Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease [0.03%]
Gaucher病Ⅰ型患者的γ球蛋白血症及B淋巴细胞克隆性分析
Predrag Rodic,Sonja Pavlovic,Tatjana Kostic et al.
Predrag Rodic et al.
Introduction: We evaluated a novel approach for investigation of lymphocyte dysregulation in Gaucher patients by including determination of IgH and TCR gene rearrangements together with levels of immunoglobulins, natural ...
Diagnosing Gaucher disease: an on-going need for increased awareness amongst haematologists [0.03%]
提高对戈谢病的认识：血液科医师任重而道远
A S Thomas,A B Mehta,D A Hughes
A S Thomas
Gaucher disease (GD) is an inherited enzyme deficiency characterised by progressive cytopenias, hepatosplenomegaly and destructive bone disease. It is diagnosed by demonstration of beta glucosidase deficiency but may be suspected in presenc...
PAI-1 and IFN-γ in the regulation of innate immune homeostasis during sublethal yersiniosis [0.03%]
PAI-1和IFN-γ在亚致死耶尔森氏菌感染期间调节固有免疫稳态中的作用
Zheng Wang,Qi Zhao,Yuxia Han et al.
Zheng Wang et al.
Plasminogen activator inhibitor type 1 (PAI-l), a key part of the fibrinolytic system, plays a critical host protective role during the acute phase of infection by regulating interferon(IFN)-γ release. IFN-γ regulates PAI-1 expression, wh...
Effect of a group of genetic markers around the 5' regulatory regions of the β globin gene cluster linked to high HbF on the clinical severity of β thalassemia [0.03%]
β珠蛋白基因簇上游调控区一系列与HbF高水平相关的遗传标记对β地贫临床严重程度的影响
Pooja Dabke,Roshan B Colah,K Ghosh et al.
Pooja Dabke et al.
The clinical and hematological course of β thalassemia intermedia is influenced by a number of genetic factors which play a role in increasing fetal haemoglobin levels. Several polymorphisms located in the promoters of β and γ globin gen...
Recovery from hematopoietic injury by modulating prostaglandin E(2) signaling post-irradiation [0.03%]
调控照射后前列腺素E2信号促进造血损伤修复
Jonathan Hoggatt,Pratibha Singh,Kayla N Stilger et al.
Jonathan Hoggatt et al.
While high dose total body irradiation (TBI) is used therapeutically, the proliferation of nuclear weapons, increasing use of nuclear power, and worldwide radical terrorism underscore the need to develop countermeasures to a radiological ma...
Taliglucerase alfa leads to favorable bone marrow responses in patients with type I Gaucher disease [0.03%]
alfa-葡萄糖苷酶 Taliglucerase 治疗戈谢病 I 型患者的疗效良好
L van Dussen,A Zimran,E M Akkerman et al.
L van Dussen et al.
Taliglucerase alfa (Protalix Biotherapeutics, Israel) is a carrot-cell-expressed recombinant human beta-glucocerebrosidase recently approved in the United States for the treatment of type 1 Gaucher disease (GD). As bone disease is one of th...
Markéta Záčková,Darina Moučková,Tereza Lopotová et al.
Markéta Záčková et al.
Heat shock proteins (Hsp) are important for the stability and function of cell proteins and thus for cell survival under physiological as well as stress conditions. Hsps were also reported to play an important role in tumorogenesis includin...
DARC (Duffy) and BCAM (Lutheran) reduced expression in thyroid cancer [0.03%]
甲状腺癌中DARC(Duffy)和BCAM(Lutheran)表达降低
Flavia Roche Moreira Latini,André Uchimura Bastos,Carine Prisco Arnoni et al.
Flavia Roche Moreira Latini et al.
Duffy or DARC (Duffy Antigen Receptor for Chemokines) is a glycosylated membrane protein that selectively binds angiogenic chemokines. Previous in vivo and in vitro studies of DARC function in cancer have associated DARC over expression wit...
The impact of the CYP2C9 and VKORC1 polymorphisms on acenocoumarol dose requirements in a Romanian population [0.03%]
罗马尼亚人群中的CYP2C9和VKORC1基因多态性对醋硝香豆素剂量需求的影响
Anca Dana Buzoianu,Florentina Claudia Militaru,Stefan Cristian Vesa et al.
Anca Dana Buzoianu et al.
Aim: To investigate the genotype-phenotype correlation in Romanian patients treated with acenocoumarol. Material and methods: We studie...
Filippo Vairo,Pâmela Portela,Patrícia H Salim et al.
Filippo Vairo et al.
Background: Gaucher disease (GD) is caused by the reduced activity of lysosomal enzyme glucocerebrosidase, which leads to the accumulation of glucocerebroside in macrophages and a chronic stimulation of the immune system....