Phenotypic screens reveal Plasmodium falciparum genetic factors associated with infection of sickle-trait cells [0.03%]
表型筛选发现与镰状细胞病红细胞感染相关的恶性疟原虫遗传因子
Camilla V Pires,Jenna Oberstaller,Chengqi Wang et al.
Camilla V Pires et al.
Background: Malaria causes over 200 million cases and more than half a million deaths annually. In many African regions, hemoglobinopathies, such as sickle cell trait (HbAS), confer partial protection against severe P. fa...
Prevalence of multi-organ complications in patients with non-transfusion and neo-transfusion dependent thalassemia: a cross-sectional survey [0.03%]
输血依赖和新近输血依赖型地中海贫血患者的多器官并发症患病率：一项横断面调查研究
Antonella Meloni,Laura Pistoia,Paolo Ricchi et al.
Antonella Meloni et al.
This cross-sectional study compared the prevalence of vascular, hepatic, cardiac, endocrine, and bone complications between adult patients with non-transfusion-dependent thalassemia (NTDT) and neo-transfusion-dependent thalassemia (neo-TDT)...
Refractory immune thrombocytopenia with Trex1 mutation positive probable monogenic lupus [0.03%]
Trex1突变阳性难治性免疫性血小板减少症合并可能的单基因狼疮患者
Bhuvnesh Narain Purohit,Vivek Mohan,Varun Capoor et al.
Bhuvnesh Narain Purohit et al.
Burden beyond the cure: Iron overload following pediatric stem cell transplantation [0.03%]
儿童干细胞移植后的铁过载：治愈之外的负担
Yonatan Diamond,Alexandra Satty,Lenat Joffe et al.
Yonatan Diamond et al.
Iron overload (IOL) is an increasingly recognized complication among pediatric and young adult survivors of hematopoietic stem cell transplantation (HSCT) contributing to significant morbidity and mortality. The pathogenesis of IOL post-HSC...
A novel ELANE variant causing severe congenital neutropenia diagnosed in adulthood [0.03%]
成人晚期诊断的导致严重先天性中性粒细胞减少症的新ELANE变异型
Renato Cerqueira,Josefina A P Braga,Elyse Moritz et al.
Renato Cerqueira et al.
Impact of elevated red blood cell membrane cholesterol in sickle cell anemia patients: Effects of BRN-002, a 2-hydroxypropyl-β-cyclodextrin derivate, on red blood cell lipids, deformability, sickling and hemolysis [0.03%]
镰状细胞病患者红细胞膜胆固醇升高的影响：BRN-002（一种2-羟丙基-β-环糊精衍生物）对红细胞脂质、变形性、镰变和溶血的影响
Claire Bordat,Philippe Connes,Philippe Joly et al.
Claire Bordat et al.
Sickle cell anemia (SCA) patients are characterized by poorly deformable and fragile red blood cells (RBCs). Few studies reported an increased cholesterol content in SCA RBC membrane. However, the consequences of this elevated cholesterol l...
Pegcetacoplan for the treatment of warm autoimmune hemolytic anemia: a case report [0.03%]
佩加司他单抗治疗温抗体自身免疫性溶血性贫血的病例报告
Eleni Gavriilaki,Paschalis Evangelidis,Maria Mainou et al.
Eleni Gavriilaki et al.
Methodological strategies to study and elucidate RBC properties and their potential clinical impact on transfused patients [0.03%]
研究和阐明红细胞特性及其对输血患者潜在临床影响的方法学策略
Emmanuel Längst,Michel Prudent
Emmanuel Längst
Transfusion is a life-saving practice that requires regular blood donation from healthy volunteers. Red blood cells (RBCs) are isolated from blood donation and stored as RBC concentrates (RCCs) at 4 °C for 42 to 49 days depending on storag...
Thalidomide confers therapeutic benefit in beta thalassemia patients by enhancing hemoglobin and hematopoietic gene expression: A non-randomized clinical trial [0.03%]
一项非随机临床试验：沙利度胺通过增强血红蛋白和造血基因表达在β型地中海贫血患者中产生治疗效果
Inayat Ur Rahman,Muhammad Tariq Masood Khan,Zahid Ali et al.
Inayat Ur Rahman et al.
Bacground: Transfusion-dependent β-thalassemia (TDT) requires regular transfusions, often causing iron overload and organ damage. Thalidomide, a fetal hemoglobin (HbF) inducer, may reduce transfusion needs, but scientifi...
Hb Lepore Rochester-MN, a novel βδβ double crossover hemoglobin variant [0.03%]
新型βδβ双交换型Lepore-Hb Rochester-MN变异体
Aruna Rangan,Kenneth C Swanson,Michelle Savedra et al.
Aruna Rangan et al.
Introduction: The β-globin gene cluster harbors highly homologous globin genes. Crossover events involving the δ (HBD) and β (HBB) genes result in Lepore (δβ) and anti-Lepore (βδ) hemoglobins (Hbs). Recently, doubl...