MiR-205 functions as a tumor suppressor via targeting TGF-α in osteosarcoma [0.03%]
microRNA-205通过靶向转化生长因子-α在骨肉瘤中发挥肿瘤抑制作用
Guojin Yang,Peng Zhang,Aibin Lv et al.
Guojin Yang et al.
Osteosarcoma (OS) is the most common primary bone cancer, and it is most prevalent in children and young adults. The prognosis of OS remains poor, and survival of OS reached a plateau. The discovery of microRNAs (miRNAs) provides a new poss...
Reduced expression of adherens and gap junction proteins can have a fundamental role in the development of heart failure following cardiac hypertrophy in rats [0.03%]
粘附连接蛋白和缝隙连接蛋白表达降低在心肌肥厚进展为心力衰竭中起重要作用
Daniele O dos Santos,Valdecir Blefari,Fernanda P Prado et al.
Daniele O dos Santos et al.
Hypertension causes cardiac hypertrophy, cardiac dysfunction and heart failure (HF). The mechanisms implicated in the transition from compensated to decompensated cardiac hypertrophy are not fully understood. This study was aimed to investi...
RNA sequencing identifies crucial genes in papillary thyroid carcinoma (PTC) progression [0.03%]
RNA测序鉴定出乳头状甲状腺癌(PTC)进展中的关键基因
Jie Qiu,Wenwei Zhang,Qingsheng Xia et al.
Jie Qiu et al.
Purpose: The study aims to uncover molecular mechanisms of PTC (papillary thyroid carcinoma) progression and provide therapeutic biomarkers. Methods: ...
MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma [0.03%]
MicroR-140-5p通过靶向ADAM10介导的诺特定点信号途径抑制下咽鳞状细胞癌肿瘤细胞迁移和侵袭
Peihang Jing,Na Sa,Xianfang Liu et al.
Peihang Jing et al.
MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides that negatively regulate gene expression at the post-transcriptional level. Downexpression of miR-140-5p was reported in some human cancers, and combined with a re...
VZV, temporal arteritis, and clinical practice: False positive immunohistochemical detection due to antibody cross-reactivity [0.03%]
VZV、颞动脉炎和临床实践：由于抗体交叉反应导致的假阳性免疫组化检测
David J Pisapia,Ehud Lavi
David J Pisapia
Varicella Zoster Virus (VZV) antigen has been reported to be present in the majority of temporal artery biopsies with implications for antiviral treatment in patients with giant cell arteritis. Using immunohistochemistry with VZV antibodies...
ALDH(+)/CD44(+) cells in breast cancer are associated with worse prognosis and poor clinical outcome [0.03%]
乳腺癌中的ALDH+/CD44+细胞与较差的预后和临床结果不佳有关
Yan Qiu,Tianjie Pu,Peng Guo et al.
Yan Qiu et al.
Background: Breast cancer stem cells (BCSCs) play essential roles in tumor metastasis and contribute to remarkably negative clinical outcomes. Recently, aldehyde dehydrogenase (ALDH) and CD44 positivity (ALDH(+)/CD44(+)) ...
Over-expression of nuclear NF-κB1 and c-Rel correlates with chemoresistance and prognosis of serous epithelial ovarian cancer [0.03%]
核NF-κB1和c-Rel高表达与浆液性上皮卵巢癌的化疗耐药及预后有关
Ting Shuang,Min Wang,Yingying Zhou et al.
Ting Shuang et al.
Objective: This study aims to measure the expression and subcellular location of NF-κB1 and c-Rel protein in serous epithelial ovarian cancer (EOC), and to test the correlation between NF-κB1 and c-Rel expression and cl...
LASP-1, regulated by miR-203, promotes tumor proliferation and aggressiveness in human non-small cell lung cancer [0.03%]
受miR-203调控的LASP-1促进人类非小细胞肺癌增殖和恶性进展
Jie Zheng,Fangping Wang,Shijun Lu et al.
Jie Zheng et al.
The LIM and SH3 protein 1 (LASP-1) has been reported to be associated with tumor development and progression. However, the expression and potential function of LASP-1 in human non-small cell lung cancer (NSCLC) remains undefined. Thus, this...
Intra-tumor heterogeneity of microRNA-92a, microRNA-375 and microRNA-424 in colorectal cancer [0.03%]
结直肠癌中microRNA-92a、微小核糖核酸-375和微小核糖核酸-424的瘤内异质性研究
Rikke Karlin Jepsen,Guy Wayne Novotny,Louise Laurberg Klarskov et al.
Rikke Karlin Jepsen et al.
Various microRNAs (miRNAs) have been investigated in order to improve diagnostics and risk assessment in colorectal cancer (CRC). To clarify the potential of miRNA profiling in CRC, knowledge of intra-tumor heterogeneity in expression level...
Protective effects of matrine on experimental autoimmune encephalomyelitis via regulation of ProNGF and NGF signaling [0.03%]
小檗碱通过调节ProNGF和NGF信号对实验性自身免疫性脑脊髓炎的保护作用
Lin Zhu,Qing-xia Pan,Xiao-Jian Zhang et al.
Lin Zhu et al.
Inflammation, demyelination, oligodendrocyte (OLG) death, and axonal degeneration are primary characteristics of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). OLGs generate myelin sheaths tha...