The pathogenesis of chronic eosinophilic esophagitis in SHARPIN-deficient mice [0.03%]
SHARPIN缺陷小鼠慢性嗜酸性粒细胞性食管炎的发病机制
Syu-Jhe Chien,Kathleen A Silva,Victoria E Kennedy et al.
Syu-Jhe Chien et al.
Increased numbers of eosinophils in the esophagus are common in several esophageal and systemic diseases, and a prominent feature of eosinophilic esophagitis. Mouse models can provide insight into the mechanisms of eosinophil infiltration a...
Fut3 role in breast invasive ductal carcinoma: Investigating its gene promoter and protein expression [0.03%]
FUT3在乳腺浸润性导管癌中的作用：研究其基因启动子和蛋白质表达
Jessica Catarine Frutuoso do Nascimento,Steffany de Almeida Ferreira,Juliana Lúcia de Albuquerque Vasconcelos et al.
Jessica Catarine Frutuoso do Nascimento et al.
Fucosylated glycans synthesized by α1,3/4-fucosyltransferase (FUT3) enzyme play an important role in breast cancer prognosis and metastasis, being involved in the binding of circulating tumor cells to the endothelium and being related to t...
CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory response [0.03%]
缺失CD99_like_2（CD99L2）的小鼠在急性炎症反应中存在缺陷
Nakisha S Rutledge,Evan W Weber,Ryan Winger et al.
Nakisha S Rutledge et al.
CD99-Like 2 (CD99L2) is a Type I glycoprotein expressed on leukocytes and endothelial cells as well as other cell types. It is related to CD99, although it shows only 38% sequence identity. CD99L2 has been shown to play a role in leukocyte ...
Hypoxia induced epithelial-mesenchymal transition and vasculogenic mimicry formation by promoting Bcl-2/Twist1 cooperation [0.03%]
低氧通过促进Bcl-2/Twist1合作诱导上皮间质转化和血管生成模仿形成
Kun Liu,Baocun Sun,Xiulan Zhao et al.
Kun Liu et al.
Hypoxia plays a pivotal role in tumor progression. The functions of hypoxia and subsequent Bcl-2/Twist1 activation in epithelial-mesenchymal transition (EMT) and vasculogenic mimicry (VM) formation are currently unclear. This study aimed to...
Hypercholesterolemia aggravates myocardial ischemia reperfusion injury via activating endoplasmic reticulum stress-mediated apoptosis [0.03%]
高胆固醇通过激活内质网应激介导的凋亡加重心肌缺血再灌注损伤
Nan Wu,Xiaowen Zhang,Pengyu Jia et al.
Nan Wu et al.
The effect of hypercholesterolemia on myocardial ischemia reperfusion injury (MIRI) is in controversy and the underlying mechanism is still not well understood. In the present study, we firstly detected the effects of hypercholesterolemia o...
S Sharma,D Kaul,D Singh
S Sharma
Arsenic biology has caught the imagination of scientists across the globe because of its unique association with degenerative diseases in general and cancer in particular. Recent findings have added a new dimension to arsenic biology by rev...
Malignant progression to anaplastic meningioma: Neuropathology, molecular pathology, and experimental models [0.03%]
恶性至间变型脑膜瘤进展：神经病理、分子病理和实验模型
Patrick J Cimino
Patrick J Cimino
Meningioma is a common adult intracranial tumor, and while several cases are considered benign, a subset is malignant with biologically aggressive behavior and is refractory to current treatment strategies of combined surgery and radiothera...
Finding mouse models of human lymphomas and leukemia's using the Jackson laboratory mouse tumor biology database [0.03%]
利用杰克逊实验室小鼠肿瘤生物学数据库寻找人类淋巴瘤和白血病的小鼠模型
Dale A Begley,John P Sundberg,Debra M Krupke et al.
Dale A Begley et al.
Many mouse models have been created to study hematopoietic cancer types. There are over thirty hematopoietic tumor types and subtypes, both human and mouse, with various origins, characteristics and clinical prognoses. Determining the speci...
Troxis necrosis, a novel mechanism for drug-induced hepatitis secondary to immunomodulatory therapy [0.03%]
免疫调节治疗相关药物性肝炎的一种新机制——肠杆菌门毒素所致肝坏死
Christina H Wei,Andrew Penunuri,George Karpouzas et al.
Christina H Wei et al.
Objectives: A case of drug-induced hepatitis mediated by troxis necrosis, a form of autoimmune hepatitis, is described. Methods: Clinic...
Mitochondrial OGG1 protects against PM2.5-induced oxidative DNA damage in BEAS-2B cells [0.03%]
线粒体OGG1通过减轻PM₂·₅诱导的氧化型DNA损伤保护细胞
Lawei Yang,Yahong Wang,Ziying Lin et al.
Lawei Yang et al.
The enzyme 8-oxoguanine glycosylase 1 (OGG1) has been shown to be involved in the repair of oxidative DNA damage. However, the effect of OGG1 on oxidative DNA damage caused by particulate matter 2.5 (PM2.5) is unknown. Herein, we demonstrat...