Aldo Ciau-Uitz,Lu Wang,Roger Patient et al.
Aldo Ciau-Uitz et al.
Hematopoietic stem cells (HSCs) are essential for the maintenance of the hematopoietic system. However, these cells cannot be maintained or created in vitro, and very little is known about their generation during embryogenesis. Many transcr...
Sonja Boatman,Francesca Barrett,Sruthi Satishchandran et al.
Sonja Boatman et al.
The zebrafish has become a commonly used model for studying hematopoiesis as a result of its unique attributes. Zebrafish are highly suitable for large-scale genetic and chemical screens compared to other vertebrate systems. It is now possi...
GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas [0.03%]
GFI1B、EVI5和MYB基因与人类BCL6基因合作促进淋巴瘤发展的研究
Beverly W Baron,John Anastasi,Juraj Bies et al.
Beverly W Baron et al.
The BCL6 gene, which is expressed in certain B- and T-cell human lymphomas, is involved with chromosomal rearrangements and mutations in a number of these neoplasms. Lymphomagenesis is believed to evolve through a multi-step accumulation of...
Altered expression of iron regulatory proteins with aging is associated with transient hepatic iron accumulation after environmental heat stress [0.03%]
铁调节蛋白表达的改变与环境热应激后的短暂肝铁积聚有关
Steven A Bloomer,Okhee Han,Kevin C Kregel et al.
Steven A Bloomer et al.
An increasing body of evidence suggests that dysregulation of iron metabolism contributes to age-related pathologies. We have previously observed increased hepatic iron with aging, and that environmental heat stress stimulates a further inc...
Complexity of the alpha-globin genotypes identified with thalassemia screening in Sardinia [0.03%]
塞浦路斯泰山莓筛查中α-球蛋白基因型的复杂性
Raffaella Origa,Maria E Paglietti,Maria C Sollaino et al.
Raffaella Origa et al.
α-Thalassemia commonly results from deletions or point mutations in one or both α-globin genes located on chromosome 16p13.3 giving rise to complex and variable genotypes and phenotypes. Rarely, unusual non-deletion defects or atypical de...
Wei Du,Ozlem Erden,Qishen Pang
Wei Du
Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine involved in systemic inflammation and the acute phase reaction. Dysregulation of TNF production has been implicated in a variety of human diseases including Fanconi a...
Remodeling of human red cells infected with Plasmodium falciparum and the impact of PHIST proteins [0.03%]
恶性疟原虫感染的人红细胞重建及PHIST蛋白的影响
Surendra K Prajapati,Om P Singh
Surendra K Prajapati
In an infected erythrocyte (iRBC), renovation and decoration are crucial for malarial parasite survival, pathogenesis and reproduction. Host cell remodeling is mediated by an array of diverse parasite-encoded export proteins that traffic wi...
Is there any relationship between Le(b) antigen expression and Helicobacter pylori infection? [0.03%]
Le(b)抗原与幽门螺杆菌感染有关系吗？
Mohammad Reza Mahdavi,Abolghasem Amami,Tarang Taghvaie et al.
Mohammad Reza Mahdavi et al.
Introduction: Helicobacter pylori infection is one of the main causes of peptic ulcer. There are some blood groups acting as receptors for the pathogen. Based on this view and previous attempts, we tried to examine the re...
Longitudinal analysis of heart and liver iron in thalassemia major patients according to chelation treatment [0.03%]
不同去铁治疗地中海贫血患者的纵向心肝铁沉积分析
F Danjou,R Origa,F Anni et al.
F Danjou et al.
Iron chelators and nuclear magnetic resonance imaging (MRI) techniques for assessing iron loading in liver and heart have greatly improved survival of thalassemic patients suffering iron overload-associated cardiomyopathy. However, the corr...
Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.) [0.03%]
铁的Availability调节Jmjd6和U2AF(65)通过铁和2-氧oglutarate依赖性双氧化酶介导的protoporphyrin IX脱氧酶的异常剪接
Jasmin Barman-Aksözen,Chantal Béguin,Afzal M Dogar et al.
Jasmin Barman-Aksözen et al.
Erythropoietic protoporphyria (EPP) results from partial deficiency of ferrochelatase (FECH). Genetically, EPP patients differ from asymptomatic mutation carriers at the unmutated FECH allele, the expression of which is modulated by single ...