Head and neck squamous cell carcinomas of unknown primary: Can ancillary studies help identify more primary tumor sites? [0.03%]
未知原发灶的头颈部鳞癌：辅助检查能否发现更多的原发肿瘤部位？
Troy Hutchens,Wade Thorstad,Xiaowei Wang et al.
Troy Hutchens et al.
A subset of head and neck squamous cell carcinomas present solely as metastatic disease in the neck and are of unknown primary origin (SCCUP). Most primary tumors will ultimately be identified, usually in the oropharynx. In a minority of ca...
FANCD2 expression affects platinum response and further characteristics of high grade serous ovarian cancer in cells with different genetic backgrounds [0.03%]
FANCD2表达影响不同遗传背景高阶浆液性卵巢癌细胞的铂敏感性及其进一步特征
Sarah J Taylor,Robert L Hollis,Charlie Gourley et al.
Sarah J Taylor et al.
High-grade serous ovarian cancer (HGSOC) is the most prevalent subtype of ovarian cancer and demonstrates 5-year survival of just 40%. One of the major causes of mortality is the development of tumour resistance to platinum-based chemothera...
Epithelial-mesenchymal transition associated markers in sarcomatoid transformation of clear cell renal cell carcinoma [0.03%]
透明细胞肾细胞癌肉瘤样转化的上皮间质转化标志物表达分析
Tanja Čugura,Emanuela Boštjančič,Sara Uhan et al.
Tanja Čugura et al.
Epithelial-mesenchymal transition (EMT) plays a pivotal role in the development and progression of many cancers. Partial EMT (pEMT) could represent a critical step in tumor migration and dissemination. Sarcomatoid renal cell carcinoma (sRCC...
Proteomic analysis of the effects of Dictyophora polysaccharide on arsenic-induced hepatotoxicity in rats [0.03%]
Dictyophora多糖对砷致肝损伤大鼠蛋白组学的影响分析
Xi Yan,Xiaolu Chen,Xinglai Zhang et al.
Xi Yan et al.
Arsenic (As) is a highly toxic environmental toxicant and a known human carcinogen. Long-term exposure to As can cause liver injury. Dictyophora polysaccharide (DIP) is a biologically active natural compound found in the Dictyophora with ex...
Overexpression of TSPAN8 in consensus molecular subtype 3 colorectal cancer [0.03%]
共识分子亚型3结直肠癌中TSPAN8的过表达
Thanawat Suwatthanarak,Pariyada Tanjak,Amphun Chaiboonchoe et al.
Thanawat Suwatthanarak et al.
Background: Recently, consensus molecular subtypes (CMSs) have been proposed as a robust transcriptome-based classification system for colorectal cancer (CRC). Tetraspanins (TSPANs) are transmembrane proteins. They have b...
Aberrant cell adhesiveness due to DNA hypermethylation of KLF11 in papillary urothelial carcinomas [0.03%]
乳头状尿路上皮癌中KLF11基因高甲基化致细胞粘附异常
Koji Tsumura,Mao Fujimoto,Ying Tian et al.
Koji Tsumura et al.
Purpose: The aim of this study was to clarify DNA methylation profiles determining the clinicopathological diversity of urothelial carcinomas. Methods: ...
Congenital heart diseases (CHDs) and forensic investigations: Searching for the cause of death [0.03%]
先天性心脏病和法医调查——寻找死亡原因
Francesco Sessa,Mario Chisari,Monica Salerno et al.
Francesco Sessa et al.
Congenital Heart Diseases (CHDs) are a group of structural abnormalities or defects of the heart that are present at birth. CHDs could be connected to sudden death (SD), defined by the WHO (World Health Organization) as "death occurring wit...
Accurate detection of copy number aberrations in FFPE samples using the mFAST-SeqS approach [0.03%]
使用mFAST-SeqS方法对福尔马林固定石蜡包埋样本中的拷贝数异常进行准确检测
Aude Jary,Yongsoo Kim,Kirsten Rozemeijer et al.
Aude Jary et al.
Background: Shallow whole genome sequencing (Shallow-seq) is used to determine the copy number aberrations (CNA) in tissue samples and circulating tumor DNA. However, costs of NGS and challenges of small biopsies ask for ...
Selenoprotein T, a potential treatment of attention-deficit/hyperactivity disorder and comorbid pain in neonatal 6-OHDA lesioned mice [0.03%]
硒蛋白T可能是治疗新生6-OHDA损伤大鼠注意缺陷多动障碍及其共病疼痛的潜在药物
Wahiba Sif-Eddine,Saadia Ba-M&#x;hamed,Benjamin Lefranc et al.
Wahiba Sif-Eddine et al.
pathological pain and Attention-deficit/hyperactivity disorder (ADHD) are two complex multifactorial syndromes. The comorbidity of ADHD and altered pain perception is well documented in children, adolescents, and adults. According to pathop...
Expression of free fatty acid receptor 2 in normal and neoplastic tissues [0.03%]
游离脂肪酸受体2在正常组织和肿瘤中的表达
Niklas Ruhnke,Anna-Sophia Liselott Beyer,Daniel Kaemmerer et al.
Niklas Ruhnke et al.
Objective: Little information is available concerning protein expression of the free fatty acid receptor 2 (FFAR2), especially in tumours. Therefore, the aim of the present study was to comprehensively characterise the ex...