Diminution of miR-340-5p levels is responsible for increased expression of ABCB5 in melanoma cells under oxygen-deprived conditions [0.03%]
缺氧条件下miR-340-5p水平降低通过ABCB5影响黑色素瘤细胞的耐药性机制研究
Michal Wozniak,Malgorzata Sztiller-Sikorska,Malgorzata Czyz
Michal Wozniak
Melanoma is usually highly refractory to chemotherapy. This resistance to treatment is mainly due to high heterogeneity and plasticity of melanoma cells strictly connected to changes in tumor microenvironment. Hypoxia can drastically alter ...
Multinucleated giant cells in atherosclerotic plaques of human carotid arteries: Identification of osteoclast-like cells and their specific proteins in artery wall [0.03%]
人颈动脉粥样硬化斑块中的多核巨细胞：识别动脉壁中破骨细胞样的细胞及其特异性蛋白质
Jian-Hua Qiao,Vivek Mishra,Michael C Fishbein et al.
Jian-Hua Qiao et al.
The mechanism(s) mediating atherosclerotic calcification may be similar to those governing bone remodeling, and osteoblast-like cells have been observed in plaque. We tested the hypothesis that osteoclast-like cells (OLCs) also exist in ath...
Pituitary adenoma-neuronal choristoma is a pituitary adenoma with ganglionic differentiation [0.03%]
垂体腺瘤-神经异位瘤是一种具有神经节分化的垂体腺瘤
Michaela T Nguyen,Ehud Lavi
Michaela T Nguyen
The presence of ganglion cells within an endocrine pituitary tumor has been named hamartoma, choristoma, gangliocytoma, or most recently pituitary adenoma-neuronal choristoma (PANCH). The presence of neuronal differentiation in regular pitu...
Ghanim Aljomah,Susan S Baker,Wensheng Liu et al.
Ghanim Aljomah et al.
Mounting evidence supports a contribution of endogenous alcohol metabolism in the pathogenesis of non-alcoholic steatohepatitis (NASH). However, it is not known whether the expression of alcohol metabolism genes is altered in the livers of ...
Reactive protoplasmic and fibrous astrocytes contain high levels of calpain-cleaved alpha 2 spectrin [0.03%]
反应性原浆型和纤维Ⅱ型星形胶质细胞含高量calpain裂解的αⅡ谱蛋白
Jung H Kim,Soojung J Kwon,Michael C Stankewich et al.
Jung H Kim et al.
Calpain, a family of calcium-dependent neutral proteases, plays important roles in neurophysiology and pathology through the proteolytic modification of cytoskeletal proteins, receptors and kinases. Alpha 2 spectrin (αII spectrin) is a maj...
Dimitry A Chistiakov,Yuri V Bobryshev,Alexander N Orekhov
Dimitry A Chistiakov
Neutrophils are important components of immunity associated with inflammatory responses against a broad spectrum of pathogens. These cells could be rapidly activated by proinflammatory stimuli and migrate to the inflamed and infected sites ...
CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer [0.03%]
CDX2低表达与结肠癌的分化差和MMR缺陷相关
J Olsen,S Eiholm,L T Kirkeby et al.
J Olsen et al.
Background: Homeobox genes are often deregulated in cancer and can have both oncogenic and tumor-suppressing potential. The Caudal-related homeobox transcription factor 2 (CDX2) is an intestine-specific transcription fact...
The influence of DNA degradation in formalin-fixed, paraffin-embedded (FFPE) tissue on locus-specific methylation assessment by MS-HRM [0.03%]
DNA降解对甲基化分析的影响
Iben Daugaard,Tina E Kjeldsen,Henrik Hager et al.
Iben Daugaard et al.
Readily accessible formalin-fixed paraffin embedded (FFPE) tissues are a highly valuable source of genetic material for molecular analyses in both research and in vitro diagnostics but frequently genetic material in those samples is highly ...
Chemopreventive efficacy of hesperidin against chemically induced nephrotoxicity and renal carcinogenesis via amelioration of oxidative stress and modulation of multiple molecular pathways [0.03%]
橙皮素通过改善氧化应激和调节多种分子通路预防化学诱导的肾毒性和肾癌的功效
Aisha Siddiqi,Syed Kazim Hasan,Sana Nafees et al.
Aisha Siddiqi et al.
In the present study, chemopreventive efficacy of hesperidin was evaluated against ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and carcinogenesis in wistar rats. Nephrotoxicity was induced by single intraperitoneal inje...
Susceptibility of monocytes to activation correlates with atherogenic mitochondrial DNA mutations [0.03%]
单核细胞激活的敏感性与动脉粥样硬化线粒体DNA突变相关性研究
A N Orekhov,A V Zhelankin,K I Kolmychkova et al.
A N Orekhov et al.
We have recently evaluated the susceptibility of circulating monocytes to pro- and anti-inflammatory activation comparing samples from healthy individuals and patients with asymptomatic carotid atherosclerosis. Surprisingly, we found a dram...