Newborn screening for sickle cell disease in Angola: Implementation challenges and emerging data on hemoglobinopathy prevalence [0.03%]
安哥拉镰状细胞病新生儿筛查的实施挑战及血红蛋白病患病率的数据公布
Miguel Brito,Catarina Ginete,Mariana Jacinto et al.
Miguel Brito et al.
Sickle Cell Disease (SCD) is an autosomal recessive disorder with a substantial global burden. Despite its particularly high incidence in sub-Saharan Africa, early diagnosis remains limited in many countries. The objective of this study was...
Exercise training adaptations on cardiorespiratory fitness and quality of life of patients with sickle cell disease: A systematic review [0.03%]
锻炼训练对镰状细胞病患者心肺功能和生活质量影响的系统评价
Gilson Dorneles,Igor da Silva,Bruna Marmett
Gilson Dorneles
This study aims to assess the effect of endurance training on cardiorespiratory adaptations and health-related quality of life (HRQoL) of patients with sickle cell disease (SCD). Three databases (Pubmed, Embase and Web of Science) were sear...
Clinical outcomes and health-system challenges in congenital afibrinogenemia: a single-centre prospective case series [0.03%]
先天性无纤维蛋白原血症的临床转归和卫生系统挑战：一项单中心前瞻性病例系列研究
Nita Radhakrishnan,Savitri Singh,Archit Pandharipande et al.
Nita Radhakrishnan et al.
Background: Congenital afibrinogenemia is a very rare bleeding disorder which is often life threatening. Data are scarce, and only 29 Indian cases have been officially reported to World Federation of Hemophilia, mostly as...
Kiranmye Reddy,Jonathan D Fish,Jennifer Eng et al.
Kiranmye Reddy et al.
Purpose: To assess the prevalence and severity of transfusion-associated iron overload (IO) in childhood cancer survivors (CCS). Patients and methods: ...
Relationship between PCT, CRP, and IL-6 and postoperative delirium in ICU patients and its influencing factors [0.03%]
ICU患者术后谵妄与PCT、CRP和IL-6的关系及其影响因素
Huayong Song,Lijing Shen,Wen Sun et al.
Huayong Song et al.
Objective: To investigate the relationship of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) with postoperative delirium (POD) in intensive care unit (ICU) patients, and to identify influencing fa...
Ex vivo culture of hematopoietic stem and progenitor cells with platelet lysate: Investigating proliferation and erythroid-megakaryocytic lineage effects [0.03%]
含血小板 lysate 的体外造血干细胞和祖细胞培养：探究其增殖及红系-巨核系分化的影响
Farnaz Pirsavabi,Zahra Najafi,Mohammad Ebrahimi Siahboomi et al.
Farnaz Pirsavabi et al.
Hematopoietic stem and progenitor cells (HSPCs) are valuable for therapies and research due to their self-renewal and differentiation abilities. The ex vivo culture of these cells necessitates conditions that maintain their unique propertie...
Brian D Chen,Amanda Tapia,Eric Boerwinkle et al.
Brian D Chen et al.
Complete blood counts (CBCs) are commonly measured in clinical practice and are associated with different diseases and traits. Statistical adjustment for blood cell abundance or related traits in these metabolomic epidemiology studies is no...
Oxidantscan: A novel biomarker to assess red blood cell susceptibility to oxidative stress in sickle cell disease [0.03%]
新型生物标志物氧化剂扫描：评估镰状细胞病患者红血细胞氧化应激敏感性
C A Hernández,M J M Traets,W W van Solinge et al.
C A Hernández et al.
Red blood cells (RBC) from patients with sickle cell disease (SCD) are continuously exposed to high levels of oxidative stress, which impacts RBC deformability. In this study, we applied a novel technique (oxidantscan) to measure deformabil...
Effects of G-CSF and 5-FU as conditioning regimens in platelet-targeted gene therapy for hemophilia B [0.03%]
G-CSF和5-FU作为造血干细胞移植预处理方案在板层素靶向基因治疗乙型血友病中的作用研究
Wenjue Xu,Huiyan Han,Binbin Li et al.
Wenjue Xu et al.
Platelet-targeted gene therapy for hemophilia entails modifying a patient's hematopoietic stem cells (HSCs) ex vivo to produce platelets containing coagulation factors, offering a potential cure by localized factor release at injury sites. ...
Anti-sickling efficacy and safety of Sailin-HbS, an indigenous Ayurvedic formulation [0.03%]
防治镰状细胞病的印度传统药物Sailin-HbS及其安全性研究
Shruti Bhatt,Anil Bhansali,Apratim Sai Rajesh et al.
Shruti Bhatt et al.
Sickle Cell Disease (SCD) is a hereditary condition characterized by a mutation in globin chains of hemoglobin. Polymerization of deoxygenated sickle hemoglobin (HbS) leads to rigid sickle shaped red blood cells (RBC), the primary cause of ...