Subtle adjustments of the glucose-6-phosphate dehydrogenase (G6PD) mutation database and reference sequence [0.03%]
有关葡萄糖-6-磷酸脱氢酶(G6PD)突变数据库和参考序列的细微调整
Stéphane Mazières,Florence Petit,Jean-Michel Dugoujon et al.
Stéphane Mazières et al.
Gauri Khandekar,Pudur Jagadeeswaran
Gauri Khandekar
Factor VII, the initiator of the extrinsic coagulation cascade, circulates in human plasma mainly in its zymogen form, factor VII and in small amounts in its activated form, factor VIIa. However, the mechanism of initial generation of facto...
Identification of a novel UROS mutation in a Chinese patient affected by congenital erythropoietic porphyria [0.03%]
在中国一例先天性红细胞生成性_porphyria_患者中鉴定出一新型_UROS_基因突变
Shanshan Guo,Lu Wang,Xiaojing Li et al.
Shanshan Guo et al.
Phenotypic expression of a novel C282Y/R226G compound heterozygous state in HFE hemochromatosis: molecular dynamics and biochemical studies [0.03%]
HFE基因纯合和嵌合变异型遗传性血色病的表型研究：分子动力学及生化分析
Christine Cézard,Amrathlal Rabbind Singh,Gérald Le Gac et al.
Christine Cézard et al.
Most adults affected with hereditary hemochromatosis are homozygous for a single point mutation of HFE (p.Cys282Tyr). Apart from the compound heterozygous state for the p.Cys282Tyr mutant and the widespread p.His63Asp variant allele, other ...
Hyperbaric oxygen improves engraftment of ex-vivo expanded and gene transduced human CD34⁺ cells in a murine model of umbilical cord blood transplantation [0.03%]
高压氧可改善人CD34⁺细胞体外扩增和基因转染后在胎盘脐带血移植小鼠模型中的植入
Omar S Aljitawi,Yinghua Xiao,Jeff D Eskew et al.
Omar S Aljitawi et al.
Delayed engraftment and graft failure represent major obstacles to successful umbilical cord blood (UCB) transplantation. Herein, we evaluated the use of hyperbaric oxygen (HBO) therapy as an intervention to improve human UCB stem/progenito...
Victoria Moignard,Steven Woodhouse,Jasmin Fisher et al.
Victoria Moignard et al.
Hematopoiesis represents one of the paradigmatic systems for studying stem cell biology, but our understanding of how the hematopoietic system develops during embryogenesis is still incomplete. While many lessons have been learned from stud...
Irene Roberts,David O&#x;Connor,Anindita Roy et al.
Irene Roberts et al.
The high frequency of a unique neonatal preleukaemic syndrome, transient abnormal myelopoiesis (TAM), and subsequent acute myeloid leukaemia in early childhood in patients with trisomy 21 (Down syndrome) points to a specific role for trisom...
Dorso-ventral contributions in the formation of the embryonic aorta and the control of aortic hematopoiesis [0.03%]
胚胎主动脉形成和主动脉造血调控的背腹侧来源
Thierry Jaffredo,Aveline Lempereur,Charlotte Richard et al.
Thierry Jaffredo et al.
The embryonic dorsal aorta plays a pivotal role in the production of the first hematopoietic stem cells (HSCs), the founders of the adult hematopoietic system. HSC production is polarized by being restricted to the aortic floor where a spec...
Margaret H Baron,Andrei Vacaru,Johnathan Nieves
Margaret H Baron
Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form s...
Notch and Wnt signaling in the emergence of hematopoietic stem cells [0.03%]
诺特CH和Wnt信号通路在造血干细胞出现中的作用
Anna Bigas,Jordi Guiu,Leonor Gama-Norton
Anna Bigas
Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC de...