WGCNA and LASSO regression-based selection and validation of microRNA biomarkers of β-thalassemia [0.03%]
基于WGCNA和LASSO回归的微小核糖核酸β型地中海贫血生物标志物的选择与验证
Fang Yang,Ling Shi,Sha Su et al.
Fang Yang et al.
Objective: In patients with severe β-thalassemia, fetal hemoglobin (HbF) upregulation may provide an avenue to better therapeutic outcomes. The mechanisms that regulate the expression of HbF, however, are currently uncle...
A case series of cerebrovascular abnormalities in Townes sickle cell mice visualized with magnetic resonance imaging and angiography [0.03%]
磁共振成像和血管造影下观察到的多只托恩斯镰状细胞病鼠的大脑血管异常案例系列分析
Liana Hatoum,Hannah Song Lee,John N Oshinski et al.
Liana Hatoum et al.
Arterial complications in sickle cell disease (SCD), including stenoses and occlusions, are critical contributors to stroke. Townes SCD mice exhibit neurocognitive deficits and micro-vasculopathy, however stenoses and occlusions that could ...
AI for patient education: Insights from DeepSeek's responses on megaloblastic anemia [0.03%]
用于患者教育的人工智能：来自DeepSeek的巨幼细胞性贫血回复分析给我们的启示
Nidhi Chandrashekar Patil
Nidhi Chandrashekar Patil
Phenotypic screens reveal Plasmodium falciparum genetic factors associated with infection of sickle-trait cells [0.03%]
表型筛选发现与镰状细胞病红细胞感染相关的恶性疟原虫遗传因子
Camilla V Pires,Jenna Oberstaller,Chengqi Wang et al.
Camilla V Pires et al.
Background: Malaria causes over 200 million cases and more than half a million deaths annually. In many African regions, hemoglobinopathies, such as sickle cell trait (HbAS), confer partial protection against severe P. fa...
Prevalence of multi-organ complications in patients with non-transfusion and neo-transfusion dependent thalassemia: a cross-sectional survey [0.03%]
输血依赖和新近输血依赖型地中海贫血患者的多器官并发症患病率：一项横断面调查研究
Antonella Meloni,Laura Pistoia,Paolo Ricchi et al.
Antonella Meloni et al.
This cross-sectional study compared the prevalence of vascular, hepatic, cardiac, endocrine, and bone complications between adult patients with non-transfusion-dependent thalassemia (NTDT) and neo-transfusion-dependent thalassemia (neo-TDT)...
Refractory immune thrombocytopenia with Trex1 mutation positive probable monogenic lupus [0.03%]
Trex1突变阳性难治性免疫性血小板减少症合并可能的单基因狼疮患者
Bhuvnesh Narain Purohit,Vivek Mohan,Varun Capoor et al.
Bhuvnesh Narain Purohit et al.
Burden beyond the cure: Iron overload following pediatric stem cell transplantation [0.03%]
儿童干细胞移植后的铁过载：治愈之外的负担
Yonatan Diamond,Alexandra Satty,Lenat Joffe et al.
Yonatan Diamond et al.
Iron overload (IOL) is an increasingly recognized complication among pediatric and young adult survivors of hematopoietic stem cell transplantation (HSCT) contributing to significant morbidity and mortality. The pathogenesis of IOL post-HSC...
A novel ELANE variant causing severe congenital neutropenia diagnosed in adulthood [0.03%]
成人晚期诊断的导致严重先天性中性粒细胞减少症的新ELANE变异型
Renato Cerqueira,Josefina A P Braga,Elyse Moritz et al.
Renato Cerqueira et al.
Impact of elevated red blood cell membrane cholesterol in sickle cell anemia patients: Effects of BRN-002, a 2-hydroxypropyl-β-cyclodextrin derivate, on red blood cell lipids, deformability, sickling and hemolysis [0.03%]
镰状细胞病患者红细胞膜胆固醇升高的影响：BRN-002（一种2-羟丙基-β-环糊精衍生物）对红细胞脂质、变形性、镰变和溶血的影响
Claire Bordat,Philippe Connes,Philippe Joly et al.
Claire Bordat et al.
Sickle cell anemia (SCA) patients are characterized by poorly deformable and fragile red blood cells (RBCs). Few studies reported an increased cholesterol content in SCA RBC membrane. However, the consequences of this elevated cholesterol l...
Pegcetacoplan for the treatment of warm autoimmune hemolytic anemia: a case report [0.03%]
佩加司他单抗治疗温抗体自身免疫性溶血性贫血的病例报告
Eleni Gavriilaki,Paschalis Evangelidis,Maria Mainou et al.
Eleni Gavriilaki et al.