Research progress of sarcopenia: Diagnostic advancements, molecular mechanisms, and therapeutic strategies [0.03%]
肌少症的研究进展：诊断方法、分子机制及治疗策略
Hao-Lin Wang,Long-Long Liu,Ze-Yu Tan et al.
Hao-Lin Wang et al.
Muscle atrophy or loss is an important sign of human aging. As the aging society approaches and human lifespan prolongs, sarcopenia has emerged as one of the significant risks influencing the quality of life of the elderly. Sarcopenia is a ...
Drug-eluting coronary stents mediate inflammation-associated protein signature in an experimental in vitro study [0.03%]
药物洗脱冠状动脉支架介导的炎症相关蛋白质标志物的实验体外研究
Vera Paar,Xuanchao Feng,Kristen Kopp et al.
Vera Paar et al.
Drug eluting stents (DES) are a first-line treatment for ischemic heart diseases. Due to their direct contact with the blood stream, late stent thromboses are a common complication. Thrombosis and inflammation are tightly linked to each oth...
The interplay involving oxidative stress and autophagy: Mechanisms, implications, and therapeutic opportunities [0.03%]
氧化应激与自噬的相互作用：机制、影响和治疗机会
Noha A Gouda,Assem Zhakupova,Ahmed M Abdelaal et al.
Noha A Gouda et al.
Reactive oxygen species (ROS) are extremely reactive molecules produced during cellular metabolism, which play important roles in signaling and immune responses. Excessive ROS accumulation results in oxidative stress and cellular damage. As...
Twenty-eight-day perfluorooctanoate exposure does not affect immune cell populations in naïve mice [0.03%]
八氟戊酸钠28天暴露未对初始小鼠的免疫细胞群产生影响
Candice Limper,Crystal Silliman,Ethan Cho et al.
Candice Limper et al.
Perfluorooctanoate (C7F15CO2-, PFOA) is a perfluorinated compound widely used in the production of industrial products, such as non-stick cookware and firefighting foams. Although its production has been phased out in the United States, PFO...
NVP-BEZ235 enhances autophagy and ameliorates cognitive deficits by targeting tauopathies [0.03%]
NVP-BEZ235通过靶向tauopathy增强自噬并改善认知缺陷
Ifat Alsharif
Ifat Alsharif
Tauopathies are a class of neurodegenerative disorders characterized by the abnormal accumulation of hyperphosphorylated tau (p-tau) and the formation of neurofibrillary tangles. Autophagy, a fundamental cellular degradation pathway, plays ...
Daidzin suppresses melanogenesis through ERK and AKT signaling pathways mediated MITF proteasomal degradation [0.03%]
Daidzin通过介导MITF的蛋白酶体降解的ERK和AKT信号通路抑制黑色素生成
Jinpeng Lv,Kun Zou,Chuanwei Yin et al.
Jinpeng Lv et al.
Daidzin, a prominent isoflavone found in soybeans, Pueraria lobata, and various legumes, has been extensively investigated for its diverse pharmacological activities, which include anticancer, antioxidant, anti-inflammatory, antiepileptic, ...
Modulating cellular deformability via 3D dextran hydrogel cultivation to regulate the microcirculation of mesenchymal stem cells in murine spleen and liver [0.03%]
通过三维葡聚糖水凝胶培养调控细胞变形性以调节间充质干细胞在小鼠脾和肝中的微循环
Xiaolu Zhu,Zheng Wang,Yuanping Shi et al.
Xiaolu Zhu et al.
For mesenchymal stem cell (MSC) therapy to be effective, the vascular system may be used to deliver and steer the cells to the target tissue. However, the expanded MSCs in petri dishes typically exhibit limited deformability and commonly ex...
Treatment with YKL-05-099, a salt inducible kinase (SIK) inhibitor, attenuates salt-sensitive hypertension: The molecular outcomes of SIK in the kidney [0.03%]
YKL-05-099（一种可诱导盐激酶（SIK）抑制剂）的治疗可以减轻对盐敏感的高血压：SIK在肾脏中的分子作用机制
Dayene S Gomes,Bruna Visniauskas,Prasad V G Katakam et al.
Dayene S Gomes et al.
Salt-inducible kinase (SIK) is a serine/threonine kinase that acts as an intracellular Na+ sensor, playing a role in salt-sensitive hypertension. We aimed to evaluate the therapeutic potential of YKL-05-099, a selective SIK inhibitor, in pr...
Revisiting TAM polarization: beyond M1- and M2-type TAM toward clinical precision in macrophage-targeted therapy [0.03%]
从M1和M2型肿瘤相关巨噬细胞再思考：朝向精准的巨噬细胞靶向治疗
Qingqing Wang,Wenxue Ma
Qingqing Wang
Tumor-associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), significantly influencing cancer progression and therapeutic responses. TAMs polarize into M1 or M2 phenotypes, exerting distinct functional roles. ...
Small intestinal bacteria accelerate aspirin-induced small intestinal injuries [0.03%]
小肠细菌可加速阿司匹林引起的小肠损伤
Fumio Kakizaki,Teruo Miyazaki,Hajime Ueda et al.
Fumio Kakizaki et al.
Background: Small intestinal mucosal injuries are observed during treatment with enteric-coated, low-dose aspirin (LDA) through uncertain mechanism(s). Because aspirin (acetylsalicylic acid, ASA) is an acetylated form of ...