Aberrant TIRAP and MyD88 expression in B-cell chronic lymphocytic leukemia [0.03%]
B细胞慢性淋巴细胞性白血病中TIRAP和MyD88的异常表达
Halina Antosz,Joanna Sajewicz,Barbara Marzec-Kotarska et al.
Halina Antosz et al.
TIRAP and Myd88 are adaptor proteins for Toll-like receptors-2 and -4 (TLR2/4) which are engaged in transducing the signal to downstream molecules. Several studies have shown the increased role of infection factors in pathogenesis of B cell...
p15Ink4b Functions in determining hematopoietic cell fates: implications for its role as a tumor suppressor [0.03%]
P15INK4B在决定造血细胞命运中的作用及其作为抑癌基因的作用机制
Linda Wolff,Juraj Bies
Linda Wolff
The p15Ink4b gene is frequently hypermethylated in myeloid neoplasia and has been demonstrated to be a tumor suppressor. Since it is a member of the INK4b family of cyclin-dependent kinase inhibitors, it was initially presumed that its loss...
Copy number variations of the F8 gene are associated with venous thromboembolism [0.03%]
F8基因拷贝数变异与静脉血栓栓塞相关性研究
Wei Shen,Yi Gu,Rui Zhu et al.
Wei Shen et al.
Background: Venous thromboembolism (VTE) is a complex disease and several inherited and acquired factors are relevant to its occurrence. Among these, an elevated level of plasma coagulation factor VIII (FVIII) is an estab...
The microRNA hsa-miR-503 inhibits growth of K562 cell line [0.03%]
微小核糖核酸hsa-miR-503可通过抑制K562细胞系的生长诱导白血病细胞凋亡
Papai Roy,Uma B Dasgupta
Papai Roy
Gilbert and Crigler Najjar syndromes: an update of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene mutation database [0.03%]
吉尔伯特和克拉格-内贾尔综合征：更新的UDP葡萄糖醛酸转移酶1家族1型成员1（UGT1A1）基因突变数据库
Giulia Canu,Angelo Minucci,Cecilia Zuppi et al.
Giulia Canu et al.
UGT1A1 enzyme defects are responsible of both Gilbert syndrome (GS) and Crigler-Najjar syndrome (CNS). GS depends on a variant TATAA element (which contains two extra TA nucleotides as compared to the wild type genotype) in the UGT1A1 gene ...
Antibody SPC-54 provides acute in vivo blockage of the murine protein C system [0.03%]
抗体SPC-54可急性阻断小鼠蛋白C系统
Laurent Burnier,José A Fernández,John H Griffin
Laurent Burnier
Multiple protective effects of pharmacological activated protein C (APC) are reported in several organ pathologies. To help evaluate the endogenous murine PC system, we characterized a rat monoclonal anti-mouse PC antibody, SPC-54, which in...
Altered innate function of plasmacytoid dendritic cells restored by enzyme replacement therapy in Gaucher disease [0.03%]
葡萄糖脑苷脂病患者的浆细胞样树突状细胞固有功能改变可经酶替代治疗恢复
Cécile Braudeau,Julie Graveleau,Marie Rimbert et al.
Cécile Braudeau et al.
Background: Gaucher disease (GD) is caused by an autosomal-recessive deficiency of β-glucocerebrosidase leading to an accumulation of glucosylceramide in monocytes/macrophage lineage. We analyzed immune cells and especia...
Serial echocardiographic left ventricular ejection fraction measurements: a tool for detecting thalassemia major patients at risk of cardiac death [0.03%]
serial测量的左心室射血分数：一个检测出地中海贫血死亡高危患者的方法
Aurelio Maggio,Angela Vitrano,Giuseppina Calvaruso et al.
Aurelio Maggio et al.
Cardiac damage remains a major cause of mortality among patients with thalassemia major. The detection of a lower cardiac magnetic resonance T2* (CMR-T2*) signal has been suggested as a powerful predictor of the subsequent development of he...
Mahmoud M Sirdah,Jürgen Sievertsen,Mansour S Al-Yazji et al.
Mahmoud M Sirdah et al.
Background: β-Thalassemia is a disorder caused by mutations at the hemoglobin β-gene (HBB) locus. Its most important manifestation, the major form, is characterized by severe hypochromic and hemolytic anemia and is inhe...
Circulating microenvironment of CLL: are nurse-like cells related to tumor-associated macrophages? [0.03%]
慢性淋巴细胞白血病的循环微环境：护理样细胞与肿瘤相关巨噬细胞有关吗？
Agata A Filip,Bogumiła Ciseł,Dorota Koczkodaj et al.
Agata A Filip et al.
B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common hematologic malignancies in Western countries. Accumulation of leukemic lymphocytes in peripheral blood, bone marrow and secondary lymphatic organs of CLL patients is due...