In Silico analysis unveils rs2109069 of DPP9 as a potential catalyst for COVID-19 severity and risk of inflammatory symptoms [0.03%]
基于计算的分析揭示DPP9基因rs2109069多态性可能是COVID-19重症和炎症症状发病风险的潜在催化剂
Chi-Ying Lee,Zih-Yin Lai,Yung-Jen Chuang
Chi-Ying Lee
Background: During the COVID-19 pandemic, the viral illness caused by SARS-CoV-2 spread through respiratory droplets, resulting in a global pandemic with a range of symptoms from mild to severe. Pathological inflammation ...
Influence of diet and exercise on leukocyte telomere length, markers of oxidative stress and inflammation in rats [0.03%]
饮食和运动对大鼠白细胞端粒长度、氧化应激标志物和炎症的影响
Mehmet Mustafa Tilekli,Ali Kerim Yılmaz,Yavuz Yasul et al.
Mehmet Mustafa Tilekli et al.
Telomere length is an important biomarker of biological aging and is affected by nutrition and physical activity. This study investigated the effects of diets with different fat contents and increased physical activity on certain pro/anti-i...
Pathobiology of myocardial and cardiomyocyte injury in ischemic heart disease: Perspective from seventy years of cell injury research [0.03%]
缺血性心脏病中心肌和心肌细胞损伤的病理生物学：来自70年细胞损伤研究的视角
L Maximilian Buja
L Maximilian Buja
This review presents a perspective on the pathobiology of acute myocardial infarction, a major manifestation of ischemic heart disease, and related mechanisms of ischemic and toxic cardiomyocyte injury, based on advances and insights that h...
Corrigendum to "Irisin and neuroinflammation: Challenges and opportunities" [Experimental and Molecular Pathology 140 (2024) 104941] [0.03%]
关于“irisin与神经炎症：挑战与机遇”的勘误说明[实验与分子病理学140 (2024) 104941]
Erika Yolanda Hernández Sandoval,Zulma Dueñas
Erika Yolanda Hernández Sandoval
Published Erratum
Experimental and molecular pathology. 2024 Dec:140:104943. DOI:10.1016/j.yexmp.2024.104943 2024
Diagnostic criteria and therapeutic implications of rapid-onset demyelinating polyneuropathies [0.03%]
急性脱髓鞘多发性神经病的诊断标准和治疗含义
Wiktoria Rałowska-Gmoch,Magdalena Koszewicz,Beata Łabuz-Roszak et al.
Wiktoria Rałowska-Gmoch et al.
Guillain-Barré syndrome (GBS) and acute-onset chronic inflammatory demyelinating polyneuropathy (A-CIDP) are the most common autoimmune polyneuropathies. Their aetiology is unclear. The pathomechanism includes damage mainly to the myelin s...
Erika Yolanda Hernández Sandoval,Zulma Janeth Dueñas Gómez
Erika Yolanda Hernández Sandoval
Irisin is a myokine that is cleaved from 5-domain type III fibronectin (FNDC5), and is known for its metabolic functions as it stimulates browning of white adipose tissue; similarly, effects on the central nervous system have been described...
Assessing pathogenicity of mismatch repair variants of uncertain significance by molecular tumor analysis [0.03%]
利用分子肿瘤分析评估错配修复变异的意义未知突变致病性
Anne-Sophie van der Werf&#x;t Lam,Noah C Helderman,Arnoud Boot et al.
Anne-Sophie van der Werf&#x;t Lam et al.
Functional analyses are the main method to classify mismatch repair (MMR) gene variants of uncertain significance (VUSs). However, the pathogenicity remains unclear for many variants because of conflicting results between clinical, molecula...
Impaired immunoproteasomal function exacerbates renal ischemia-reperfusion injury [0.03%]
免疫蛋白酶体功能障碍加重肾脏缺血再灌注损伤
Yasushi Ishii,Aya Fukui-Miyazaki,Sari Iwasaki et al.
Yasushi Ishii et al.
Oxidative stress caused by reactive oxygen species (ROS) is involved in the pathogenesis of renal ischemia-reperfusion injury (I/R injury), a major cause of acute kidney injury and delayed graft function (DGF). DGF is an early transplant co...
Histomorphological scoring of murine colitis models: A practical guide for the evaluation of colitis and colitis-associated cancer [0.03%]
小鼠结肠炎模型的组织病理评分：评估结肠炎和结肠炎相关癌的实用指南
Marianne Remke,Tanja Groll,Thomas Metzler et al.
Marianne Remke et al.
Background and aims: Histomorphology is a powerful and cost-efficient tool for evaluating inflammatory and neoplastic conditions. Inflammatory bowel disease (IBD) is a widespread condition with globally rising incidences,...
A weighted and cumulative point system for accurate scoring of intestinal pathology in a piglet model of necrotizing enterocolitis [0.03%]
一个加权和累积的评分系统，可对坏死性小肠结肠炎猪let模型中的肠道病理学进行准确评分
Simone Margaard Offersen,Nicole Lind Henriksen,Anders Brunse
Simone Margaard Offersen
Necrotizing enterocolitis (NEC) is a serious condition in premature infants, in which a portion of the intestine undergoes inflammation and necrosis. The preterm pig develops NEC spontaneously, making it a suitable model for exploring novel...