Wharton's jelly-derived nanovesicles for targeting intervertebral disc degeneration [0.03%]
来源于沃顿胶的纳米囊泡靶向治疗椎间盘退变
Letizia Penolazzi,Alice Zaramella,Anna Chierici et al.
Letizia Penolazzi et al.
The present study was designed to characterize the matrix-bound nanovesicles (MBVs) in decellularized Wharton's jelly matrix (DWJ). We have previously used DWJ as a biomaterial demonstrating its efficacy in restoring the functional properti...
Prevalence and clinical significance of CBP deficiency and disturbed CBP expression in human cancer [0.03%]
人类癌症中CBP缺乏和异常表达的流行率及临床意义
Victoria Chirico,Tabea Lenkeit,Seyma Büyücek et al.
Victoria Chirico et al.
CBP (CREB-binding protein) is a ubiquitously expressed major histone modifier involved in the regulation of thousands of genes. In cancer, loss-of-function and overexpression can occur. To clarify the role of CBP expression, a tissue microa...
Zi-Han Chen,Dan Li,Jian-Yu Zhang et al.
Zi-Han Chen et al.
Kidney disease poses a serious threat to human health and life, while the lack of specific therapeutic targets hinders the treatment of kidney disease. Emerging evidence shows that post-translational modifications (PTMs), particularly SUMOy...
Persistent renin-angiotensin system and inflammatory dysregulation following COVID-19 impairs ischemic stroke recovery [0.03%]
新冠病毒后的肾素血管紧张素系统和炎症失调影响缺血性卒中的恢复
Amy May Lin Quek,Ooiean Teng,Ju-Hea Park et al.
Amy May Lin Quek et al.
Previous studies indicate that stroke recovery is worse in patients with prior COVID-19, suggesting persistent biological perturbations. We investigated lingering renin-angiotensin system (RAS) and inflammatory alterations after COVID-19 to...
Prospective evaluation of copy number alterations validates chromosome 1q gain as an independent marker of poor prognosis in localized Ewing sarcoma [0.03%]
前瞻性评估拷贝数变化，确认染色体1q增益为局部Ewing肉瘤不良预后的独立标志
Juan Díaz-Martín,Andreas Ranft,Maite Blanquer-Maceiras et al.
Juan Díaz-Martín et al.
Background: Ewing sarcoma is a rare and aggressive tumor affecting mainly adolescents and young adults. Accurate risk stratification is critical for treatment tailoring, yet traditional clinical parameters lack sufficient...
RBFOX2: An RNA-binding protein with alternative splicing and non-alternative splicing regulatory functions [0.03%]
RNA结合蛋白RBFOX2具有可变剪接和非可变剪接调控功能
Wei Wang,Yang Zhang,Siyi Liu et al.
Wei Wang et al.
RNA-binding Fox-1 homolog 2 (RBFOX2) is a key RNA-binding protein that primarily functions by regulating alternative splicing. Furthermore, RBFOX2 regulates RNA metabolism across the transcriptional and multiple post-transcriptional stages,...
Histopathological analysis reveals mild to moderate changes in BALB/c mice after short-term administration of a microemulsion loaded with epoxy-α-lapachone [0.03%]
短期给药环氧-α-律草酮载药微乳的病理组织学分析结果表明BALB/c小鼠气管内给药后的轻至中度变化
Luiz Filipe Gonçalves-Oliveira,Juliana Figueiredo Peixoto,Bernardo Acácio Santini Pereira et al.
Luiz Filipe Gonçalves-Oliveira et al.
The development of innovative treatments for American Cutaneous Leishmaniasis is crucial due to severe side effects of current treatment and the emergence of non-responder parasites. To address such a challenge the incorporation of epoxy-α...
High KCNJ14 expression is associated with an immunosuppressive tumor microenvironment and advanced pathological features: An RNA in situ hybridization-based analysis of colorectal carcinoma [0.03%]
KCNJ14高表达与免疫抑制性肿瘤微环境及进展期病理特征相关：结直肠癌的RNA原位杂交分析
Hiroshi Sawaguchi,Takeshi Uehara,Mai Iwaya et al.
Hiroshi Sawaguchi et al.
Colorectal carcinoma (CRC) remains one of the leading causes of cancer-related deaths worldwide, and there is a lack of reliable biomarkers to predict tumor progression and the immune microenvironment. KCNJ14 is a member of the inwardly rec...
Breaking barriers: Innovative therapies for managing homozygous familial hypercholesterolemia [0.03%]
突破壁垒：同型家族性高胆固醇血症的创新疗法
Shuai-Jie Huang,Ping Huang,Nan-Nan Song et al.
Shuai-Jie Huang et al.
Homozygous familial hypercholesterolemia (HoFH) is a rare autosomal recessive disorder characterized by variants in genes involved in the regulation of low-density lipoprotein cholesterol (LDL-C) metabolism. The genetic basis of HoFH is com...
Mechanism and importance of ferroptosis in clear cell renal cell carcinoma treatment [0.03%]
铁死亡在透明细胞肾细胞癌治疗中的机制和意义
Manvi Agarwal Neeraj,Songmi Noh,JeeHoon Chae et al.
Manvi Agarwal Neeraj et al.
Metabolic reprogramming is a common phenomenon that is observed in diverse cancer types. Clear cell renal cell carcinoma (ccRCC) is termed a metabolic disease due to its dysregulated lipid and glucose metabolism. Among kidney cancers, ccRCC...