TMEM16F mediated phosphatidylserine exposure and microparticle release on erythrocyte contribute to hypercoagulable state in hyperuricemia [0.03%]
高尿酸血症中TMEM16F介导的红细胞磷脂酰丝氨酸外翻及微颗粒释放促高凝状态的作用及机制研究
Meishan Yan,Minghui Xu,Zhanni Li et al.
Meishan Yan et al.
The link between hyperuricemia (HUA) and the risk of venous thromboembolism (VTE) has been well established. However, the mechanisms of thrombus generation and the effect of HUA on procoagulant activity (PCA) of erythrocytes remain unclear ...
Anti-TFPI for hemostasis induction in patients with rare bleeding disorders, an ex vivo thrombin generation (TG) guided pilot study [0.03%]
一种用于诱导罕见出血障碍患者止血的抗TFPI的方法：一项体外凝血酶原生成（TG）指导的试点研究
Assaf A Barg,Tami Brutman-Barazani,Einat Avishai et al.
Assaf A Barg et al.
Background: Rare bleeding disorders (RBD) are inherited coagulopathies, whose hemostatic control is based upon replacement therapy. Marstacimab (PF-06741086) is a human monoclonal IgG that targets the Kunitz2 domain of ti...
Hydrops fetalis and failure of hematopoietic stem cell transplantation - A long route to the diagnosis of SPTA1-associated hereditary spherocytosis [0.03%]
胎儿水肿和造血干细胞移植失败——SPTA1相关遗传性球形红细胞增多症诊断的漫长过程
M Svaton,M Sukova,P Sedlacek et al.
M Svaton et al.
Blood cells molecules and diseases in 2022: A fountain of youth [0.03%]
2022年血液细胞分子及疾病研究亮点评述：青春之泉永驻体内
Lionel Blanc,Raffaele Renella
Lionel Blanc
BAALC gene expression tells a serious patient outcome tale in NPM1-wild type/FLT3-ITD negative cytogenetically normal-acute myeloid leukemia in adults [0.03%]
BAALC基因表达在成人细胞遗传学正常的急性髓系白血病（NPM1野生型/FLT3-ITD阴性）中的不良预后作用
Deepak Verma,Rajive Kumar,M Shadab Ali et al.
Deepak Verma et al.
Acute myeloid leukemia with normal cytogenetics (CN-AML) is the largest group of AML patients which is associated with a variegated patient outcome. Multiple molecular markers have been used to risk-stratify these patients. Estimation of ex...
Marshall A Lichtman
Marshall A Lichtman
Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model [0.03%]
Mitapivat 增加 ATP 并降低 SCD 小鼠模型的氧化应激和红细胞线粒体滞留
Zenaide M N Quezado,Sayuri Kamimura,Meghann Smith et al.
Zenaide M N Quezado et al.
Polymerization of deoxygenated sickle hemoglobin (HbS) leads to erythrocyte sickling. Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this reduces 2,3-diphosphoglycerate (2,3-DPG) and increases ATP, f...
Upregulation of cytokine signalling in platelets increases risk of thrombophilia in severe COVID-19 patients [0.03%]
血小板细胞因子信号上调增加严重COVID-19患者血栓形成的风险
Simrandeep Kaur,Anamika Singh,Jaskaran Kaur et al.
Simrandeep Kaur et al.
Abnormal coagulation dynamics, including disseminated intravascular coagulopathy, pulmonary embolism, venous thromboembolism and risk of thrombosis are often associated with the severity of COVID-19. However, very little is known about the ...
Haemoglobin Bristol-Alesha in a child with non-spherocytic severe haemolytic anaemia and marked anisochromic poikilocytosis with basophilic stippling and amorphous intracellular content [0.03%]
布里斯托尔-阿尔斯哈族血红蛋白与非球形严重溶血性贫血及显著异色多染性和嗜碱性点彩红细胞和无定形细胞内物质的关系研究
Joan-Lluis Vives Corrons,Barbara J Bain
Joan-Lluis Vives Corrons
Here we describe a retrospective study of a 10-year-old girl, adopted from India, and referred to the Rare Anemias Unit for the diagnosis of a severe haemolytic anaemia of unknown etiology. Blood film examination revealed markedly abnormal ...
Validation of a predictive model for identifying an increased risk for recurrence in adolescents and young adults with a first provoked thromboembolism [0.03%]
青少年和年轻人首次诱发性血栓栓塞复发风险增加的预测模型验证
Verena Limperger,Antje Torge,Bettina Kiesau et al.
Verena Limperger et al.
Background: To develop and validate a predictive model to determinate patients at increased risk to suffer from recurrence following a first provoked deep vein thrombosis (VTE). ...