In vitro effects of voxelotor on red blood cell senescence and rheological behavior in sickle cell anemia [0.03%]
voxelotor对镰状细胞贫血红血细胞衰老和流变学行为的体外影响
Bita Asghariastanehei,Philippe Connes,Romain Carin et al.
Bita Asghariastanehei et al.
Voxelotor, a hemoglobin S polymerization inhibitor, has been shown to reduce anemia in sickle cell anemia (SCA) but its effects on vaso-occlusive crisis frequency are limited. Its recent market withdrawal due to concerns over treatment-rela...
Should we longitudinally monitor blood viscosity in patients with sickle cell anemia? [0.03%]
我们应该对镰状细胞贫血患者进行血黏度纵向监测吗？
Philippe Connes,Marie Martin,Judith Catella et al.
Philippe Connes et al.
Blood viscosity is recognized as a key determinant in the pathophysiology of vaso-occlusive crises (VOC) in sickle cell anemia (SCA). However, its longitudinal relationship with changes in VOC frequency over time remains poorly understood. ...
Delay in cell infusion improves GVHD and clinical outcomes in severe aplastic anemia patients >30 years receiving unrelated donor hematopoietic stem cell transplantation [0.03%]
供者年龄大于30岁的无关供者造血干细胞移植治疗严重再生障碍性贫血：移植物抗宿主病和临床结局与细胞植入延迟的相关性
Jinrong Zhao,Xiaowei Chen,Liangliang Wu et al.
Jinrong Zhao et al.
Circadian rhythms regulate immune cell activity, but their impact on hematopoietic stem cell infusion remains unclear. This retrospective study evaluated 177 severe aplastic anemia (SAA) patients undergoing unrelated donor hematopoietic ste...
Blood Board: A virtual community of practice for classical hematology education and care improvement [0.03%]
血板：古典血液学教育和护理改善的虚拟实践社区
Richard C Godby,Jennifer Gile,Xavier Andrade-Gonzalez et al.
Richard C Godby et al.
Enhancing access to sickle cell disease diagnosis in Africa using the gazelle® portable digital microchip electrophoresis platform [0.03%]
在非洲使用Gazelle便携式数字微芯片电泳平台增强镰状细胞病诊断的可及性
Arwa Fraiwan,Bernard E Ebruke,Abubakar Gezawa et al.
Arwa Fraiwan et al.
Sickle Cell Disease (SCD), a genetic blood disorder, claims the lives of thousands of young children in Africa every year. The World Health Organization estimates that 75% of the diagnosed cases of the disease are within sub-Saharan Africa ...
Albumin fusion of the rVWF fragment rD'D3 reduces internalisation by clearance receptor Stabilin-2 [0.03%]
融合白蛋白减少rVWF片段rD'D3的内吞作用及其与清除受体Stabilin-2的相互作用
Kim G Lieu,Sabine Pestel,Mhairi Maxwell et al.
Kim G Lieu et al.
A recombinant VWF D'D3 albumin fusion protein (rD'D3-FP) has been developed to extend the half-life of co-administered coagulation factor VIII (FVIII) for the treatment of haemophilia A. We examined the impact of albumin fusion of rD'D3 on ...
Managing heavy menstrual bleeding in adolescents with bleeding disorders: Outcomes from a pragmatic LMIC approach [0.03%]
发展中地区实用方法管理青少年出血性疾病患者的重度月经过多结局分析
Sandhya Gupta,Nita Radhakrishnan,Archit Pandharipande et al.
Sandhya Gupta et al.
Background: Heavy menstrual bleeding (HMB) a common manifestation of bleeding disorders in adolescents contributes to anemia, transfusions, and impaired quality-of-life (QOL). Evidence supporting practical management stra...
HbS-β thalassemia mimicking HbSS on DdeI RFLP: Report of a pitfall circumventable by Sanger sequencing and parental testing [0.03%]
HbS-β地中海贫血的DdeI酶切片段多态性（RFLP）分析结果类似HbSS：采用Sanger测序和父母检查可避免误判报告一例
Diksha Dev Yadav,Jasbir Kaur Hira,Sanjeev Chhabra et al.
Diksha Dev Yadav et al.
MRI-derived hepatic fat and its clinical correlates in non-transfusion-dependent thalassemia: a cross-sectional study [0.03%]
非输血依赖性地中海贫血患者肝脏脂肪磁共振值及其临床相关因素：横断面研究
Antonella Meloni,Laura Pistoia,Paolo Ricchi et al.
Antonella Meloni et al.
We quantified hepatic fat fraction (FF) by magnetic resonance imaging (MRI) in non-transfusion-dependent thalassemia (NTDT) patients, and we evaluated its associations with demographic, clinical, and biochemical parameters, tissue iron over...
Inflammatory markers in sickle cell disease during vaso-occlusive crisis [0.03%]
镰状细胞病急性血管阻塞危象期的炎症标志物变化
Kamal Kumar Meher,Pradeep Kumar Mohanty,Satyabrata Meher
Kamal Kumar Meher
Sickle cell disease (SCD) is a monogenic blood disorder in which vaso-occlusive crises (VOC) are the main cause of hospitalization. Along with vascular adhesion, inflammation plays a central role in VOC. This study compared inflammatory and...