Genomic landscapes of endogenous retroviruses unveil intricate genetics of conventional and genetically-engineered laboratory mouse strains [0.03%]
基因组景观下的内源性逆转录病毒揭示了近交系小鼠（包括基因工程小鼠）遗传背景的复杂性
Kang-Hoon Lee,Debora Lim,Sophia Chiu et al.
Kang-Hoon Lee et al.
Laboratory strains of mice, both conventional and genetically engineered, have been introduced as critical components of a broad range of studies investigating normal and disease biology. Currently, the genetic identity of laboratory mice i...
Identification of inflammatory factor TNFα inhibitor from medicinal herbs [0.03%]
从药用植物中鉴定炎症因子TNFα抑制剂
Hong Ye,Yali Wang,A Bennett Jenson et al.
Hong Ye et al.
The inflammatory response is one of the first defenses our body has to fight against potential endangerments. It plays a critical role in host defense, clearing and slowing the infection in the case of microbial invasion. During an inflamma...
MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs) [0.03%]
T细胞缺陷小鼠的MmuPV1感染和肿瘤发育被正常同基因型小鼠免疫MVLPs的高免血清被动转移预防
Joongho Joh,Shin-je Ghim,Paula M Chilton et al.
Joongho Joh et al.
Infection by mouse papillomavirus (PV), MmuPV1, of T cell-deficient, B6.Cg-Foxn1(nu)/J nude mice revealed that four, distinct squamous papilloma phenotypes developed simultaneously after infection of experimental mice. Papillomas appeared o...
Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype [0.03%]
以细胞毒性表型为主的EB病毒相关CD30阳性外周T细胞淋巴瘤伴主要肝受累
Yue Peng,Junchao Cai,Changjun Yue et al.
Yue Peng et al.
Primary hepatic peripheral T-cell lymphoma (PTCL) is exceedingly rare. We encountered such a case in a 58-year-old Hispanic female with a history of chronic sinusitis and hypothyroidism who presented with 4weeks of fever and weight loss. La...
Dimitry A Chistiakov,Alexander N Orekhov,Yuri V Bobryshev
Dimitry A Chistiakov
Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the modern community. Both pathologies are chronic inflammatory disorders, which are influenced by multiple risk factors. In part, these factors such as age, ...
High concentrations of H2O2 trigger hypertrophic cascade and phosphatase and tensin homologue (PTEN) glutathionylation in H9c2 cardiomyocytes [0.03%]
H₂O₂高浓度通过触发心肌细胞肥大级联和磷酯酶及张力同源物谷胱甘肽化来抑制Akt/mTOR通路
Nadia Panera,Daniela Gnani,Emanuela Piermarini et al.
Nadia Panera et al.
Cardiac hypertrophy occurs in response to different stimuli and is mainly characterized by an enlargement of cardiomyocyte size. During hypertrophy, cardiomyocytes undergo not only radical changes of the cellular architecture but also activ...
RP105 protects against myocardial ischemia-reperfusion injury via suppressing TLR4 signaling pathways in rat model [0.03%]
人源性单克隆抗体RP105通过抑制TLR4信号途径保护心肌免受缺血再灌注损伤
Xinxin Li,Jun Yang,Jian Yang et al.
Xinxin Li et al.
Myocardial ischemia-reperfusion (I/R) injury severely impacts the postoperative survival rate of coronary atherosclerotic heart disease. Radioprotective 105 kDa protein (RP105) is a regulator of Toll-like receptor 4 (TLR4), an inflammatory ...
microRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway [0.03%]
MicroRNA-126靶向PIK3R2通过调节PI3K / AKT途径促进类风湿关节炎滑膜成纤维细胞增殖和抗凋亡作用
Jie Gao,Xiao-Li Zhou,Rui-Na Kong et al.
Jie Gao et al.
Objective: The purpose of our study was to elucidate the impact of microRNA-126 (miR-126) targeting PIK3R2 gene on cell proliferation and apoptosis of rheumatoid arthritis synovial fibro-blasts (RASFs) by regulating PI3K/...
CXCR4, CXCR7, and CXCL12 are associated with trophoblastic cells apoptosis and linked to pathophysiology of severe preeclampsia [0.03%]
趋化因子受体CXCR4、CXCR7及其配体CXCL12与胎盘绒毛细胞凋亡及子痫前期病理生理的相关性研究
Jing Lu,Wen-Hui Zhou,Liang Ren et al.
Jing Lu et al.
Preeclampsia is a pregnancy disorder with sudden onset of maternal hypertension and proteinuria, which is characterized by defective cytotrophoblast invasion, increased apoptosis in cytotrophoblast, and diminished syncytial differentiation....
Loss of FAT1 during the progression from DCIS to IDC and predict poor clinical outcome in breast cancer [0.03%]
脂肪瘤蛋白1在导管内原位癌向浸润性导管癌进展过程中丢失并预示乳腺癌预后不良
Li Wang,Shuhua Lyu,Shuling Wang et al.
Li Wang et al.
FAT1 and β-catenin are important tumor regulatory factors. The aim of this study was to detect the possible disparity in their expression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) and to explore its correlatio...