DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome [0.03%]
染色体正常型急性髓系白血病和骨髓增生异常综合征患者的DNMT3A R882基因突变
Doaa El Ghannam,Mona M Taalab,Hayam F Ghazy et al.
Doaa El Ghannam et al.
Several molecular markers have been described that help to classify patients with acute myeloid leukemia (AML), a heterogeneous hematopoietic tissue neoplasm, into risk groups. We determined the frequency of DNMT3A mutations, their associat...
Marcin M Machnicki,Tomasz Stoklosa
Marcin M Machnicki
BRAF oncogenic kinase has become a target for specific therapy in oncology. Genetic characterization of a predominant V600E mutation in melanoma, thyroid cancer, and other tumors became a focus for developing specific inhibitors, such as ve...
Carolyn Glass,Michael Wilson,Ruby Gonzalez et al.
Carolyn Glass et al.
The EVI1 oncogene at human chr 3q26 is rearranged and/or overexpressed in a subset of acute myeloid leukemias and myelodysplasias. The EVI1 protein is a 135 kDa transcriptional regulator with DNA-binding zinc finger domains. Here we provide...
Alessandra Insinga,Angelo Cicalese,Pier Giuseppe Pelicci
Alessandra Insinga
This review discusses the processes of DNA-damage-response and DNA-damage repair in stem and progenitor cells of several tissues. The long life-span of stem cells suggests that they may respond differently to DNA damage than their downstrea...
A yet unreported der(11)t(6;11)(p21;q21) included in a complex karyotype of a refractory anemia with ring sideroblasts and poor prognosis [0.03%]
一个复杂的染色体核型包含的新的der(11) t(6;11)(p21;q21)易位病例报告：难治性环形铁粒幼细胞性贫血伴不良预后
Daiane Correa de Souza,Amanda Faria de Figueiredo,Hasmik Mkrtchyan et al.
Daiane Correa de Souza et al.
Direct antiglobulin ("Coombs") test-negative autoimmune hemolytic anemia: a review [0.03%]
自身免疫性溶血性贫血的直接抗人球蛋白（库姆斯）试验阴性型回顾性研究
George B Segel,Marshall A Lichtman
George B Segel
We have reviewed the literature to identify and characterize reports of warm-antibody type, autoimmune hemolytic anemia in which the standard direct antiglobulin reaction was negative but a confirmatory test indicated that the red cells wer...
Effects of switching from imiglucerase to velaglucerase alfa without dose reduction nor wash out in type 1 Gaucher disease [0.03%]
由伊米苷酶转换至伏糖苷酶α治疗第一型Gaucher疾病而不减少剂量或清洗期的效果分析
Christine Serratrice,Monia Bengherbia,Marine Alessandrini et al.
Christine Serratrice et al.
Transcription factor SCL/TAL1 mediates the phosphorylation of MEK/ERK pathway in umbilical cord blood CD34⁺ stem cells during hematopoietic differentiation [0.03%]
转录因子SCL/TAL1介导了人脐带血CD34⁺干细胞向系谱分化过程中MEK/ERK途径的磷酸化作用
Rui Qing Zhou,Jia Hui Wu,Yu Ping Gong et al.
Rui Qing Zhou et al.
Transcription factor stem cell leukemia (SCL), also known as the T-cell acute lymphocytic leukemia 1 (TAL1), plays a key role in the regulation of hematopoiesis, but the molecular mechanisms are not well understood. The aim of the present s...
Cigarette smoke induces alterations in the drug-binding properties of human serum albumin [0.03%]
吸烟可改变人血清白蛋白的药物结合特性
Marco Clerici,Graziano Colombo,Francesco Secundo et al.
Marco Clerici et al.
Albumin is the most abundant plasma protein and serves as a transport and depot protein for numerous endogenous and exogenous compounds. Earlier we had shown that cigarette smoke induces carbonylation of human serum albumin (HSA) and alters...
Hemoglobin Constant Spring is markedly high in women of an ethnic minority group in Vietnam: a community-based survey and hematologic features [0.03%]
越南少数民族妇女的血红蛋白恒定弹簧明显较高：社区为基础的调查和血液学特征
Van Hoa Nguyen,Kanokwan Sanchaisuriya,Kasama Wongprachum et al.
Van Hoa Nguyen et al.
A community-based survey was conducted to determine the prevalence and gene frequency of Hemoglobin Constant Spring (Hb CS) and other forms of thalassemia among an ethnic minority in Vietnam. A total of 298 ethnic minority women, the Có-Tu...