Preclusion of methemoglobinemia caused by nitrate drugs in diabetics and nondiabetics: Possible role of Vitamin C [0.03%]
维生素C对糖尿病和非糖尿病患者硝酸盐药物所致高铁血红蛋白症的预防作用
Debashree Das,Souvik Sen,Santanu Bhakta et al.
Debashree Das et al.
The drugs containing nitrates like isosorbide dinitrate, isosorbide mononitrate and glyceryl trinitrate, etc., trigger the oxidation of hemoglobin which is manifested in the pathological disorder named methemoglobinemia. It was considered i...
VCAM1, HMOX1 and NOS3 differential endothelial expression may impact sickle cell anemia vasculopathy [0.03%]
血管细胞粘附分子1、血红素加氧酶1和一氧化氮合成酶3的内皮表达差异可能影响镰状细胞性贫血血管病变
Marisa Silva,Andreia Coelho,Sofia Vargas et al.
Marisa Silva et al.
Endothelial dysfunction plays a major role in sickle cell anemia (SCA) systemic vasculopathy, with upregulation of adhesion molecules (e.g., VCAM-1), decreased nitric oxide bioavailability, and oxidative stress. We aimed to assess the modul...
Pancytopenia and thrombosis defects in zebrafish mutants of Fanconi anemia genes [0.03%]
泛康尼氏贫血症基因的斑马鱼突变体的全血细胞减少和凝血缺陷
Revathi Raman,Ramanagouda Ramanagoudr-Bhojappa,Sanchi Dhinoja et al.
Revathi Raman et al.
Progressive pancytopenia is a common feature observed in DNA crosslink repair deficiency disorder, Fanconi anemia (FA). However, this phenotype has not been recapitulated in single FA gene knockout animal models. In this study, we analyzed ...
Manifestation of paroxysmal nocturnal hemoglobinuria after COVID-19 mRNA vaccination [0.03%]
新冠mRNA疫苗接种后的阵发性夜间血红蛋白尿发作
Kawthar Jarrah,Layal Al Mahmasani,Ali Atoui et al.
Kawthar Jarrah et al.
Chronic lymphocytic leukemia with a transient atypical T-cell proliferation raising concern for T-cell lymphoma [0.03%]
慢性淋巴细胞白血病伴短暂的非典型T细胞增殖导致T细胞淋巴瘤的担忧
Jayalakshmi P Balakrishna
Jayalakshmi P Balakrishna
A case of VEXAS syndrome associated with EBV-associated hemophagocytic lymphohistiocytosis [0.03%]
与EBV相关噬血淋巴组织细胞增生症相关的VEXAS综合征一例报告
Roy L Kao,Audrey A Jacobsen,Charles J Billington Jr et al.
Roy L Kao et al.
Vacuoles, E1, X-linked, autoimmunity, somatic (VEXAS) syndrome is characterized by a pathogenic mutation in UBA1, which leads to protean complications including autoimmunity and myelodysplasia. A 56-year-old man with steroid-dependent, late...
Novel histone deacetylase inhibitor CT-101 induces γ-globin gene expression in sickle erythroid progenitors with targeted epigenetic effects [0.03%]
新型组蛋白去乙酰化酶抑制剂CT-101通过靶向表观遗传作用诱导镰状红系祖细胞中的γ珠蛋白基因表达
Louis H Junker,Biaoru Li,Xingguo Zhu et al.
Louis H Junker et al.
Induction of fetal hemoglobin (HbF) expression ameliorates the clinical severity and prolong survival in persons with sickle cell disease (SCD). Hydroxyurea (HU) is the only FDA-approved HbF inducer however, additional therapeutics that pro...
Prognostic factors associated with COVID-19 related severity in sickle cell disease [0.03%]
与镰状细胞疾病中COVID-19相关严重程度有关的预后因素
Nalan Yurtsever,Vijay Nandi,Yonah Ziemba et al.
Nalan Yurtsever et al.
Background: Equipoise exists regarding sickle cell disease (SCD) as a risk factor for COVID-19 disease severity and variables that increase risk of COVID-19 severity in SCD. Given our health system's large SCD patient cat...
Systemic corticosteroids in the treatment of warm autoimmune hemolytic anemia: A clinical setting perspective [0.03%]
暖型自身免疫性溶血性贫血皮质类固醇治疗的临床分析
Ghada E M Abdallah,Wael A Abbas,Esam A S Elbeih et al.
Ghada E M Abdallah et al.
Introduction: There are unmet answers about the effect of the different forms of corticosteroids in the treatment of the warm autoimmune hemolytic anemia (WAIHA). We aimed to describe the initial response rate and the saf...
Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet count without altering platelet function [0.03%]
Mir-99b/let7e/125a簇的巨核细胞特异性敲除会降低血小板计数但不会改变血小板功能
Seema Bhatlekar,Shancy Jacob,Bhanu K Manne et al.
Seema Bhatlekar et al.
The purpose of this research was to assess the effects of a microRNA (miRNA) cluster on platelet production. Human chromosome 19q13.41 harbors an evolutionarily conserved cluster of three miRNA genes (MIR99B, MIRLET7E, MIR125A) within 727 b...