Expression of LYN and PTEN genes in chronic myeloid leukemia and their importance in therapeutic strategy [0.03%]
Lyn和PTEN基因在慢性髓性白血病中的表达及意义研究
Cristian Ferri,Michele Bianchini,Raquel Bengió et al.
Cristian Ferri et al.
Tyrosine kinase inhibitors (TKIs), imatinib, nilotinib and dasatinib, are the current treatment of chronic myeloid leukemia (CML). BCR-ABL1 point mutations are the principal cause of resistance to treatment; however other mechanisms could b...
The canonical transient receptor potential 6 (TRPC6) channel is sensitive to extracellular pH in mouse platelets [0.03%]
小鼠血小板中的Canonical瞬时受体电位6 (TRPC6)通道可感受到细胞外pH值的变化
Alejandro Berna-Erro,Letizia Albarran,Natalia Dionisio et al.
Alejandro Berna-Erro et al.
The canonical transient receptor potential-6 (TRPC6) is a receptor-activated non-selective Ca(2+) channel regulated by a variety of modulators such as diacylglycerol, Ca(2+)/calmodulin or phosphorylation. The present study is aimed to inves...
George J Broze Jr
George J Broze Jr
Acquired factor X (FX) deficiency unrelated to amyloidosis is a rare disorder in which an anti-FX antibody is infrequently detected. A patient with severe bleeding due to a calcium ion-dependent anti-FX IgG antibody is described. The FX aff...
TFR2-related hereditary hemochromatosis as a frequent cause of primary iron overload in patients from Central-Southern Italy [0.03%]
意大利中部和南部人群原发性铁过载的常见原因与TFR2相关的遗传性血色病密切相关
Francesca Clementina Radio,Silvia Majore,Francesco Binni et al.
Francesca Clementina Radio et al.
Objective: Hereditary hemochromatosis (HH) is a common Mendelian disorder of iron metabolism. Eighty percent of northern Europeans descendant HH patients carry the same mutation (p.C282Y) in the HFE gene. Simultaneously, ...
Iron chelation therapy for non-transfusion-dependent thalassemia (NTDT): a status quo [0.03%]
非输血依赖性地中海贫血的铁螯合治疗现状
Ali T Taher,Khaled M Musallam,Vip Viprakasit et al.
Ali T Taher et al.
Cary N Weiss,Keisuke Ito
Cary N Weiss
The ability of hematopoietic stem cells (HSCs) to self-renew and differentiate into progenitors is essential for homeostasis of the hematopoietic system. The longevity of HSCs makes them vulnerable to accumulating DNA damage, which may be l...
Embryonic hematopoiesis [0.03%]
胚胎造血
Rachel Golub,Ana Cumano
Rachel Golub
Blood cells are continually produced from a pool of progenitors that derive from hematopoietic stem cells (HSCs). In vertebrates, the hematopoietic system develops from two distinct waves or generation of precursors. The first wave occurs i...
Association between cardiac T2* magnetic resonance imaging values and endocrine function tests in patients with β-thalassemia major [0.03%]
输血依赖性β-地中海贫血患者心脏T2*与内分泌功能试验结果的相关性分析
Shahina Daar,Khaled M Musallam,Ali Taher et al.
Shahina Daar et al.
Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing [0.03%]
铁缺乏改变了由增强缺氧感应引起的基因表达变异
Xu Zhang,Wei Zhang,Shwu-Fan Ma et al.
Xu Zhang et al.
In congenital Chuvash polycythemia (CP), VHL(R200W) homozygosity leads to elevated hypoxia inducible factor (HIF) levels at normoxia. CP is often treated by phlebotomy resulting in iron deficiency, permitting us to examine the separate and ...
Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report [0.03%]
PIEZO1通道器质性阳离子机械门控通道R2456H杂合突变所致脱水 stomatocytic 贫血1例报告
Boris E Shmukler,David H Vandorpe,Alicia Rivera et al.
Boris E Shmukler et al.