Marshall A Lichtman
Marshall A Lichtman
The diagnosis and molecular analysis of a novel 21.9kb deletion (Qinzhou type deletion) causing α+ thalassemia [0.03%]
α⁺地中海贫血新型21.9 kb缺失（钦州型）的诊断及分子生物学特征分析
Ju Long,Shanhuo Yan,Kegan Lao et al.
Ju Long et al.
α-Thalassemia is a common single-gene genetic disease that can cause Hb Bart's hydrops fetalis and Hb H disease in tropical and subtropical regions. When examining conventional thalassemia genes, an only detected --(SEA) genotype sample ne...
Fluorescence in situ hybridization panel for monitoring of minimal residual disease in patients with double minute chromosomes [0.03%]
检测双微体染色体患者最小残余病灶的原位杂交基因座面板技术
Yongbum Jeon,Seon Young Kim,Miyoung Kim et al.
Yongbum Jeon et al.
A double minute chromosome (dmin) is a small fragment of extrachromosomal DNA bearing amplified genes observed in malignancies. We investigated the incidence and characteristics of dmins in hematologic malignancies, and the quantitative cha...
High-resolution melting analyses for genetic variants in ARID5B and IKZF1 with childhood acute lymphoblastic leukemia susceptibility loci in Taiwan [0.03%]
台湾儿童急性淋巴细胞白血病易感基因位点ARID5B和IKZF1多态性的高分辨率融化分析检测方法研究
Chien-Yu Lin,Meng-Ju Li,Jan-Gowth Chang et al.
Chien-Yu Lin et al.
Background: Childhood acute lymphoblastic leukemia (ALL), a heterogeneous disease that includes multiple subtypes is defined by cell lineage and chromosome anomalies. Previous genome-wide association studies have reported...
Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells [0.03%]
白细胞介素-6通过直接损害人的红白血病细胞株TF-1的红系分化而影响红细胞的生成
Bryan J McCranor,Min Jung Kim,Nicole M Cruz et al.
Bryan J McCranor et al.
Anemia of inflammation or chronic disease is a highly prevalent form of anemia. The inflammatory cytokine interleukin-6 (IL-6) negatively correlates with hemoglobin concentration in many disease states. The IL-6-hepcidin antimicrobial pepti...
Hypoxia and HIFs in regulating the development of the hematopoietic system [0.03%]
缺氧及缺氧诱导因子在造血系统发育中的作用
Parisa Imanirad,Elaine Dzierzak
Parisa Imanirad
Many physiologic processes during the early stages of mammalian ontogeny, particularly placental and vascular development, take place in the low oxygen environment of the uterus. Organogenesis is affected by hypoxia inducible factor (HIF) t...
Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells [0.03%]
红系髓系祖细胞：造血干细胞出现前概念胚的“确定性”造血
Jenna M Frame,Kathleen E McGrath,James Palis
Jenna M Frame
Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the developing conceptus prior to the formation of a permanent blood system. In this review, we summarize the current knowledge regarding the emergence, fate, and...
Gemma Swiers,Christina Rode,Emanuele Azzoni et al.
Gemma Swiers et al.
Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, expl...
James Palis
James Palis
M Baldini,S Forti,A Orsatti et al.
M Baldini et al.
Osteopathy represents a prominent cause of morbidity in patients with beta-thalassemia major (TM) and manifests as osteopenia/osteoporosis. Biochemical turnover markers (BTMs) are considered a useful, non-invasive tool for the clinical foll...