Artefactual decrease in the fluorescence intensity of hereditary spherocytosis EMA test related to statins [0.03%]
与他汀类药物相关的遗传性球形红细胞增多症EMA试验荧光强度下降的现象
Bonnot Ruget Mathilde,Demeule Caroline,Titraoui Fatima et al.
Bonnot Ruget Mathilde et al.
Molecular mechanisms underlying the role of HLA-DQ in systemic immune activation in severe aplastic anemia [0.03%]
HLA-DQ在严重再生障碍性贫血系统免疫激活中的作用的分子机制
Yuanyuan Shao,Bingnan Liu,Li He et al.
Yuanyuan Shao et al.
Severe aplastic anemia (SAA) is a bone marrow failure disorder caused by autoimmune dysfunction. The presentation by dendritic cells (DCs) is the key step in initiating the immune response against unknown antigens in SAA patients. In the pr...
Plasma exosomal microRNA expression profiles in patients with high-altitude polycythemia [0.03%]
高原红细胞增多症患者血浆exo囊泡microRNA表达谱分析
Shengyan Wang,Jie Ma,Huiping Qiu et al.
Shengyan Wang et al.
High-altitude polycythemia (HAPC) is a chronic mountain sickness characterized by multiple severe ill-effects. Its pathogenesis is still unclear, and till date, no study has been conducted to investigate the plasma exome profile of Tibetan ...
Long-term bone outcomes in Italian patients with Gaucher disease type 1 or type 3 treated with imiglucerase: A sub-study from the International Collaborative Gaucher Group (ICGG) Gaucher Registry [0.03%]
伊米苷酶治疗的意大利型1或型3戈谢病患者的长期骨骼结局：国际戈谢病注册中心（ICGG）的亚组研究
Maria Domenica Cappellini,Francesca Carubbi,Maja Di Rocco et al.
Maria Domenica Cappellini et al.
Background: Gaucher disease (GD) is a lysosomal storage disorder. We evaluated the "real-world" effectiveness of first-line imiglucerase on long-term bone outcomes in Italian patients in the International Collaborative Ga...
Characterization of peripheral T helper 17 (Th17) cells phenotype in postmenopausal women with estrogen insufficiency [0.03%]
绝经后妇女雌激素缺乏外周T辅助细胞17（Th17）表型的特征化研究
Hetal Bhadricha,Vainav Patel,Anushree Patil et al.
Hetal Bhadricha et al.
Over the past few years, Th17 cells is considered a key player in osteoporosis pathogenesis. Although extensively studied in murine models, comprehensive Th17 cell characterization in osteoporotic women is elusive. We thus aimed to examine ...
Influence of initial clinical suspicion on the diagnostic yield of laboratory enzymatic testing in lysosomal storage disorders. Experience from a multispecialty hospital [0.03%]
初始临床怀疑对多学科医院中溶酶体贮积症实验室酶学检测诊断价值的影响：多学科医院的经验教训
Clara Carnicer-Cáceres,Yolanda Villena-Ortiz,Laura Castillo-Ribelles et al.
Clara Carnicer-Cáceres et al.
Lysosomal storage disorders (LSD) are a group of inherited metabolic diseases mainly caused by a deficiency of lysosomal hydrolases, resulting in a gradual accumulation of non-degraded substrates in different tissues causing the characteris...
Plasma immune mediators as laboratorial biomarkers for Sickle Cell Disease patients according to the hydroxyurea therapy and disease severity [0.03%]
羟基脲治疗和疾病严重程度对镰状细胞病患者血浆免疫介质生物标志物的影响
Sílvia Letícia de Oliveira Toledo,Valéria Sutana Ladeira,Leilismara Sousa Nogueira et al.
Sílvia Letícia de Oliveira Toledo et al.
In the present work, the impact of Sickle Cell Disease (SCD) degrees of severity, as well hydroxyurea treatment on the systemic immunological signatures of patients was evaluated. Based on a high-throughput chemokine, cytokine and growth fa...
Platelet-derived microvesicles activate human platelets via intracellular calcium mediated reactive oxygen species release [0.03%]
血小板源性微囊通过细胞内钙介导的活性氧释放活化人血小板
Pooja Yadav,Samir Kumar Beura,Abhishek Ramachandra Panigrahi et al.
Pooja Yadav et al.
Platelet-derived microvesicles (PMVs) are the most abundant microvesicles in circulation, originating from blood platelets via membrane blebbing. PMVs act as biological cargo carrying key molecules from platelets, including immunomodulatory...
Immunological profile in a pediatric population of patients with spherocytosis. A single-center experience [0.03%]
球形红细胞增多症患者的免疫学特征——单中心报告
Silvio Marchesani,Letizia Sabatini,Valentina Bertaina et al.
Silvio Marchesani et al.
Spherocytosis is a hereditary disease caused by the deficiencies of different membrane proteins of red blood cells. Currently, splenectomy is the main therapeutic strategy available, although it is accompanied by an increased risk of sepsis...
Ultraviolet light oxidation of fresh hemoglobin eliminates aggregate formation seen in commercially sourced hemoglobin [0.03%]
紫外线照射新鲜血红蛋白可消除商业来源的血红蛋白中的聚集现象
Aqeela Afzal,William N Beavers,Eric P Skaar et al.
Aqeela Afzal et al.
Elevated levels of circulating cell-free hemoglobin (CFH) are an integral feature of several clinical conditions including sickle cell anemia, sepsis, hemodialysis and cardiopulmonary bypass. Oxidized (Fe3+, ferric) hemoglobin contributes t...