGT1A1）基因突变数据库
Giulia Canu,Angelo Minucci,Cecilia Zuppi et al.
Giulia Canu et al.
UGT1A1 enzyme defects are responsible of both Gilbert syndrome (GS) and Crigler-Najjar syndrome (CNS). GS depends on a variant TATAA element (which contains two extra TA nucleotides as compared to the wild type genotype) in the UGT1A1 gene ...
Antibody SPC-54 provides acute in vivo blockage of the murine protein C system [0.03%]
抗体SPC-54可急性阻断小鼠蛋白C系统
Laurent Burnier,José A Fernández,John H Griffin
Laurent Burnier
Multiple protective effects of pharmacological activated protein C (APC) are reported in several organ pathologies. To help evaluate the endogenous murine PC system, we characterized a rat monoclonal anti-mouse PC antibody, SPC-54, which in...