Is it time to implement a hemorheology passport in sickle cell disease? [0.03%]
实施镰状细胞病血液流变学护照的时候了吗？
Philippe Connes,Marie Martin,Céline Renoux et al.
Philippe Connes et al.
From blood viscosity to a hemorheology passport: Making sickle-cell monitoring clinically actionable [0.03%]
从血液黏度到血流变护照：使镰状细胞监测具有临床操作性
M Vijayasimha,Srikanth Mulavagili
M Vijayasimha
A real-world analysis of polycythemia vera at two comprehensive cancer centers in Cali, Colombia [0.03%]
哥伦比亚卡利两所综合癌症中心的真实世界性非常见病多血症 vera 分析
Maria Alejandra Urbano,Audrey T Martínez-Caicedo,Humberto Alejandro Nati-Castillo et al.
Maria Alejandra Urbano et al.
Background: Polycythemia vera (PV) is a chronic myeloproliferative neoplasm characterized by the clonal proliferation of hematopoietic stem cells, primarily driven by JAK2 mutations. Even though there are established diag...
Sickle Cell Disease: Can genetic variability influence pregnancy outcomes? [0.03%]
镰形红细胞性疾病：遗传变异会影响妊娠结局吗？
Catarina Ginete,Carolina Cruz,Mariana Delgadinho et al.
Catarina Ginete et al.
Pregnancy in Sickle Cell Disease (SCD), a severe hereditary genetic condition, highly prevalent in Sub-Saharan African countries, is associated with increased risk of complications and severe outcomes in pregnancy, like intrauterine growth ...
Analysis of B cell dynamic changes and pivotal drivers based on single-cell transcriptome of peripheral blood in sepsis [0.03%]
基于外周血单细胞转录组的脓毒症B淋巴细胞动态变化及关键驱动因素分析
Xiuming Zhuo,Gangren Jian,Hongyi Chen
Xiuming Zhuo
Background: Sepsis mortality stems from infection-triggered immune dysregulation, causing multiple organ dysfunction. B cells, key to adaptive immunity, protect against infection and regulate inflammation through antibodi...
Clinical and molecular characterization of Hb Coimbra [HBB: c.300T>A p.(Asp100Glu)] in a three-generation Italian family: From diagnostic pitfalls to vascular risk [0.03%]
科英布ра血红蛋白[HBB:c.300T>A p.(Asp100Glu)]的临床和分子特征：来自意大利一家三代人的研究从诊断陷阱到血管风险评估
Francesco Pezzoli,Elena Chiocca,Annalisa Tondo et al.
Francesco Pezzoli et al.
Background: High oxygen-affinity hemoglobin (HOAH) variants are rare causes of familial secondary erythrocytosis. Hb Coimbra [HBB: c.300T>A p.(Asp100Glu)] is a rare variant that can mimic β-thalassemia traits on HPLC, le...
Invisible in the system: Fragmented data and territorial inequalities in sickle cell disease in Brazil [0.03%]
隐形的系统：巴西镰状细胞病的数据碎片化和地域不平等
Carlos André Nogueira,Isabelle Ribeiro Barbosa
Carlos André Nogueira
Sickle cell disease (SCD) is a genetic disorder strongly shaped by social, racial, and territorial inequalities. We identified, mapped, and characterized the population living with SCD in a state in Northeast Brazil and examined how fragmen...
In vitro effects of voxelotor on red blood cell senescence and rheological behavior in sickle cell anemia [0.03%]
voxelotor对镰状细胞贫血红血细胞衰老和流变学行为的体外影响
Bita Asghariastanehei,Philippe Connes,Romain Carin et al.
Bita Asghariastanehei et al.
Voxelotor, a hemoglobin S polymerization inhibitor, has been shown to reduce anemia in sickle cell anemia (SCA) but its effects on vaso-occlusive crisis frequency are limited. Its recent market withdrawal due to concerns over treatment-rela...
Should we longitudinally monitor blood viscosity in patients with sickle cell anemia? [0.03%]
我们应该对镰状细胞贫血患者进行血黏度纵向监测吗？
Philippe Connes,Marie Martin,Judith Catella et al.
Philippe Connes et al.
Blood viscosity is recognized as a key determinant in the pathophysiology of vaso-occlusive crises (VOC) in sickle cell anemia (SCA). However, its longitudinal relationship with changes in VOC frequency over time remains poorly understood. ...
Delay in cell infusion improves GVHD and clinical outcomes in severe aplastic anemia patients >30 years receiving unrelated donor hematopoietic stem cell transplantation [0.03%]
供者年龄大于30岁的无关供者造血干细胞移植治疗严重再生障碍性贫血：移植物抗宿主病和临床结局与细胞植入延迟的相关性
Jinrong Zhao,Xiaowei Chen,Liangliang Wu et al.
Jinrong Zhao et al.
Circadian rhythms regulate immune cell activity, but their impact on hematopoietic stem cell infusion remains unclear. This retrospective study evaluated 177 severe aplastic anemia (SAA) patients undergoing unrelated donor hematopoietic ste...