Aberrant baseline cytokine profile in patients with newly diagnosed acquired aplastic anaemia correlates with disease severity and the treatment response [0.03%]
新诊断获得性再生障碍性贫血患者的基线细胞因子谱异常与疾病严重程度及治疗反应相关
Rahul Vatsayan,Ankur Jain,Aditya Jandial et al.
Rahul Vatsayan et al.
Background: Immune dysregulation is crucial in the pathogenesis of acquired aplastic anaemia (aAA). There is paucity of data regarding correlation of baseline cytokine profile with treatment response in aAA. ...
Daucosterol regulates JAK2-STAT3 signaling pathway to promote megakaryocyte differentiation [0.03%]
Daucosterol通过调节JAK2-STAT3信号通路促进巨核细胞分化
Zhongkang Zhang,Guangbin Shang,Zhen Lu et al.
Zhongkang Zhang et al.
Immune thrombocytopenia (ITP) is an autoimmune disease caused by the loss of immune tolerance to platelet autoantigens, resulting in reduced platelet production and increased platelet destruction. Impaired megakaryocyte differentiation and ...
Matthew Hudkins,Heather Hamilton,Samantha J Underwood et al.
Matthew Hudkins et al.
COVID-19 disease progression can be accompanied by a "cytokine storm" that leads to secondary sequelae such as acute respiratory distress syndrome. Several inflammatory cytokines have been associated with COVID-19 disease progression, but h...
Decreasing circ_0014614 promotes the differentiation of bone marrow flineage cells into megakaryocytes in essential thrombocythemia via activiation of miR-138-5p/caspase3 axis [0.03%]
circ_0014614表达降低通过激活miR-138-5p/caspase3轴促进原发性血小板增多症骨髓系细胞向巨核细胞分化
Guopan Yu,Xiaofan Chen,Weixiang Lu et al.
Guopan Yu et al.
Background: Circular RNAs (circRNA) are pivotal in hematological diseases. Previous study showed that circ_0014614 (circDAP3) was significantly underexpressed in bone marrow-derived exosomes from essential thrombocythemia...
PKLR mutations in pyruvate kinase deficient Polish patients: Functional characteristics of c.101-1G > A and c.1058delAAG variants [0.03%]
波兰丙酮酸激酶缺乏症患者的PKLR突变：c.101-1G>A和c.1058delAAG变异的功能特征
Karolina Maciak,Aneta Jurkiewicz,Wojciech Strojny et al.
Karolina Maciak et al.
Pyruvate kinase (PK) deficiency is a rare autosomal recessive disorder characterized by chronic hemolytic anemia of variable severity. Nine Polish patients with severe hemolytic anemia but normal PK activity were found to carry mutations in...
Endurance training and hydroxyurea have synergistic effects on muscle function and energetics in sickle cell disease mice [0.03%]
耐力训练和羟基脲对镰状细胞病小鼠肌肉功能和能量代谢的协同作用
Constance P Michel,Laurent A Messonnier,Benoit Giannesini et al.
Constance P Michel et al.
Sickle cell disease (SCD) is an hemoglobinopathy resulting in the production of an abnormal Hb (HbS) which can polymerize in deoxygenated conditions, leading to the sickling of red blood cells (RBC). These alterations can decrease the oxyge...
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage [0.03%]
血小板活化与血液细胞外囊泡：静脉穿刺与短时间血液储存的影响
Ivica Marić,Klemen Žiberna,Ana Kolenc et al.
Ivica Marić et al.
Extracellular vesicles (EVs) as membrane-bound particles released by various cells are potential tools for diagnosis and treatment. Blood cells, particularly platelets, are the source of circulating EVs. ...
Commentary on "unmasking the morphological alteration of erythrocytes among women suffering from PCOS" [0.03%]
《揭开患有多囊卵巢综合征女性红细胞形态变化的面纱》评论
Shuwei Fan,Guomei Shi,Kelan Li
Shuwei Fan
Diamond-Blackfan anemia, the archetype of ribosomopathy: How distinct is it from the other constitutional ribosomopathies? [0.03%]
钻石-布莱克范贫血症，核糖体病的原型：它与其他先天性核糖体病有何不同？
L Da Costa,Narla Mohandas,Ludivine David-NGuyen et al.
L Da Costa et al.
Diamond-Blackfan anemia (DBA) was the first ribosomopathy described in humans. DBA is a congenital hypoplastic anemia, characterized by macrocytic aregenerative anemia, manifesting by differentiation blockage between the BFU-e/CFU-e develop...