Manuela G Neuman,Stephen Malnick,Yaakov Maor et al.
Manuela G Neuman et al.
The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical research, translational research, pathogenesis and therapies. A special accent is placed on alcohol misuse, as alcohol is a l...
HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma [0.03%]
HES5通过激活STAT3促进肝癌细胞增殖和侵袭并提示不良预后
Guizhou Zhu,Weidong Shi,Hui Fan et al.
Guizhou Zhu et al.
Objectives: HES5 is a member of the basic helix-loop-helix (bHLH) family of transcription factors, and involved in cell differentiation and proliferation in a variety of tissues other than HCC. Therefore, we have characte...
Low HIP1R mRNA and protein expression are associated with worse survival in diffuse large B-cell lymphoma patients treated with R-CHOP [0.03%]
弥漫大B细胞淋巴瘤患者接受R-CHOP治疗时，HIP1R低表达与预后不良有关
Kah Keng Wong,Ewe Seng Ch&#x;ng,Suet Kee Loo et al.
Kah Keng Wong et al.
Huntingtin-interacting protein 1-related (HIP1R) is an endocytic protein involved in receptor trafficking, including regulating cell surface expression of receptor tyrosine kinases. We have previously shown that low HIP1R protein expression...
Multicenter Study
Experimental and molecular pathology. 2015 Dec;99(3):537-45. DOI:10.1016/j.yexmp.2015.08.019 2015
Hepatitis B virus X protein induces the histone H3 lysine 9 trimethylation on the promoter of p16 gene in hepatocarcinogenesis [0.03%]
乙型肝炎病毒X蛋白通过诱导抑癌基因p16启动子组蛋白H3赖氨酸9三甲基化在肝癌发生中的作用机制研究
Di-Yi Wang,Li-Ping Zou,Xiao-Jia Liu et al.
Di-Yi Wang et al.
Our previous study showed hepatitis B virus X protein (HBx) suppresses the p16 expression in hepatocarcinogenesis. In this study we explored the relationship between HBx and trimethylation of H3K9 (H3K9me3), and elucidated the underlying me...
Changes in microRNAs associated with Twist-1 and Bcl-2 overexpression identify signaling pathways [0.03%]
与Twist-1和Bcl-2过表达相关的微小核糖核酸的变化确定了信号转导途径中的变化
Nan Zhao,Bao-cun Sun,Xiu-lan Zhao et al.
Nan Zhao et al.
Epithelial-mesenchymal transition (EMT) is regulated by multiple signal transduction pathways. Twist-1 is one of the most important transcription factors in these pathways. In a previous study, we found that Bcl-2 enhanced the role of Twist...
Effects of atorvastatin on PDCD4/NF-κB/TNF-α signaling pathway during coronary microembolization of miniature pigs [0.03%]
阿托伐他汀对冠状动脉微栓塞 minipig PDCD4/NF-κB/TNF-α信号通路的影响
Qiang Su,Lang Li,Tao Liu et al.
Qiang Su et al.
Objective: In this study, we explore the effects of pretreatment with atorvastatin on the cardiac function of piglets after coronary microembolization (CME). ...
Mutational analysis by next generation sequencing of gastric type dysplasia occurring in hyperplastic polyps of the stomach: Mutations in gastric hyperplastic polyps [0.03%]
胃型肠上皮内瘤变的突变分析：关于胃增生性息肉中的突变检测研究
Marcela Salomao,Aesis M Luna,Jorge L Sepulveda et al.
Marcela Salomao et al.
Gastric hyperplastic polyps (GHP) are the most common type of polyps occurring in the stomach. Although GHP are broadly interpreted as benign lesions, they may progress to dysplasia and adenocarcinoma. ...
The development of rapid and accurate screening test for RET hotspot somatic and germline mutations in MEN2 syndromes [0.03%]
嗜铬细胞瘤基因RET热点突变的快速准确筛选方法的发展研究
Andrej Zupan,Damjan Glavač
Andrej Zupan
Medullary thyroid carcinoma (MTC) is a rare endocrine malignancy with distinctive features separating it from other thyroid cancers. Cancer may be sporadic or occur as a consequence of the hereditary syndrome called multiple endocrine neopl...
Clinical pathological impacts of microRNAs in papillary thyroid carcinoma: A crucial review [0.03%]
乳头状甲状腺癌中microRNA的临床病理影响：重要综述
Anna Chruścik,Alfred King-yin Lam
Anna Chruścik
MicroRNAs (miRNA) deregulation is an important event in the pathogenesis of papillary thyroid carcinoma. The alternations of miRNAs could be measured at the cancer tissue or serum so that the clinical impacts of them in papillary thyroid ca...
Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice [0.03%]
Hoxc13基因敲除小鼠毛干固醇O酰基转移酶1(Soat1)表达异常调控
Christopher S Potter,Michael J Kern,Mary Ann Baybo et al.
Christopher S Potter et al.
The cholesterol-metabolizing enzyme sterol O-acetyltransferase (SOAT1) is implicated in an increasing number of biological and pathological processes in a number of organ systems, including the differentiation of the hair shaft. While the f...